KEGG   Escherichia ruysiae: OSH18_20975
Entry
OSH18_20975       CDS       T09019                                 
Symbol
dfrA1
Name
(GenBank) trimethoprim-resistant dihydrofolate reductase DfrA1
  KO
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Organism
eruy  Escherichia ruysiae
Pathway
eruy00670  One carbon pool by folate
eruy00790  Folate biosynthesis
eruy01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:eruy00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    OSH18_20975 (dfrA1)
   00670 One carbon pool by folate
    OSH18_20975 (dfrA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes [BR:eruy01504]
    OSH18_20975 (dfrA1)
Enzymes [BR:eruy01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     OSH18_20975 (dfrA1)
Antimicrobial resistance genes [BR:eruy01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    OSH18_20975 (dfrA1)
SSDB
Motif
Pfam: DHFR_1 TFR_dimer
Other DBs
NCBI-ProteinID: WGM54739
LinkDB
Position
p1-S1-IND-07-A:12895..13368
AA seq 157 aa
MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
VVTRSSFTSDNENVVIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI
EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG
NT seq 474 nt   +upstreamnt  +downstreamnt
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgat
attccatggagtgccaaaggtgaacagctcctgtttaaagctattacctataaccaatgg
ctgttggttggacgcaagacttttgaatcaatgggagcattacccaaccgaaagtatgcg
gtcgtaacacgttcaagttttacatctgacaatgagaacgtagtgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggg
gagatatacaaaagcctgatcgatcaagtagatacactacatatatctacaatagacatc
gagccggaaggtgatgtttactttcctgaaatccccagcaattttaggccagtttttacc
caagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

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