Delphinapterus leucas (beluga whale): 111166180
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Entry
111166180 CDS
T05885
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
dle
Delphinapterus leucas (beluga whale)
Pathway
dle00310
Lysine degradation
dle01100
Metabolic pathways
dle05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
dle00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
111166180 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
111166180 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
dle03036
]
111166180 (DOT1L)
Enzymes [BR:
dle01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
111166180 (DOT1L)
Chromosome and associated proteins [BR:
dle03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
111166180 (DOT1L)
HMT complexes
Dot1-containing complex
111166180 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
111166180
NCBI-ProteinID:
XP_030620354
UniProt:
A0A7F8KFY2
LinkDB
All DBs
Position
Unknown
AA seq
1730 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKTAMPADTPMDSGAEEEKAGVTTVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTT
NPERKPKKTQSALDLLHAQTVSRAASPSPQGAPYQLPPSTQRRPPEQLLLAPAPPALHRL
LESFKIQYLQFLAYTKTPQYKANLQLLLDQETEKNARLLGAVQQLFGHCQAQKEEIKRLF
QQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNRELRSQSLRLLKARCEEL
KLDWSTLSLEGLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDD
ALSLHLRGKGGLGREPEAEPGRPHLELDCARFSLPHLSNMSPELSMNGHAAGYELCGALS
RPSPKQNTPQYLASPLDQEVVPCTPNHSGRPRLEKLSGLALPDYTRLSPAKLVLRRHLSQ
DHTANSRATASELHSRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPAALQMTGEKGSE
KREQAGPVVCLQGLKERTYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEK
VRSTPSPVPQARESSSTLEKQMGAGTHGSGCSTAGSRSLALAPAGFAYAGSVAISGALAG
SPAPLVSGAEPPALDESSSSGSLFATVGSRSSTPQHPPLLAQPRNCGSASPAPQLCASPR
LGAQGPLPDTSKGDLPSEAGFSDPESEAKRRIVFTISAGSSSAKQSPSSKHSPLSSGARG
DGGQSHGQDSRKRGRRKRAAAGTPGFSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSN
INQPLEITAISSPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSED
EPSSARIERKIATISLESKSPPKTLENGGGLAGRKVPASEPVNSSKWKSTFSPISDLGLA
KAADSPLQAASALSHNSLFAFRPGLEEPGAADAKLAAHPRKSFPGALPGAGGLSPSSHPA
SSFALGGGLAADLSLHSFSDGASLSHKAPEAAGLGTPLSFPGPRGKEGGAADPGPFVNKR
QLDGLAPKGEGGPPVCGPADKASATHGKAGKGRDREPDVKNGHNLFMAAAAAAAAAAAAP
PGGLLSGPGLAPAASSAGGTAPSAQTHRPFLGAFVPGPQFALGPMSLQANLGPSVLQSLF
SSVPAAGLVHVSTAATRLTNSHAMGSFSSGVAGGAVGGAFNHAVPPASAHPFGARFGSGA
ACRSATLSLTPLQAVASTPASSFQAPPPAEPRPPPPPPHLGRPPPGPPALHAPPPPNAAL
PPPPALLPANSEPVLLQNLASLPANQAFLPASSAASVPPANASLSIKLASLPHKVSRPSF
TVHHPPLPGLALAQAAPVIPQASSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq
5193 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggctgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atccggtgggtctgtgaagaaatcccagatctcaagctcgctatggagaattatgtttta
atcgactacgacaccaaaagcttcgaaagcatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacgcagcccatgaagctgaacacg
cggccgtccacggggctcctgcgccacatcctgcagcaggtctacaaccactcggtgacc
gaccccgagaaactcaacaactatgagcccttctccccggaggtgtacggggagacttcc
ttcgacctggtcgctcagatgattgacgagatcaagatgaccgaagacgacctgtttgtg
gacctgggtagcggagtgggccaggttgtgctgcaggtcgctgcggctaccaactgcaaa
catcactatggtgtcgagaaagctgacatcccggccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagaga
ggagatttcctctcagaggagtggagagagcggatcgccaacacgagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggttcgcaaacatg
aaggaaggtggcagaattgtgtcctcgaagccctttgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgcctctaaaa
ggctcggtgtcgtggacggggaagccggtgtcttactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacgaccacccccaccaaggtgccc
gagagcaagacggccatgcccgccgacacccccatggactctggtgctgaggaagagaaa
gccggggtgaccactgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggccggccggaagcgcggacgtcccaagaagatgagcaccacc
aaccccgagcgcaagcccaagaagacccagagcgcactggacctgctgcatgcccagacc
gtgtcgcgggcggcgtcaccctcgccgcagggcgccccctaccagctacctcccagcacg
cagcgacgcccccctgagcagctgctgctggcgcccgccccgcctgccctacaccggctg
