KEGG   Echinops telfairi (small Madagascar hedgehog): 101650474
Entry
101650474         CDS       T08707                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
etf  Echinops telfairi (small Madagascar hedgehog)
Pathway
etf01521  EGFR tyrosine kinase inhibitor resistance
etf01522  Endocrine resistance
etf04010  MAPK signaling pathway
etf04012  ErbB signaling pathway
etf04014  Ras signaling pathway
etf04015  Rap1 signaling pathway
etf04022  cGMP-PKG signaling pathway
etf04024  cAMP signaling pathway
etf04062  Chemokine signaling pathway
etf04066  HIF-1 signaling pathway
etf04068  FoxO signaling pathway
etf04071  Sphingolipid signaling pathway
etf04072  Phospholipase D signaling pathway
etf04114  Oocyte meiosis
etf04140  Autophagy - animal
etf04148  Efferocytosis
etf04150  mTOR signaling pathway
etf04151  PI3K-Akt signaling pathway
etf04210  Apoptosis
etf04218  Cellular senescence
etf04270  Vascular smooth muscle contraction
etf04370  VEGF signaling pathway
etf04371  Apelin signaling pathway
etf04380  Osteoclast differentiation
etf04510  Focal adhesion
etf04540  Gap junction
etf04550  Signaling pathways regulating pluripotency of stem cells
etf04613  Neutrophil extracellular trap formation
etf04620  Toll-like receptor signaling pathway
etf04650  Natural killer cell mediated cytotoxicity
etf04660  T cell receptor signaling pathway
etf04662  B cell receptor signaling pathway
etf04664  Fc epsilon RI signaling pathway
etf04666  Fc gamma R-mediated phagocytosis
etf04668  TNF signaling pathway
etf04720  Long-term potentiation
etf04722  Neurotrophin signaling pathway
etf04725  Cholinergic synapse
etf04726  Serotonergic synapse
etf04730  Long-term depression
etf04810  Regulation of actin cytoskeleton
etf04910  Insulin signaling pathway
etf04912  GnRH signaling pathway
etf04914  Progesterone-mediated oocyte maturation
etf04915  Estrogen signaling pathway
etf04916  Melanogenesis
etf04917  Prolactin signaling pathway
etf04919  Thyroid hormone signaling pathway
etf04921  Oxytocin signaling pathway
etf04926  Relaxin signaling pathway
etf04928  Parathyroid hormone synthesis, secretion and action
etf04929  GnRH secretion
etf04934  Cushing syndrome
etf04935  Growth hormone synthesis, secretion and action
etf05010  Alzheimer disease
etf05022  Pathways of neurodegeneration - multiple diseases
etf05034  Alcoholism
etf05132  Salmonella infection
etf05135  Yersinia infection
etf05160  Hepatitis C
etf05161  Hepatitis B
etf05163  Human cytomegalovirus infection
etf05164  Influenza A
etf05165  Human papillomavirus infection
etf05166  Human T-cell leukemia virus 1 infection
etf05167  Kaposi sarcoma-associated herpesvirus infection
etf05170  Human immunodeficiency virus 1 infection
etf05200  Pathways in cancer
etf05205  Proteoglycans in cancer
etf05206  MicroRNAs in cancer
etf05207  Chemical carcinogenesis - receptor activation
etf05208  Chemical carcinogenesis - reactive oxygen species
etf05210  Colorectal cancer
etf05211  Renal cell carcinoma
etf05212  Pancreatic cancer
etf05213  Endometrial cancer
etf05214  Glioma
etf05215  Prostate cancer
etf05216  Thyroid cancer
etf05218  Melanoma
etf05219  Bladder cancer
etf05220  Chronic myeloid leukemia
etf05221  Acute myeloid leukemia
etf05223  Non-small cell lung cancer
etf05224  Breast cancer
etf05225  Hepatocellular carcinoma
etf05226  Gastric cancer
etf05230  Central carbon metabolism in cancer
etf05231  Choline metabolism in cancer
etf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:etf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101650474 (MAP2K1)
   04012 ErbB signaling pathway
    101650474 (MAP2K1)
   04014 Ras signaling pathway
    101650474 (MAP2K1)
   04015 Rap1 signaling pathway
    101650474 (MAP2K1)
   04370 VEGF signaling pathway
    101650474 (MAP2K1)
   04371 Apelin signaling pathway
    101650474 (MAP2K1)
   04668 TNF signaling pathway
    101650474 (MAP2K1)
   04066 HIF-1 signaling pathway
    101650474 (MAP2K1)
   04068 FoxO signaling pathway
    101650474 (MAP2K1)
   04072 Phospholipase D signaling pathway
    101650474 (MAP2K1)
   04071 Sphingolipid signaling pathway
    101650474 (MAP2K1)
   04024 cAMP signaling pathway
    101650474 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    101650474 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    101650474 (MAP2K1)
   04150 mTOR signaling pathway
    101650474 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101650474 (MAP2K1)
   04148 Efferocytosis
    101650474 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    101650474 (MAP2K1)
   04210 Apoptosis
    101650474 (MAP2K1)
   04218 Cellular senescence
    101650474 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101650474 (MAP2K1)
   04540 Gap junction
    101650474 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101650474 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101650474 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    101650474 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    101650474 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    101650474 (MAP2K1)
   04660 T cell receptor signaling pathway
    101650474 (MAP2K1)
   04662 B cell receptor signaling pathway
    101650474 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    101650474 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    101650474 (MAP2K1)
   04062 Chemokine signaling pathway
    101650474 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101650474 (MAP2K1)
