Equus caballus (horse): 100062842 Help Entry 100062842         CDS       T01058                                  Symbol SYNE1 Name (RefSeq) nesprin-1   KO K19326   nesprin-1 Organism ecb  Equus caballus (horse) Pathway ecb04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:ecb00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     100062842 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:ecb03036]     100062842 (SYNE1) Chromosome and associated proteins [BR:ecb03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     100062842 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin CH KASH Collagen_mid STIV_B116-like Motif Other DBs NCBI-GeneID:  100062842 NCBI-ProteinID:  NP_001296133 Ensembl:  ENSECAG00000017353 VGNC:  23801 LinkDB All DBs Position 31:14655174..15097220 Genome browser AA seq 8798 aa AA seqDB search MASARTASRSPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS IVLGLMWTIILYFQIEELTSNLPQLQSLSSSTSSVDGVVSSETASPPSKRKVATKIQGNA KKALLNWVQYIAAKQTGIEVKDFGRSWRSGVAFHSVIHAIRPELVDLEKLKGRSNRENLD EAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKQYPDIHNTGTDGQETDEIIP GFPSFANSIQNFKRDDRLILKETKVWIEQFERDLTRAQMTESNLQDKYQSFKHFRVQYEI KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVSSRLFDWHIQLDKSLPAPLGTIGAWLYR AELALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVELLL QNYISFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE VRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHWIQQHTAM NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADELDRMKKEYADCITTL SDFAAEAHRKLSEPLEVSFINVKLLIQDLEDIEQRVPVMDAQYKMITKTAHLITKESSQE EAKEMFATMSGLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTFFYESLGKINEILTV LEHEAQSSALFKQKHQELLACQESCKKTMTQIEKGSQNVQKFVTLSKVLKHFDQKKLQRQ IADAHVAFQNMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRTAQEGMEEKGNPEDLL RRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL HLKIDVEKNRFLASVEECRTELDRETKLVPQEGSEKILKEHRIFFSDKGPHHLCEKRLQL IEELCLKLPVRDPVRNTPETCHVTLKELRAAIDSTYAKLVEDPDKWKDYTGRISEFSSWI SAKETQLKEIKSEAIDTANHGDIKHAVEEIRNDVSKKGEILNWLKSRLKILIEVSSENEA QKQGDELAKLSSSFKAFVTLLSEVEKRVSNFGDCVQYKEIVQSSLEELISGSKEVQEQAE KILDAESLFEAQQLLLHHQQKTKRISAKKQDVQQQLAQARQGEGGLPSQAQEELWKLEST LDSMEHSREKQERRIQLTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE QTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSVREQVKKLEGTLEEDIKT MEMVKNKWDHFGNNFETLSVWITEKEKELSALETSSSAMDMQISQIKVIIQEIESKISSI TGLEEAAQSFAQFITTGESARIKAKLTQIRRYWEELREHAQCLEGTILGHLSQQQKFEEN LRKIQQSVSEFENKLAEPIKICSSATETYKVLQEHMDLCQALESLASTVAAFSASARKVA NRGSSVQEAAALQQRYEGMLNQAKERQTVLENVLAHWQRLEKELSTFLTWLERCEAIASS PEMDISADRVKVESELQLTQALQNEVVSQASIYSNLLQLKESLFSVASKDDVKMMKLHLQ QLDERWRDLPQIISKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSKLQTTSEISLTDHQ AALTRHKDHAAEVESKKGELQSLQSHLVRLGALGRGEDLHLLQGKAEDCFQLFEEASQVV ERRQLALAQLAEFLQSHASLSAVLHRLRETVEATHSMNKKQSDLLEKDLKNAIQDVKTLE