Heterocephalus glaber (naked mole-rat): 101716937
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Entry
101716937 CDS
T02812
Symbol
Pdha1
Name
(RefSeq) pyruvate dehydrogenase (lipoamide) alpha 1
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl00010
Glycolysis / Gluconeogenesis
hgl00020
Citrate cycle (TCA cycle)
hgl00620
Pyruvate metabolism
hgl00785
Lipoic acid metabolism
hgl01100
Metabolic pathways
hgl01200
Carbon metabolism
hgl01210
2-Oxocarboxylic acid metabolism
hgl04066
HIF-1 signaling pathway
hgl04922
Glucagon signaling pathway
hgl05230
Central carbon metabolism in cancer
hgl05415
Diabetic cardiomyopathy
Module
hgl_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
101716937 (Pdha1)
00020 Citrate cycle (TCA cycle)
101716937 (Pdha1)
00620 Pyruvate metabolism
101716937 (Pdha1)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
101716937 (Pdha1)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
101716937 (Pdha1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
101716937 (Pdha1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
101716937 (Pdha1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
101716937 (Pdha1)
Enzymes [BR:
hgl01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
101716937 (Pdha1)
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Motif
Pfam:
E1_dh
DXP_synthase_N
TPP_enzyme_C
Motif
Other DBs
NCBI-GeneID:
101716937
NCBI-ProteinID:
XP_004866215
UniProt:
A0A0P6J1E9
LinkDB
All DBs
Position
Un
AA seq
390 aa
AA seq
DB search
MRKMLAAVSRVLSGAAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAHCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNNNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS
NT seq
1173 nt
NT seq
+upstream
nt +downstream
nt
atgaggaagatgcttgctgccgtctcccgcgtgttgtctggcgctgcccagaagccggca
agcagagtgctagtggcgtcccgtaattttgcaaatgatgctacatttgaaatcaagaaa
tgtgatcttcatcggctggaagagggcccacctgtcaccacagtgctcaccagggaggat
ggactcaaatactacaggatgatgcagaccgtgcgtcgaatggagttaaaggcagaccaa
ctgtataagcagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcctgc
tgtgtgggactggaggccggcataaatcctacagaccatctgatcacagcctatcgggct
catggctttaccttcactcggggcctttccgtccgggagattctagcagagctaacagga
cgaagaggaggttgtgctaaagggaaaggaggatctatgcacatgtatgccaagaacttc
tacgggggcaatggcatcgtcggagctcaggtgcccctaggagctgggattgctctggcc
tgcaagtacaatggaaaagacgaggtttgtttgacattatatggcgatggtgctgctaat
cagggtcagatatttgaagcttacaatatggcagcattatggaaattaccttgtattttc
atctgtgagaataaccgctatggaatgggaacatctgttgagcgagccgcagccagcact
gattactataagagaggcgattttattcctggactgagggtagatggaatggatatcctg
tgtgtccgagaagcaacaaggtttgcagctgcccattgtagatctgggaaggggcctatc
ttgatggagctgcagacttaccgttaccatggacatagtatgagtgatcctggagtcagt
tatcgtacacgagaagaaattcaggaagtaagaagtaagagtgaccctattatgcttctc
aaggataggatggtgaacaacaatcttgccagtgttgaagaattaaaggaaattgatgtt
gaagtgaggaaagaaatcgaggatgctgcccagttcgccacagctgatcctgagccacct
ctggaagaactaggctatcacatctacagtagcgacccaccctttgaagtgcgtggtgcc
aaccagtggatcaaattcaagtcagtcagttaa
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