   04929 GnRH secretion
    101650474 (MAP2K1)
   04912 GnRH signaling pathway
    101650474 (MAP2K1)
   04915 Estrogen signaling pathway
    101650474 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    101650474 (MAP2K1)
   04917 Prolactin signaling pathway
    101650474 (MAP2K1)
   04921 Oxytocin signaling pathway
    101650474 (MAP2K1)
   04926 Relaxin signaling pathway
    101650474 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    101650474 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    101650474 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    101650474 (MAP2K1)
   04916 Melanogenesis
    101650474 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101650474 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    101650474 (MAP2K1)
   04726 Serotonergic synapse
    101650474 (MAP2K1)
   04720 Long-term potentiation
    101650474 (MAP2K1)
   04730 Long-term depression
    101650474 (MAP2K1)
   04722 Neurotrophin signaling pathway
    101650474 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101650474 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101650474 (MAP2K1)
   05206 MicroRNAs in cancer
    101650474 (MAP2K1)
   05205 Proteoglycans in cancer
    101650474 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    101650474 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    101650474 (MAP2K1)
   05230 Central carbon metabolism in cancer
    101650474 (MAP2K1)
   05231 Choline metabolism in cancer
    101650474 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101650474 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101650474 (MAP2K1)
   05212 Pancreatic cancer
    101650474 (MAP2K1)
   05225 Hepatocellular carcinoma
    101650474 (MAP2K1)
   05226 Gastric cancer
    101650474 (MAP2K1)
   05214 Glioma
    101650474 (MAP2K1)
   05216 Thyroid cancer
    101650474 (MAP2K1)
   05221 Acute myeloid leukemia
    101650474 (MAP2K1)
   05220 Chronic myeloid leukemia
    101650474 (MAP2K1)
   05218 Melanoma
    101650474 (MAP2K1)
   05211 Renal cell carcinoma
    101650474 (MAP2K1)
   05219 Bladder cancer
    101650474 (MAP2K1)
   05215 Prostate cancer
    101650474 (MAP2K1)
   05213 Endometrial cancer
    101650474 (MAP2K1)
   05224 Breast cancer
    101650474 (MAP2K1)
   05223 Non-small cell lung cancer
    101650474 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101650474 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    101650474 (MAP2K1)
   05161 Hepatitis B
    101650474 (MAP2K1)
   05160 Hepatitis C
    101650474 (MAP2K1)
   05164 Influenza A
    101650474 (MAP2K1)
   05163 Human cytomegalovirus infection
    101650474 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101650474 (MAP2K1)
   05165 Human papillomavirus infection
    101650474 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101650474 (MAP2K1)
   05135 Yersinia infection
    101650474 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101650474 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    101650474 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    101650474 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101650474 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101650474 (MAP2K1)
   01522 Endocrine resistance
    101650474 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:etf01001]
    101650474 (MAP2K1)
Enzymes [BR:etf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     101650474 (MAP2K1)
Protein kinases [BR:etf01001]
 Serine/threonine kinases: STE group
  STE7 family
   101650474 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Haspin_kinase Kinase-like Seadorna_VP7
Other DBs
NCBI-GeneID: 101650474
NCBI-ProteinID: XP_045141667
LinkDB
Position
Unknown
AA seq 384 aa
MSWEDNLYDFRSLFDSNGTSLEALQKKLEELELDEQQRKRLEAFLTQKQQVGELKDDDFE
KISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGF
YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR
DVKPSNVLVNSRGEIRLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSM
GLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDNRPPMA
IFELLDYIVNEPPPKLPSGVFSVEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEV
DFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1155 nt   +upstreamnt  +downstreamnt
atgtcgtgggaagataatttatatgatttcagaagcctgtttgactccaatgggacgagc
ctggaggccttgcagaagaagctggaggagctggagctggacgagcagcagcggaagcgc
ctggaggcctttctgacccagaagcagcaggtgggcgagctgaaggacgacgacttcgag
aagatcagcgagctgggcgccggcaatggcggagtggtgttcaaagtctctcacaagccg
tccggcctggtcatggccagaaagctcattcacctggagatcaaaccggccatccggaat
cagatcataagggagctgcaggtgctgcatgagtgcaactcgccctacatcgtgggcttc
tacggggccttctacagcgacggggagatcagcatctgcatggagcacatggatgggggt
tccttggatcaagtcctgaagaaagccggaagaattcctgaacaaattctaggaaaagtc
agcattgctgtaatcaagggactgacctacctcagggagaaacacaagattatgcacaga
gatgtgaagccctccaacgtcctggtgaactcccgcggggagatcaggctctgcgacttt
ggggtcagcgggcagctcatcgactccatggccaactccttcgtgggcacgcgctcctac
atgtcgcccgaacgactgcagggcactcactactcggtgcagtcggatatctggagcatg
gggctctctctggtggagatggcggtgggcaggtaccccatcccccctccagatgccaag
gagctggagctgttgttcgggtgccatgtggagggagatgcagccgagaccccgcccagg
ccgaggacccctgggaggcccctcagctcttatggaatggacaaccggcctcccatggcg
atttttgagttgctggattacatcgtcaatgagcctcctccaaaactgcccagtggagtg
ttcagtgtggagtttcaagattttgtgaacaaatgcctcataaaaaaccctgccgagaga
gcagatttgaagcagctcatggttcatgctttcatcaagagatctgatgccgaagaagtg
gattttgcaggttggctctgctccaccattggccttaaccagcccagcacccccacgcac
gcagctggcgtctaa

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