STAISLDGVLTKAQYHLKSGSSEQRTSCRTTADHLCFELERIQNLLGTKQSEADALAVLK KAFQDQKEELLKSIEDIEERTDKERLKELTRQALQQRLRVFNQLEDELNSHEHELCWLKD KAKQIAQKDVGFAPEVDREINCLEVTWNDTKKLIHENQGQCCGLIDLMREYQNLKSAVSK VLEKASNVIATRTTIKDQEDLKWALSKHETAKNEMCNKQKELDNFTSKGKQLLSELKKIH SSDFTLVKRDMENTVDKWLDVSERIEENMDKLRLSLSIWNDVLSGKEEIDGWSNNSVPQL AESISNLNNSLKAEEFLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPELQFIEAD LRQKLEHAKEITEEAKGTLKEFAAQSTQVEKFINDITTWLTKLEESLMNFAQTETCEGLK KVKEIQKELQSQQSNISSTQENLNSLCRKYHSVELESLGSAMTGLIKKHEAASQLCSKTQ ASLQDSLEKHFNESMREFQEWFSGTKEAAKKSSDRTGDSKVLEAKLHDLQNILDSVSDGQ SKLDAVTQEGQTLYAHVSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCALELGSF EDQHRKLNLWIREMDERLSTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQR GQVLSEEGHGAGKEGRLCSQLLSNYQNLLRMTKEKLRSCQVALQEHEALEEALRSMWSWV KDVQDRLACAESTPGSKDTLEKRLLQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ KVIQTQLQTLKDVWADIMSSSVRAQSTLEAVISQWNDYLEWKNQLEQWMESVDQKVEHPL KAQPGLKEKFALLDHFQSIVSEGEEHAQVLHRLITKSRELCQKTEDESFKEAAQEELKTQ FNDIMTVAKEKMRKVEEIVKDHLMYLDAIQEFTDWLHSAKEELHRWSDMSGDSLATQKKL SKIKELMDSREIGASRLSRVESLAPAVKQNTTASGCELMDTEMQALCADWKQWEDSVFQT QTSLENLVSQMALSEQEFSGQVAQLEQGLEEFSALLTSWAQQLTLLEGKNTDKEIVECWQ KGQEILDALQKAEPKTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN KEQILQQRFRRAFKDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQELLSESENGQHK LNTMLSKGELLSTLLTKEKANGIQAKIATAKEDWKNFHSNLHQKESALENLKIQMKDFEV SAEPVQDWLSKTEKVVHESSNRLYDLPAKRREQQKLQSVLEEINCYEPQLNRLKEKAQQL WEGQAASKSFMHRVSQLSSQYLALSNLTKEKVSRLDRTVAEHNQFSLGIKELQDWMTDAV HMLDSYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGVAAIQ QQLQSVKDMWAALLSAGIRCKSQLEGALSKWTSYQDDVRQFSSWMDGVEASLNESERQYA ELREKTTALGKAKLLNEEVLSHSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIKERA KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDRYSVLEGDAHTHESTLRDLQELQV HCAEGQALLNSVLHTREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTQFNNVVNKL RLMEQKFQQVDEWLKTLEEKVSLRPGRQSNRATKETQLHQMKKWHEEVTTYRDEVEEVGA RAQEILDESHVSSQLGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESELSLSSYSDW YSSTHKNFKNVAAKIDKVDQAMMGKKMRTLEGLLKDMEKGHSLLKSAREKGERALRYLED DEAETLRKEIHHHVEQLKELTSTVRKEHMTLEKGLHLAKEFSDKYKALTQWIAEYQEILQ IPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVALKEKIDKLQ DDYQDLCSAGKEHVCSLEAKVRDHEGYNSELQEVEKWLLQMSGRLVAPDLMETSSLETIT QQLAHHKAMMEEIASFEERLNNLKIKGDDLISQCADHLQAKLKQNVHTHLQGTRDSYSAI CSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLKPSPHPPLSRAEAVKQVKHFR ALQEQARTYLDLLCSMCDLSNSSVKTTAKDIQQTEQMIEQRLAQAQNLTQGWEEIKHMKA EFWIYLQDADQQLQNMKRRHAELELNIAQNMVSQVKDFVKKLQGKQASVTAITDKVNKLT KKQESPEHKEISHLNDHCLDLCLQSNNLCLQREEDLQRTRDYHDCMNVVEAFLEKFTTEW DNLARSDAESTAVHLEALKKLALALQERKQAVDNLKDQKQKMIEHLNLDDKELVKEQTSH LEQRWFQLEDLVKRKIQVSVTNLEELNVVRSRFQELMEWAEEQQPNIAEALKQSPPPEMA QNLLMDHLAICSELEAKQMLLKSLMKDADRVMADLGLNERQIIQKALSDAQRHVNCLSDL VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFRDHICLLPDDVSKQVKTCKSAQ ASLKTYQNEITGLWAQGRELMKGATEQEKGEVLGKLQELQSVYDTVLQKCSHRLQELEKN LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESTELQTQLAKYQHILEQSPEYENLLL MLQRTGQAILPSLNEVDHSYLSEKLSALPLQFNVIVALAKDKFYKIQEAILARKEYASLI ELTTQSLSELEDQFLKMSHVPTDLVVEEALSLQEGCRALLGEVAGHGEAVGELNQKKESF RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHTKMSHQLEKQLDNVKTE QSKVNEETLPAEEKLKIYHSLAGSLQDSGILLKRVTVHLEDLVPHLDPLAYEKAKHQIQS WQDELKLLTSAIGATVTECENRMVQSIDFQTEMSRSLDWLRSVKAELSGPLCLDLNLRDI QEEIRKIQIHQEEVQSSLRIMNALSNKEKEKSTKAKELLSADLQHTLADLSELDGDIQEA LRTRQAALTQIYSQCQRYYQVFQAANDWLEDAHEMLQLAGNGLDVESAEENVKSHMEFFS TEDQFHHNLEELQGLVASLDPLIKPTGREDLAQKMASLEERSQRIIQDAHAQLDLLQRCA AQWQDYQKAREEVIELMNDAEKKLSEFSLLKTFSIHEAEEKLSEHKGLASVVNSFHEKIV TLEDKASQLEKTGNDASKATISRSMTTVWQRWSRLRAVAQDQEKILEDAVAEWKSFNNKV KKATEMIDQLQDKLPGSSAEKASKAELLTLLECHDTFVAELEQQQSALGMLRQQALSMLQ DGATPSPGEEPPIVQEIMAMQDRCLNMQEKVKNNGKVVKQELREREVVETQINSVKSWVQ ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKTAEEQKNKYLGLYTILPSELSLQL AEVALDLGTIHDQIQDKVKEVEQDKATSQEFSRQIQKIAKDLTTILTQLRAKTDNLVQAT TEQKVLGEELNGYNVKLMELDEAVQKFSEHNGQLGKPLAKKIGKLSELHQQTIKQAESRL SQLSQAASHLEEYNETLELILKWIDKAKILVHGKIAWNSANQLREQYISHQTMLEESEEI HNDLEAMTEKLQCLASVYYTEKMSQQVAELGRETEELRQVIKIRLQNLHDAAKDMRKFET ELKNLQFALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQICQSALRIP EDVVTNLPLCHAALHLQEEASRLQHTAIQQYNIMQEAAVQYEQYEQEMQHLQELIEGAHR EIEDQPVATSNIQELQAQISRHEELAQKIKGYQEQISSLNSKCKMLTMKAKHATMLLTVT EVDGLAEGTEDLEGELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC RSPSPVANTDASVNQDIAYYQALSAERLQTDAARIHPSTLPSQEFYEAGLEPSATAKLDD LQRSWETLKNVISEKQRTLYEALERQQRYQDSLQSISTKMEAIEMKLSESLEPGRSPESQ MAEHQALMDEILMLQEEITELQSSLAEELVSASPECDPAEQLALQSTLTVLAERMSTIKM KASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDHWLLSTKATLDIALGTPKEPMDM EAQLVDCQNMLVEIEQKVVALSELSVHNENLMLEGKAHTKDEAEQLAVKLRTLKGSLLEL QRALHDKQLNIQGTAQEKEEGDADLTAAQSPSVQEWLAQARTAWTHQRQSSLQQQKELEQ ELAEQKTLLRSVASRGEEILTQHSAAETSGGVGEKPDVLSQDLGMEGEKSPAEDQMRMKW ESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGMPLYKGDGETQDKSAVTSLLDGLN QAFEEVSSQGGGTKRQSIHLEQKLYDGVSATSTWLDDVEERLFVTTALLPEETETCLFNQ ETLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQM KERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKELDAG IIELKRRGDKLQIEQPSMQELSKLQDMYDELMMTIGSRRTGLNQNLALKSQYERALQDLA DLLETGREKMAGNQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVHQE TQFHADLMAQASAVLKRAHKRGVELEYILETWSHLDEDHQELSRQLEAVENSIPSVGLVE ESEDRLIDRTTLYQHLKSSLNEYQPKLYQVLDDGKRLLISVSCSDLESQLNQLGEHWLHN TNKVSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHL NAFLEFSKEVDAKSSLKSSVLSTGNQLLRLKKVDTAALRSELSHIDGQWTDLLTNIPAVQ EKLHQLQMDKLPSRHAISEVMTWISLMENVIQKDEENIKNSIGYKAIHEYLQKYKGFKID INCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEG LLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQTSVQNALKDCQDLEDLIKAKEKEVE