KEGG   PATHWAY: ebt00260
Entry
ebt00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Shimwellia blattae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ebt00260  Glycine, serine and threonine metabolism
ebt00260

Module
ebt_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ebt00260]
ebt_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ebt00260]
ebt_M00621  Glycine cleavage system [PATH:ebt00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Shimwellia blattae [GN:ebt]
Gene
EBL_c19410  lysine-sensitive aspartokinase III [KO:K00928] [EC:2.7.2.4]
EBL_c36840  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
EBL_c33470  thrA; bifunctional aspartokinase/homoserine dehydrogenase I (AKI-HDI) [KO:K12524] [EC:2.7.2.4 1.1.1.3]
EBL_c38530  metL; bifunctional aspartokinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
EBL_c02020  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EBL_c33460  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
EBL_c33450  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
EBL_c25400  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EBL_c10170  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EBL_c24440  ycdW; putative 2-hydroxyacid dehydrogenase YcdW [KO:K12972] [EC:1.1.1.79 1.1.1.81]
EBL_c01250  yiaE; 2-keto-D-gluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EBL_c08380  garK; glycerate kinase 2 [KO:K00865] [EC:2.7.1.165]
EBL_c26430  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
EBL_c33520  gpmB; phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]
EBL_c38890  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
EBL_c06070  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EBL_c25110  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
EBL_c33610  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
EBL_c21590  ydfG; NADP-dependent l-serine/l-allo-threonine dehydrogenase Ydfg [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EBL_c38930  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
EBL_c38920  tdh; threonine 3-dehydrogenase NAD(P)-binding protein [KO:K00060] [EC:1.1.1.103]
EBL_c16540  tynA; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
EBL_c06730  gcvP; glycine cleavage system P protein [KO:K00281] [EC:1.4.4.2]
EBL_c06710  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
EBL_c32390  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
EBL_c06720  gcvH; glycine cleavage system H protein [KO:K02437]
EBL_c09780  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
EBL_c17680  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
EBL_c08260  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
EBL_c38100  ilvA; threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
EBL_c00590  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
EBL_c11320  ygeA; aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
EBL_c16070  trpA; tryptophan synthase [KO:K01695] [EC:4.2.1.20]
EBL_c16080  trpB; tryptophan synthase [KO:K01696] [EC:4.2.1.20]
EBL_c19420  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
EBL_c31390  putative ectoine synthase [KO:K06720] [EC:4.2.1.108]
EBL_c19430  L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ebt00010  Glycolysis / Gluconeogenesis
ebt00020  Citrate cycle (TCA cycle)
ebt00230  Purine metabolism
ebt00250  Alanine, aspartate and glutamate metabolism
ebt00270  Cysteine and methionine metabolism
ebt00290  Valine, leucine and isoleucine biosynthesis
ebt00300  Lysine biosynthesis
ebt00330  Arginine and proline metabolism
ebt00460  Cyanoamino acid metabolism
ebt00470  D-Amino acid metabolism
ebt00564  Glycerophospholipid metabolism
ebt00600  Sphingolipid metabolism
ebt00620  Pyruvate metabolism
ebt00630  Glyoxylate and dicarboxylate metabolism
ebt00640  Propanoate metabolism
ebt00680  Methane metabolism
ebt00860  Porphyrin metabolism
ebt00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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