Heterocephalus glaber (naked mole-rat): 101712263 Help Entry 101712263         CDS       T02812                                  Symbol Pde8b Name (RefSeq) phosphodiesterase 8B   KO K18437   high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.53] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00230   Purine metabolism hgl01100   Metabolic pathways hgl04927   Cortisol synthesis and secretion hgl04934   Cushing syndrome hgl05032   Morphine addiction Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101712263 (Pde8b)  09150 Organismal Systems   09152 Endocrine system    04927 Cortisol synthesis and secretion     101712263 (Pde8b)  09160 Human Diseases   09165 Substance dependence    05032 Morphine addiction     101712263 (Pde8b)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101712263 (Pde8b) Enzymes [BR:hgl01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.53  3',5'-cyclic-AMP phosphodiesterase      101712263 (Pde8b) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PDEase_I PDE8 PAS_9 PAS PAS_3 PAS_4 PAS_8 Motif Other DBs NCBI-GeneID:  101712263 NCBI-ProteinID:  XP_004870234 LinkDB All DBs Position Un AA seq 885 aa AA seqDB search MGCAPSIHVSQSGVIYCRDSDESNSPRQTSGVSQGPAAPLHGLFVQTDASDAVPAGRAPG PLGAVRVRRARAELGSGSSEGSTAPAGTTCRGRRRHCCASAEAETQTSYTSVQQVSSAEV RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII VIDHRQSRNFNAEAVCRSIRATNPSEHTVILAVVSPASDDHEEASVLPLLHAGFNRRFME NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER MMGYHKGELLGKELAELPKSDKNRADLLDTINTCIKKGKEWQGVYYAQRKSGDSIQQHVK ITPVIGQGGKIRHFVSLKKLCCTTDKNKQMHKIHRDSGDISQTEFHSARHKNRRKESIDV KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLVMPVTI NDVPPCITQLLDNEESWDFNVFELEAVTHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW LQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDAKCNIFKNIDRNHYRTLRQAI IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGGDCECSPVGKNFPENQILIKRMMIKCA DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS NT seq 2658 nt NT seq  +upstreamnt  +downstreamnt atgggctgcgcccccagcatccacgtctcgcagagcggcgtgatctactgccgggactca gacgagtccaactcgccccgccagacctccggcgtgtcgcagggccccgcggcgccccta cacggcctcttcgtgcagaccgacgcctccgacgccgtccccgcgggccgcgcaccggga cccctgggtgccgtccgcgtccgcagggcccgcgccgagctgggcagcggcagcagcgag ggctccacagcccccgccgggaccacctgccggggccggaggcgccactgctgcgccagc gccgaggccgagacccagaccagctacaccagcgtgcagcaggtgtcttctgcagaggtg cgcatcgggcccatgagactgacgcaggaccctattcaggttttgctaatctttgcaaag gaagatagtcagagtgatggattctggtgggcctgcgacagagctggttacagatgcaac attgctcggactccagaatcagccctcgaatgctttctagataagcatcatgaaattatt gtcattgatcacaggcagtctcggaacttcaatgcagaagcagtgtgcaggtcgatccgg gccacgaacccctcggagcacacagtgatcctcgcggtggtgtcaccagcatctgatgac catgaagaggcctcagtccttcctcttctccatgcaggcttcaaccggagatttatggag aatagcagcataattgcttgctataatgaactgattcaaatagaacatggagaagttcgc tcacagttcaagttacgggcctgtaattcagtgtttacagcattagaccactgtcatgaa gccatagaaataacaagcgatgaccacgtgattcagtatgtcaacccagccttcgagagg atgatgggctaccacaaaggggagctcctggggaaagaactggccgagctgcccaagagt gacaagaaccgggcagaccttcttgacaccatcaatacatgcatcaagaagggaaaggag tggcagggggtttactatgcccaacggaagtccggggacagcatccaacagcacgtgaag atcactccggttattggccaaggagggaaaattaggcattttgtctcactcaagaagctg tgttgtaccactgacaagaataagcagatgcacaagattcatcgtgactccggagacatt tctcagacagagtttcactccgcgcggcacaagaacaggaggaaagagtccattgatgtt aagtccatttcgtcccgaggcagtgacgccccgagcctgcagaaccgtcgctacccatcc atggcaaggatccactccatgaccatcgaagcgcccatcacgaaggttataaatatcatc aatgcagcccaagaaaacagcccagtcacagtagcagaagccttggacagagttctggaa attctacggaccacagaactctactctcctcagctgggaaccaaagatgaagacccgcac actagtgacctagttggaggcctgatgactgatgggttgagaaggttgtcaggaaatgag tatgtcttcacgaagaatgtgcaccagagtcatagtcacctcgtgatgcctgtcaccatc aatgatgtccccccgtgtatcacccagctgctcgataatgaggaaagctgggacttcaac gtctttgagctggaagcagtcacacataaaaggccattggtttacttgggcttaaaggtc ttctcccggtttggagtgtgtgaatttctaaactgctccgaaaccacccttcgggcgtgg ctccaagtgattgaagccaactaccactcctccaatgcctatcacaactccacccatgct gcggatgtcctgcacgccacggctttcttcctcggaaaggaaagagtcaagggaagcctt gaccagctggatgaggtggcagcgctgattgctgccacagtccatgatgtggatcatcct ggaaggacgaactccttcctgtgcaatgccggcagtgagctcgctgtgctctacaacgac actgcagtattggagagtcaccacacagccttggccttccagctcaccgtcaaggatgcc aaatgcaacattttcaagaacattgacaggaaccattatcgaacgctgcgccaggctatt attgacatggttttggcaacagagatgacaaaacactttgaacacgtgaacaaatttgtg aatagcatcaacaagccaatggcagctgagattgaaggtggtgactgtgagtgcagcccg gtggggaagaacttccctgaaaaccagatcctcatcaagcgcatgatgatcaagtgtgcc gacgtggcaaacccctgccgccctctggacctgtgcatcgagtgggccgggaggatctct gaagagtacttcgcacagacagatgaagagaagagacaggggctgcccgtggtgatgccc gtgtttgaccgcaacacctgcagcatccccaagtcccagatctccttcattgactacttc atcacagacatgtttgatgcttgggacgcctttgcacacctgccagccctgatgcagcac ctggctgataactacaaacactggaagacattagatgacctgaagtgcaaaagtctgagg ctgccgtcagacagctaa

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