KIEQNGLALIQNKKEEVSDVVRSTLRELSQTWADLDHMVGQLKMLLKSVLDQWSHHKVAF DEINSYLMEARYSLARFRLLTGSLEAVQVQVDSLQNLQDDLEKQEKSLQKFGSVTNQLLK DCHPPVTETLSNTLKEANMRWNNLLEEIAEQLHSSKALLQLWQRYKDYSKQCGSMVQQKE DRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFVLHELGEQLKQQVDASAA SAIQSDQLSLSQQLCALEQALCKQQTVLQAGVLDYETFTKSLEALEAWVVEAEDILQGQD PGHSSDLSTIQERMEELKEQMLKFSSMVPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSL ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG SYILTVEAGKQLLLSADSGAEAALQAELTEIQEKWKSASLCLEEQRKKLAFLLQDWEKCE NGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLAQLTLLRDTLC ACISADDISILNERMELLQRQWEELCHQLSLRRQQVSERLNEWAVFSEKNKELCEWLTQM ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQESKIQLQQMGERLARASHESKASEIEYKL GKINDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIAYDSCDS GEIQKKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKTSERTAAFPSSSGVLYTVAKEEL KKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSI LRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLN HSKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDE HDLSDRELELDDSAALSDIHWHDTSADRVLSPPPSSNPSLSLAQPLRSERSGRDTPASVD SIPLEWDHDYDLSRDLESAVSRTLPSEDEEGQEDKDFYLGGAVGLSADPSALESQIRQLD KALDDSRFQMQQTENIIRSKTPTGPELDSSYKGYMKLLGECSGSIDSVRRLERKLREEEE NFPGFVNLNNTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLSNIWTWLGEM EEELEQLQRLGLSTDIQSIELQIKKLKELQKAVDQRKAIILSINLCSSEFTQTGSEESRD LQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQDFHEMSHGLLLMLENIDRRKNEIVPI DSNLDAEILQDHHKQLTQIRRELLESQLKVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG NRLKLLLKEVSRHIKELEKLLDMSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQRTP RGKCSLSQPGPSVNSPHSRSIKGGSDSSLSEPPPARSGRAFLLRVLRAALPLQLLLLLLI GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL NT seq 26397 nt NT seq  +upstreamnt  +downstreamnt atggcatccgccaggacggcttcacggtctcctcgggacattgccaatgtgatgcaaagg ctgcaagatgagcaagagatagtacaaaaacggactttcacaaaatggatcaactctcac ctggccaagcggaaacccccaatggtggtagatgatctttttgaagacatgaaagatggt gttaagctgcttgctcttctggaagtcctgtcggggcagaaactgccttgcgaacaagga cgccgaatgaagcggatccatgctgtggctaacattggcacggcgctcaagttccttgaa ggaaggaagattaaattagtcaacattaactccactgatatagctgatggccgaccctca atagttctcggattgatgtggaccataattctatatttccagattgaggagttgaccagc aacctgccgcagctccagtccttgtccagcagtacatcctctgtagacggcgtggtcagc tctgagactgccagccccccaagtaaacggaaggtggccaccaagatccaaggaaatgct aagaaggctttattaaactgggttcagtacatagcagccaagcagactggaatcgaagtc aaagactttgggcgcagttggagaagtggggttgcctttcattcagtcattcatgccatt cgaccagaattagtggatttggagaaactgaaagggagatctaaccgagaaaatctggac gaggctttcacaattgctgaaacagaactggggatcccaagactactggatcctgaagat gtcgatgtggataaaccagatgagaaatctattatgacctatgtagcccagtttctgaaa caatatccggacatccacaatacaggcaccgacgggcaagagactgatgaaataattcca ggtttcccatcttttgcaaattctatccaaaattttaagagagatgacaggctaattttg aaggaaacaaaagtttggatagaacaatttgaaagagatttgacaagggcacagatgaca