ctagaatccttcaagattcagtacctgcagttcctggcgtacacgaagacccctcagtac
aaggccaacctgcagctgctgctggaccaggagacggagaagaacgcccggttgctgggc
gccgtgcagcagctgttcggccactgccaagctcagaaggaggagatcaagaggcttttc
cagcagaaactggacgagctgggagtgaaggcgctgacctacaacgacctgatccaagcg
cagaaggagatctcggctcacaaccagcagctgagggagcagacggagcagctggagaag
ggcaaccgggagctgaggagccagagcctgcggctgctcaaggcacggtgcgaggagctg
aagctggactggtccacgctgtcccttgagggcctgctgaaggagaagcaggccctgaag
agccagatctcggagaagcagaggcactgcctggagctgcagatcagcattgtggagctg
gagaagagccagaggcagcaggagctcctgcagctcaagtcctgcgtgccgcccgacgac
gccctgtccctgcacctgcgcgggaagggtggcctgggccgagagccggaggccgagccc
ggccggccacatctggagctggactgcgccaggttctccctgccccacttgagcaacatg
agcccggagctgtccatgaatggccacgcggccggctatgagctctgcggtgcgctgagc
cggccctcgcccaagcagaacaccccccagtacctggcctcccccctggaccaggaggtc
gtgccctgcaccccgaaccacagtggccggccgaggctcgagaagttgtccggcctggcc
ctgcccgactacaccaggctctccccggccaagctggtgctgcggcgccacctgagccag
gaccacacagccaacagcagggcgaccgccagcgagctgcactcacgagctgagcatgcc
aaggagaacggcctcccgtaccagagccctggcatcgccaacggcatcaaactgagccca
caggaccctcggccctcgtcccctgcggccttgcagatgacgggagagaagggcagtgag
aagcgggagcaggctggcccggtggtgtgtctgcagggtttgaaggagcgcacctacgcc
agcagtggggaggccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcct
agcaagctgccagtcagcatccctctggccagcgtggtgctgcccagccgcgccgagaag
gtgagaagcacccccagccccgtgccgcaggcccgagagtcctcgtccacactggagaag
cagatgggtgctggcacccacggctccgggtgcagcactgctgggagcagaagcctcgcc
ctggcccctgcaggctttgcctacgccggctcagtggccatcagtggggccctggcaggc
agcccggcaccactcgtctctggagccgagccccccgccctggacgagtcctccagctct
ggaagcctctttgccactgtggggtcccgcagctccactcctcagcacccccccctgctg
gcgcagccccgcaactgcggctcggcctcgcccgccccccagctctgcgccagtccccgg
cttggtgcccagggcccgctccccgacaccagcaaaggagacctgccctctgaggccggc
ttctcggatcccgagagtgaagccaagagaaggatcgtcttcaccatctcggccggctct
agcagcgccaagcagtcaccttccagcaagcacagccctctgtcctcgggcgcccgcggt
gacggcggccagagccacgggcaggacagccgcaagaggggcaggaggaagcgggcagcg
gcggggacccccggcttcagctcgggcgtgtcccccaagcgccgggccctgccgtctgtc
gccggcctcttcacccagtcttcagggtcccccctgaacctcaactccatggtcagcaac
atcaaccagcccttggaaatcacggccatctcgtcccccgagagctccctgaagagctcg
cctgtcccttaccaggacaatgaccagccgcccgtgctcaagaaggagaagcccctgagc
cagaccaacggggcccactattccccactgacctcggatgaggagcagggctctgaggac
gagcccagcagtgccagaattgagagaaaaattgcaaccatctccttagaaagcaaatct
cctccgaaaaccttggaaaatgggggcggcctggcgggaaggaaggtgccggccagcgag
ccggtcaacagcagcaagtggaagtccaccttctcgcccatctccgacctcggcctggcc
aaggcagccgacagcccgctgcaggccgcctccgctctgagccacaactccctgttcgct
ttccggcccggcctggaggaacctggcgcggctgatgccaagctggctgcccaccccagg
aagagcttcccaggcgcgctgccgggggcgggcgggctgagccccagcagccatcccgcc
agcagcttcgccctgggcgggggcctggcggccgacctcagtttacacagcttcagcgat
ggtgcttctctctcccacaaggcccccgaggcggccggcctgggcacccccctgagcttt
cccggcccgcggggcaaggagggcggcgccgcagaccccggccccttcgtgaacaagagg
cagctggacggactggccccgaagggcgaggggggcccacctgtgtgcgggcccgcggac
aaggcctcagcgacgcacggcaaggcgggcaagggccgtgaccgcgagcccgatgtcaag
aacggccacaacctcttcatggccgctgctgctgctgccgccgccgccgctgccgccccc
cccgggggcctcctcagcggcccgggccttgccccggcggcatcctcggcagggggcacg
gccccgtccgcccagacccaccgccccttcctgggcgccttcgtccccggcccgcagttc
gcactgggccccatgtccctgcaggccaacctgggcccgtccgtgctgcagtccctgttc
agctccgtgcccgccgccggcctggtgcacgtctcaaccgctgccaccagactgaccaac
tcgcacgccatgggcagcttctcctccggggtggccggcggtgcagtcggaggtgccttt
aaccacgcggtgcctcccgcctccgctcatccgtttggagcccgtttcggcagtggggct
gcatgtcgcagcgccacgctgagcctaaccccgctgcaggcggtggccagcaccccggcc
tcttcctttcaggccccgccccctgcggagccgaggccgcccccgccccctccgcacctg
ggccggccccctccggggccgcccgccctccacgccccgccccctcctaacgccgccttg
cctcctccccccgcgctgctcccggctaactctgagcccgtgctcctgcagaacctcgcg
tccctcccagctaaccaagctttcttacctgcctcctctgctgcctctgtgccgcctgct
aacgcctctctgtccatcaagctcgcctcacttccgcacaaggtgtcccgcccctccttc
acggtgcaccacccgcccctgcccgggctggccctggcccaggccgcgcccgtgatcccg
caggccagctccacggggccgcccgccgtgtgggtttcccttggcatgccacctccgtat
gccgcgcgccttgcgggggttaagccgcgataa
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integrated database retrieval system
