Escherichia coli W: WFL_20955
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Entry
WFL_20955 CDS
T02101
Symbol
metL
Name
(GenBank) bifunctional aspartate kinase II/homoserine dehydrogenase II
KO
K12525
bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:
2.7.2.4
1.1.1.3
]
Organism
ell
Escherichia coli W
Pathway
ell00260
Glycine, serine and threonine metabolism
ell00261
Monobactam biosynthesis
ell00270
Cysteine and methionine metabolism
ell00300
Lysine biosynthesis
ell01100
Metabolic pathways
ell01110
Biosynthesis of secondary metabolites
ell01120
Microbial metabolism in diverse environments
ell01230
Biosynthesis of amino acids
Module
ell_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
ell_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
ell_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
ell00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
WFL_20955 (metL)
00270 Cysteine and methionine metabolism
WFL_20955 (metL)
00300 Lysine biosynthesis
WFL_20955 (metL)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
WFL_20955 (metL)
Enzymes [BR:
ell01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
WFL_20955 (metL)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
WFL_20955 (metL)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
HTH_11
Motif
Other DBs
NCBI-ProteinID:
AFH13833
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Position
4391274..4393706
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AA seq
810 aa
AA seq
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MSVIAQAGAKGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPDDMMVVSAAGSTTNQLINW
LKLSQTDRLSAHQVQQTLRRYQCDLISGLLPAEEADSLISAFVSDLERLAALLDSGINDA
VYAEVVGHGEVWSARLMSAVLNQQGLPAAWLDAREFLRAERAAQPQVDEGLSYPLLQQLL
VQHPGKRLVVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSEIDLQLRCSYTPDQGSTRIER
VLASGTGARIVTSHDDVCLIEFQVPASQDFKLAHKEIDQILKRAQVRPLAVGVHNDRQLL
QFCYTSEVADSALKILDEAGLPGELRLRQGLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSDDGISLVAVLRTGPTESLIQGLHQSVFRAEKRIGLVLFGKGNIGSRWLELFARE
QSTLSARTGFEFVLAGVVDSRRSLLSYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASQQLADQYLDFASHGFHVISANKLAGASDSNKYRQIHDAFEKTGRHWLYN
ATVGAGLPINHTVRDLIDSGDTILSISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGLT
EPDPRDDLSGKDVMRKLVILAREAGYNIEPDQVRVESLVPAHCEGGSIDHFFENGDELNE
QMVQRLEAAREMGLVLRYVARFDANGKARVGVEAVREDHPLASLLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq
2433 nt
NT seq
+upstream
nt +downstream
nt
atgagtgtgattgcgcaggcaggggcgaaaggtcgtcagctgcataaatttggtggcagt
agtctggctgatgtgaagtgttatttgcgtgtcgcgggcattatggcggagtactctcag
cctgacgatatgatggtggtttccgccgccggtagcaccactaaccagttgattaactgg
ttgaaactaagccagaccgatcgtctctctgcgcatcaggttcaacaaacgctgcgtcgc
tatcagtgcgatctgattagcggtctgctacccgctgaagaagccgatagcctcattagc
gcttttgtcagcgaccttgagcgcctggcggcgctgctcgacagcggtattaacgacgca
gtgtatgcggaagtggtggggcacggtgaagtgtggtcggcacgcctgatgtctgcggta
cttaatcaacaagggctgccagcggcctggcttgatgcccgcgagtttttacgcgctgaa
cgcgccgcacaaccgcaggttgatgaagggctttcttacccgttgctgcaacagctgctg
gtgcaacatccgggcaaacgtctggtggtgaccggatttatcagccgcaacaacgccggt
gaaacggtgctgctggggcgtaacggttccgactattccgcgacacaaatcggtgcgctg
gcgggtgtttctcgcgtaaccatctggagcgacgtcgccggggtatacagtgccgacccg
cgtaaagtgaaagatgcctgcctgctgccgttgctgcgtctggatgaggccagcgaactg
gcgcgcctggcggctcccgttcttcacgcccgtactttacagccggtttctggcagcgaa
atcgacctgcaactgcgctgtagctacacgccggatcaaggttccacgcgcattgaacgc
gtgctggcctccggtactggtgcgcgtattgtcaccagccacgatgatgtctgtttgatt
gagtttcaggtgcccgccagtcaggatttcaaactggcgcataaagagatcgaccaaatc
ctgaaacgcgcgcaggtacgcccgctggcggttggcgtacataacgatcgccagttgctg
caattttgctacacctcagaagtggccgacagtgcgctgaaaatcctcgacgaagcggga
ttacctggcgaactgcgcctgcgtcaggggctggcgctggtggcgatggtcggtgcaggc
gtcacccgtaacccgctgcattgccaccgcttctggcagcaactgaaaggccagccggtc
gaatttacctggcagtccgatgacggcatcagcctggtggcagtactgcgcaccggcccg
accgaaagcctgattcaggggctgcatcagtccgtcttccgcgcagaaaaacgcatcggc
ctggtattgttcggtaagggcaatatcggttcccgttggctggaactgttcgcccgtgag
cagagcacgctttcggcacgtaccggctttgagtttgtgctggcaggtgtggtggacagc
cgccgcagcctgttgagctatgacgggctggacgccagccgcgcgttagccttcttcaac
gatgaagcggttgagcaggatgaagagtcgttgttcctgtggatgcgcgcccatccgtat
gatgatttagtggtgctggacgttaccgccagccagcagcttgctgatcagtatcttgat
ttcgccagccacggtttccacgttatcagcgccaacaaactggcgggagccagcgacagc
aataaatatcgccagatccacgacgccttcgaaaaaaccgggcgtcactggctgtacaat
gccaccgtcggtgcgggcttgccgatcaaccacaccgtgcgcgatctgatcgacagcggc
gatactattttgtcgatcagcgggatcttctccggcacgctctcctggctgttcctgcaa
ttcgacggtagcgtgccgtttaccgagctggtggatcaggcgtggcagcagggcttaacc
gagcctgatccgcgtgacgacctctccggcaaagacgtaatgcgcaagctggtaattctg
gcgcgtgaagcgggttacaacattgaaccggaccaggtacgtgtggaatcgctggtgcct
gctcattgcgaaggcggcagcatcgaccatttctttgaaaatggcgatgaacttaacgag
cagatggtgcaacggctggaagcggcccgcgaaatggggctggtgctgcgctacgtggcg
cgtttcgatgccaatggcaaagcgcgtgtgggcgtggaagcggtgcgtgaagaccatccg
ctggcatcactgctgccatgcgataacgtctttgccatcgaaagccgctggtaccgcgat
aatccgctggtgatccgtgggcctggcgctgggcgcgacgtcaccgccggggcgattcag
tcggatatcaaccggctggcacagttgttgtaa
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