gaatcaaatttgcaggataaatatcagtcatttaagcacttcagagttcaatatgaaata aaaaggaaacagattgaacatttaatacaaccattacatagagatggtaaattgtcactt gaccaagcgttggtaaaacagtcctgggacagagtgtcctccaggctctttgattggcat attcagcttgataaatctcttcctgcacctctgggtaccataggagcctggttatacaga gcagagctggctctgagagaggagataaccattcagcaggtccatgaggaaacggccaac acaatacaacgcaaacgtgagcaacacaaggatctgcttcaaaacacagatgcccacaaa agagcgttccatgaaatctaccggaccaggtctgtgaatgggatcccagtgccacctgat caattagaggacatggccgagaggtttcattttgtttcctccacatcagagctacactta atgaaaatggaatttctagagttaaagtaccgtctactctcactgctggttcttgcagag tcaaagctgaaatcttggatcatcaagtatgggaggagagagtcagtggagctgcttctg caaaactacatctcttttatagaaaatagcaagttctttgagcaatatgaagtgacatac cagatcttgaagcagacagctgagatgtacgtcaaagctgatggttcagtggaagaagcc gagaatgtgatgaaattcatgaatgaaactactgcccagtggaggaacctctcagtagaa gttaggagcgtgaggagcatgctggaagaagtcatcgctaactgggatcgatatggcaat actgtggctagtcttcaggcctggctggaggatgctgaaaaaatgctaaatcaatcagaa catgccaaaaaggatttttttcgaaacttgccccattggattcagcagcacactgccatg aatgatgccggcaattttctcattgaaacatgtgatgagatggtttcccgtgatcttaaa caacagttgctgttgctaaatgggcgatggagggagttgtttatggaagttaagcaatat gctcgagctgatgagttggacagaatgaagaaagaatacgcagactgtattactaccctg tctgattttgcagctgaagcccataggaaactttcggagcccttagaagtctctttcatt aatgtcaagttattaattcaagacttggaggatattgagcagagggtgcctgtgatggat gctcagtacaagatgattacaaagacagcacacctcattaccaaagagagctcccaagaa gaagctaaggaaatgtttgcaaccatgtctgggcttaaagaacagctaaccaaggtcaaa gaatgttactccccactcctttatgagtctcagcagctgttgataccgttggaagaatta gaaaaacagatgacattcttttatgaatcacttgggaaaataaatgaaattctaacagtt cttgagcatgaggcacaatcaagtgctctttttaaacaaaaacatcaggaactgttagct tgtcaagaaagctgtaagaaaactatgacacagattgagaaaggcagtcaaaatgttcaa aagtttgtgaccttgagcaaggtgttaaagcattttgatcagaagaagctacagagacag attgcagatgctcatgttgcttttcaaaatatggtaaagaaaactggagattggaagaaa cacgtggaaaccaacagccgcttgatgaagaaatttgaggagtctcgagcagagctggag aaggtgctgcggacggctcaggagggcatggaggaaaaggggaatccagaagacctcctg aggagacatactgagtttttcagtcagctggatcagagggtgctcaatgcttttctgaaa gcttgtgacgagctcaccgacattctccctgagcaggaacagcagggcctgcaggaagct gtcagaaagctgcataaacagtggaaggatcttcaaggagaagccccatatcatttgctt catctgaagattgatgtggagaagaataggttcttagcttcagtggaagagtgcagaacc gagctggatcgagagaccaagctggtgccccaggaaggcagcgaaaagatccttaaagag cacaggattttcttcagtgacaaaggtcctcatcacctctgtgagaaaaggttacagctc attgaagaactgtgtctgaagctcccagtccgggaccctgtaaggaacacccctgagact tgccacgtgacactcaaagagctcagagctgccattgacagcacctatgcgaagctcgtg gaggacccggacaagtggaaggactacactggcagaatttctgagttctcatcttggata tctgcaaaggagacacagttgaaggagattaagagtgaggccatcgatactgccaaccat ggagacattaaacatgctgtagaagagatcagaaatgacgtttccaaaaaaggcgagatt ctcaactggctgaaatccaggcttaaaattttgattgaagtttcttctgagaacgaagcc cagaagcaaggagatgagctggcaaaattgtctagttccttcaaggcttttgtaactttg ttgtcagaggttgaaaagagggtaagcaactttggggactgtgtccagtacaaagaaata gtccaaagttcccttgaagagttaatttctggctctaaagaagtccaggaacaagccgag aagatcttggacgctgaaagtctgttcgaagcgcagcagttgctccttcatcaccagcaa aagacaaagaggatctctgcaaagaagcaggatgtgcagcagcagctcgcacaggctcgg cagggggaaggtgggttgcccagccaggcccaagaagagctgtggaagctggagagcacc ctggacagcatggagcacagcagggagaagcaggaacgccgcatccagctcacgttaaga aaatgggagagatttgaaacaaacaaagagacagtggtcagatacctttttcaaacaggt tccagccacgagcgcttcttgagtttcagcagtttggaaagcttgtcgtcagaactggaa cagacaaaggagttctctaaacgaactgaaggcattgcagtccaggctgagaatcttgtg aaggaagcttcagagataccacttgggcccaagaataagcagctgcttcaacagcaggcc aaatcagtcagagagcaagtcaaaaaattagaaggcacgcttgaagaagatattaaaacc atggaaatggtgaaaaacaagtgggatcattttggcaataattttgagaccctgtccgtc tggattactgagaaagaaaaagaactcagtgctctggaaacttcgtcatctgccatggac atgcaaatcagccaaattaaggtcataattcaagaaatagaaagtaagatcagcagcatt acaggactagaagaagcagctcagtcttttgcccaatttattaccactggagaatctgct 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gaacaagagcaagtgctctacagcaggccaaatcggctcctgtctggcatgccactctac aaaggggacggggagacccaagataaatctgcagtgacctctttgctggatggattgaac caggccttcgaggaggtttcgtcccagggtggagggacgaagaggcagagtattcacttg gaacagaagttatacgatggggtctcagccacctctacttggttggatgatgtcgaagaa cgtttatttgtcaccacagcccttttaccagaagaaacagaaacttgcctcttcaaccaa gagactcttgccaaagatattaaggaaatgtctgaagaaatggataagaacaagaacttg ttttcccaagcatttccagagaatggcgacaaccgagatgttattgaagacactttgggt tgtcttttgggcaggctatccttgctcgactcagtagtcaatcaacgatgtcatcagatg aaggaaagacttcagcaaatactcaatttccagaatgatctgaaggtgctgtttacctca ctggcggacaacaagtacatcattctgcagaagctggcaaatgtgtttgaacagcctgtg gcagagcaaatagaggcaatacaacaggctgaagatgggctcaaggaattggacgcagga atcattgagttaaagaggcgtggtgacaagttgcagattgagcaaccttccatgcaagag ctttccaaactccaggacatgtatgatgaactgatgatgaccattggctcccggcggact ggtctgaaccagaatcttgcactcaagagtcagtatgaacgagccctgcaagatctggcc gacctgctagaaaccgggcgagagaagatggcaggcaatcagaagattatcgtgtcttcc aaagaagaaatccaacaactacttgacaaacacaaggaatactttcagggcctggagtct catatgatcttgactgagacgctcttcagaaagataatcagctttgcagtccaccaggag actcagttccatgcagacctgatggcgcaggcttcagccgtgctgaaacgggctcacaag agaggtgtagagttggagtacattctagagacatggtcccatctggatgaggaccaccag gagctcagcagacagctggaggcagtggaaaacagcatcccgagcgtgggtttagtggag gagagcgaggacaggctcatcgaccggacaacactctaccagcatttgaaatccagcctt aatgaataccagcccaaattatatcaggtattagatgatgggaaacgacttctgatatcc gttagctgctcggatctagaaagccagctaaatcaacttggagaacactggctacataat accaacaaagtgtctaaggagcttcacagattggaaacgatattgaaacactggaccaga tatcaaagcgaatctgcagatctaattcactggctacaatctgcaaaagacaggctagaa ttttggactcaacaatctgtgacagtcccacaagaactggaaatggtccgcgatcatctg aatgctttcctggagttttccaaagaagtggatgccaaatcttccctgaaatcgtctgtt ctgagcactggaaaccagcttcttcgattaaagaaagtggacacagctgccctgcgttct gagctgtcacacattgatggccagtggactgacctgctgacgaacatcccagctgtccag gaaaagctccaccagctccagatggataagctgccttctcgccatgccatttctgaggtc atgacctggatttctctcatggaaaatgttattcaaaaggatgaagagaatataaaaaat tccataggttacaaggcaattcatgaataccttcagaaatataagggtttcaagatagac attaactgtaagcagctgaccgtcgatttcgtgaatcagtctgtgctgcaaatcagcagt caggatgttgaaagcaaacgcagcgataagaccgattttgctgagcaacttggagcaatg aataaaagttggcaaatcctgcagggtctggtaacagagaagatccagctgttggaaggc ttgttagaatcttggtcagaatatgaaaataatgtacagtgtctgaaaacgtggtttgaa acccaggaaaagagactgaagcaacaacatcgaattggagatcagacttcagttcagaat gcattgaaagactgtcaggatctggaagacttgattaaagcaaaagaaaaagaggtagag aaaattgaacagaatggacttgcgttgattcagaacaagaaagaagaagtgtctgacgtt gtcaggagcacgctccgggagctcagccagacctgggcagatttagaccacatggttggg cagttgaagatgctgttgaagtcggtgctggaccaatggagccatcacaaagtggccttt gatgagataaacagttacctgatggaggcgcgatattctctcgcccggttccgtctgctg accggctctctggaagctgtgcaggttcaggtagacagccttcagaatcttcaagatgat ctggaaaaacaggaaaagagcttacagaaatttggctctgtcaccaaccaattattaaaa gattgtcacccacctgtgacagaaactcttagcaatacactgaaagaagccaatatgaga tggaataacttgctggaagagattgctgagcagctgcactccagcaaggccctacttcaa ctctggcaaaggtacaaggactactccaaacagtgtgggtctatggttcagcagaaggaa gatcgaaccaatgagctcttgaaggcagccactaacaaggacatcgctgatgacgaagtt gctacatggattcaagattgcaacgacctcctcaaaggactggggacagtcaaggattcc ctttttgtgctgcatgagctgggagagcaactcaagcaacaagtggatgcttcggcagca tcagccattcaatctgatcagctctctctgagtcaacagttgtgtgccctagagcaggct ctttgcaaacagcagactgtgttacaggctggagttcttgactatgaaactttcaccaag agtttagaagctttggaggcctgggtagtagaagctgaagacatcctgcaagggcaggac cctggccactcatctgacctctcgaccatccaggaaaggatggaagaacttaaggaacag atgttaaaattcagcagcatggtcccagacttagaccgtctaaatgagcttggctacagg ttacccctgaatgacaaggaaatcaaaaggatgcagaatctgaaccggcactggtctctg atctcctctcagacaacagaaagattcagtaagttgcagtcatttttgcttcaacatcag actttcttggaaaaatgtgaaacatggatggaattcctggtccaaacggaacaaaagtta gcagtagagatctcgggcaattatcagcatcttttggagcagcagagagcacatgagttg tttcaagcagagatgttcagtcgtcagcagattttgcactcgatcattattgatgggcaa cgtcttctagagcaaggtcaagttgatgacagggatgagttcaacctgaaattgacactt ctcagtaatcagtggcagggagtgattcgcagggcccagcagaggaggggcatcattgac agccagatacgccagtggcaacgctacagggagatggcagaaaagcttcgtaagtggttg gttgaagtgtcctatctacccatgagtggtctcgggagtgttccaataccactgcaacaa gcaaggaccctctttgatgaagtgcagttcaaagaaaaagtgttcctgcgacagcaaggc agctacatcctaaccgtggaggctggcaaacagctcctgctctcggctgacagtggggct gaggctgccttgcaggccgaactcactgaaatccaggagaagtggaagtcagccagcctg tgtttggaggaacagaggaaaaaactggcatttttgttgcaagattgggaaaaatgtgag aatggaatagctgattctctggagaaactacgaactttcaaaaagaagctttctcagtct ctaccggatcaccacgaagagctccatgcagaacaaatgcgttgcaaggagttggaaaat gcagtggggagctggacagatgacttggcacagttgacactgctgagggacaccctctgt gcctgcatcagtgctgatgatatctccatcctgaacgaacgcatggagcttctgcaaagg cagtgggaagaactatgccaccagctctccttaaggcggcagcaagtaagtgagaggttg aacgaatgggcagtcttcagcgaaaagaacaaggagctttgcgaatggctgactcaaatg gaaagcaaagtttctcaaaatggagacattctcattgaagaaatgatagagaagctcaag aaggattatcaagaggaaattgctattgcccaagagagcaaaatacagctccagcaaatg ggagaacgccttgctagagccagccatgaaagcaaagcgtcggagattgaatacaagctt ggaaagatcaacgaccggtggcagcatctcctggatctcatggcagccagggtaaagaag ctgaaggagactctggtcgctgtgcagcagctggataagaacatgagcagcctgaggacg tggctggctcacatcgagtcagagctggccaagccgatagcctatgattcctgcgactcg ggagaaatacagaagaagcttaacgaacagcaggagcttcagagagacatagagaaacac agcacgggcgtggcctctgtcctcaacctgtgtgaggtcctgctgcatgactgtgatgcc tgtgccacagatgccgagtgtgattccatccagcaggctacacgaaacctggaccggcga tggagaaatatctgtgctatgtccatggaaagaaggctcaaaattgaagagacgtggcga ctgtggcagaagtttctggatgactattctcgttttgaagattggctgaagacttcagaa aggacagctgccttccccagctcttctggggtgctctatacagttgccaaggaagaacta aagaaatttgaggctttccagcgccaggtccacgagagcctgactcagctggagctgatc aacaagcagtaccgccgcctggccagagagaaccgcactgactctgcgtgcagcctgaaa cagatggttcacgaaggcaaccagagatgggacaacctgcaaaagcgtgtcacctccatc ttgcgcagactcaagcatttcattggccagcgtgaggagttcgagacggcacgcgacagc attctggtgtggctgacggagatggatctgcagctcactaatatcgagcatttttctgag tgtgacgttcaagctaaaataaagcaactcaaggccttccagcaggaaatttctttgaac cacagtaagatagagcagatcattgcccagggagaacagctgatagaaaagagtgaaccc ttggatgcggccgtcattgaggaagagctggatgaactccgacgttactgtcaggaggtc ttcggccgcgtggaaagataccataagaaactgattcgcctgcccctcccagatgacgag cacgacctctctgaccgggagctggagctggatgactcggcagctctctcggacatccac tggcatgacacctctgcggacagggtgctctcccccccgccctcctcgaacccctccctc tcactcgctcagcccctccggagtgagcggtccggacgagacaccccagccagtgtggac tccatcccgctggagtgggaccatgactatgacctcagtcgtgacctggagtcggccgtg tcccgaactctgccctctgaggatgaagagggtcaggaagataaagatttctacctcggg ggagctgttggcttatcagcggatcccagcgccttagagtcacagatccgacaactggac aaagccctggatgacagccgctttcagatgcagcaaaccgaaaatatcatccgcagcaaa actcccacgggaccggagctggactcaagctacaagggctacatgaaactgctgggcgaa tgcagcggcagcatagactcagtgaggagactggaacgcaaactgagggaggaagaagag aattttcctggctttgtcaacctgaataatacggaaacccaaacagctggcgtgattgac cgatgggagctcctgcaggcacaggccctgagcaaggagctgaggatgaagcagaacctc cagaagtggcaacagttcaactctgacctgagcaacatctggacctggctgggggagatg gaggaggaactggaacagctacagcgcctggggctcagcaccgacattcagtccattgag ctccaaataaaaaagctcaaggagctccagaaagctgtggaccaacgcaaagccatcatc ctctccatcaatctgtgcagctccgagttcacccagactggcagcgaggagagccgggac ctgcaggatcgcttgtcccagatgaacgggcgctgggaccgtgtatgctcgctgctagag gagtggcggggcctgctgcaggacgctctgatgcagtgtcaggatttccatgaaatgagt catggtttgcttcttatgctggagaacatcgacagaaggaaaaatgaaattgttcctatt gattctaacctagacgcagagatacttcaggaccatcacaaacagcttacgcaaataagg cgtgagctcttggaatcgcagctcaaagtggcctcactgcaagacatgtcttgccaactg ttggtgaatgcggaaggcacagactgtttagaagccaaagaaaaagtccatgtgattgga aatcggctcaaacttctcttgaaggaggtcagtcgtcacatcaaggagctggagaagttg ttagacatgtccagcagtcagcaggatttgtcttcctggtcttctgctgatgaattggac acctcggggtctgtgagtcctacatcaggaagaagcaccccaaacaggcagagaacgcca cgaggcaaatgtagtctctcacagcctggaccctctgtcaacagtccacatagcaggtcc ataaaaggtggctccgattcctccctttctgagcctccgccagctcggtccggccgagcc ttcctgctcagagtcctccgagcggctcttccgcttcagcttctcctgctgctcctcatc gggctcgcctgccttgtaccgatgtcagaggaagactacagttgtgccctctccaacaat tttgcccgatcattccaccccatgctcagatacacaaatggccctcctccgctctga

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