Heterocephalus glaber (naked mole-rat): 101722168 Help Entry 101722168         CDS       T02812                                  Symbol Insr Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl04010   MAPK signaling pathway hgl04014   Ras signaling pathway hgl04015   Rap1 signaling pathway hgl04022   cGMP-PKG signaling pathway hgl04066   HIF-1 signaling pathway hgl04068   FoxO signaling pathway hgl04072   Phospholipase D signaling pathway hgl04150   mTOR signaling pathway hgl04151   PI3K-Akt signaling pathway hgl04152   AMPK signaling pathway hgl04211   Longevity regulating pathway hgl04213   Longevity regulating pathway - multiple species hgl04520   Adherens junction hgl04910   Insulin signaling pathway hgl04913   Ovarian steroidogenesis hgl04923   Regulation of lipolysis in adipocytes hgl04930   Type II diabetes mellitus hgl04931   Insulin resistance hgl04932   Non-alcoholic fatty liver disease hgl04960   Aldosterone-regulated sodium reabsorption hgl05010   Alzheimer disease hgl05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     101722168 (Insr)    04014 Ras signaling pathway     101722168 (Insr)    04015 Rap1 signaling pathway     101722168 (Insr)    04066 HIF-1 signaling pathway     101722168 (Insr)    04068 FoxO signaling pathway     101722168 (Insr)    04072 Phospholipase D signaling pathway     101722168 (Insr)    04022 cGMP-PKG signaling pathway     101722168 (Insr)    04151 PI3K-Akt signaling pathway     101722168 (Insr)    04152 AMPK signaling pathway     101722168 (Insr)    04150 mTOR signaling pathway     101722168 (Insr)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     101722168 (Insr)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     101722168 (Insr)    04923 Regulation of lipolysis in adipocytes     101722168 (Insr)    04913 Ovarian steroidogenesis     101722168 (Insr)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     101722168 (Insr)   09149 Aging    04211 Longevity regulating pathway     101722168 (Insr)    04213 Longevity regulating pathway - multiple species     101722168 (Insr)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101722168 (Insr)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     101722168 (Insr)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     101722168 (Insr)    04932 Non-alcoholic fatty liver disease     101722168 (Insr)    04931 Insulin resistance     101722168 (Insr)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hgl01001]     101722168 (Insr)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hgl04090]     101722168 (Insr) Enzymes [BR:hgl01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      101722168 (Insr) Protein kinases [BR:hgl01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    101722168 (Insr) CD molecules [BR:hgl04090]  Proteins   101722168 (Insr) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  101722168 NCBI-ProteinID:  XP_004865373 LinkDB All DBs Position Un AA seq 1381 aa AA seqDB search MGAWGARGAATAPLLVAAAALLVGVTGHLYPGEVCPGMDIRNNLTRLHRLENCSIIEGHL QILLMFKTKPEDFRDLSFPKLVMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTTKGKTNCPATVINGQFIERCWTHSHCQKVCPTMCKSHGCTTEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVASCPPPYYHFQDWRCVNFSFCQELHNKCKNSRRQG CHQYVIHNDRCIPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSSIRTSSDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKLQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDILYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWQ RQEEDSELYELDYCLKGLKLPSRAWSPPFESEDAQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRNPSAGSGAQDPRPSRKRRSLGEVNVTTAVPLVPGFP TLSSVSVPTNAEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDAPEERCSVAAYVS ARTMPEAKADDIVGPVTHEIFDNNAVHLMWQEPKEPNGLIVLYEVSYRRYGEEELHLCVS RKHYALEKGCRLRGLQPGNYSVRIRATSLAGNGSWTEATYFYVTNYSDVSSNIAKMIIGP LIFVFLFSIVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPCSVYVPDEWEVPRE KITLLRELGQGSFGMVYEGNAKDIVKGEAETRVAVKTVNEAASLRERIEFLNEASVMKGF TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPESENNPGRPPPTLQEMIQMAA EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC PERVTDLMRMCWQFNPKMRPTFLEIVSLLKDDLHPSFPEVSFFHSEENKAPESEELEMEF EDMENVPLDRSSHCQREEAGGREGGSSLGIKRNYEEHIPYTHMNGGKKNGRILPLPRSSP S NT seq 4146 nt NT seq  +upstreamnt  +downstreamnt atgggcgcctggggcgcgcggggggcggcgaccgcgccgctgctggtggccgcggccgcg ctgctggtgggcgtcacgggccacctgtacccgggagaggtgtgtccgggcatggacatc cggaacaacctcaccaggctgcacaggctggagaactgctccatcatcgagggacatttg cagatcctcttgatgttcaagacgaagccagaagacttccgagacctcagtttccccaaa ctggtcatgatcaccgattacttgctgctcttccgggtatatggccttgagagcctgaag gacctgttccccaacctcacggtcatccgtggctcccgcctcttcttcaactacgcgctg gtcatcttcgagatggtccatctgaaggagctggggctctacagcctcatgaacatcacg cggggctccgtgcgcatcgagaagaacaatgagctctgctacttggccaccatcgactgg tcccgcatcctggattctgtggaggacaactacatcgtgctgaacaaagatgacaatgag gagtgtggagacatctgcccaggcaccacgaagggcaagaccaactgtcccgccactgtc atcaacgggcaattcatagagcggtgctggactcacagtcactgtcagaaagtctgcccg accatgtgcaagtcccacggctgtaccaccgaaggcctctgctgtcacagcgaatgcttg ggcaactgctccgagcctgatgaccccaccaagtgtgtggcttgccgaaacttctacctg gatggcaggtgcgtggcgtcctgcccgcctccctactaccacttccaggactggcgctgt gtgaacttcagcttctgccaggagctgcacaataaatgcaagaactctcgcaggcaaggt tgccaccagtacgtcattcacaatgacaggtgcatccctgagtgtccctctgggtacacg atgaattccagcaacttgatgtgcaccccgtgcctgggcccctgccccaaggtctgtcac ctcctggaaggcgagaaaaccattgactccgtcacgtcggcgcaggagcttcgaggctgc actgtgatcaacgggagcctcatcatcaacatccggggaggcaacaacctggcagcagaa ctggaggctaacctcggcctcattgaggagatttcagggtatctaaaaatccgccgatcc tatgctcttgtatcactttccttcttccggaagttacgcttgattcgaggggaaaccttg gaaatcgggaactactctttctatgccttggacaaccagaacctaaggcagctgtgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccattataatcccaaa ctctgcctgtcagaaatccacaagatggaagaagtttcgggaaccaaggggcgccaggag aggaacgacattgccctgaagacgaacggggaccaggcatcttgtgaaaatgaattactt aaattttcatccattcggacaagttctgacaagatcttgctgagatgggagccctactgg ccccccgacttcagggacctcttaggattcatgctcttctacaaagaggccccttatcag aacgtgaccgagtttgacgggcaggatgcgtgtggctccaacagctggaccgtggtggac atcgacccgcccttgagatccaatgaccccaagttgcagaaccaccctgggtggctgatg agaggtctcaagccctggacccagtacgccatctttgtcaagaccttggtcaccttttct gacgagcgccggacgtatggggccaagagcgacatcctctacgtgcagacggatgccacc aacccgtctgtcccgctggaccccatctccgtgtcgaattcttcatcccagataattttg aagtggaagcctccctcggaccccaacggcaacatcacgcactacctggtttactggcag aggcaggaggaagacagtgagctgtacgagttggattattgcctcaaagggctgaagctg ccctcccgggcgtggtccccgcccttcgagtctgaggatgcccagaaacacaaccagagc gagtacgaggagtcggcgggcgagtgctgctcctgccccaagaccgactctcagatcctc aaggagctggaggagtcttcgttccggaagaccttcgaggattacctgcacaacgtggtc ttcgtgcccagaaatccctctgcaggcagtggtgcccaggaccctaggccctcgcggaag cgcaggtccctgggtgaggtgaatgtgaccacagcggtgcccttggtaccgggtttcccc accctctcctccgtcagcgtgcccaccaacgcggaggagcacaggcccttcgagaaggtg gtgaacaaggagtccctggtcatctctggcctgcgacacttcaccggctatcggattgag ctgcaggcctgcaaccaggatgctccggaggagaggtgcagcgtggctgcctatgtcagc gccaggaccatgcccgaagccaaggcggatgacatcgtcggccctgtgacgcacgaaatc tttgataacaacgctgttcacttgatgtggcaagaaccaaaggaacccaatggcctgatc gtgctgtatgaagtgagttatcggcggtacggggaagaggagctgcacctgtgtgtctcc cggaagcactacgccctggagaaggggtgcagactgcgggggctgcagccaggcaactac agcgtgcggatccgggccacctccctggcggggaacggctcctggacggaagccacctat ttctacgtgacaaattattcagatgtctcatcaaacattgcaaagatgatcattggtccc ctcattttcgtctttctcttcagtattgtgattgggagtatttatctattcctgaggaag agacagccggatgggccaatgggaccgctgtacgcctcctcgaaccctgagtacctcagc gccagtgacgtatttccctgttctgtgtatgtgccggacgagtgggaggtccctcgagag aagatcaccctcctgagagagctggggcagggctcctttggcatggtatacgagggaaat gccaaggacatcgtcaagggtgaggcagagactcgagtggcggtgaagacggtcaatgaa gcagccagtctccgagagaggatcgaattcctcaacgaggcctccgtcatgaaaggcttc acatgtcatcacgtggttcgcctcctgggagtggtgtccaagggccagccaacgctggtg gtgatggagttgatggcccatggagacttgaagagctacctccgctccttgcggccagag tctgagaataaccccggccgccctccccctactctacaagagatgattcagatggcggcg gagattgccgatgggatggcgtacctgaatgccaagaagtttgtgcaccgagacctggca gctcgaaactgcatggttgcccatgattttactgtcaaaatcggagactttggaatgacc agggacatctacgaaacggattactaccggaaagggggcaaaggtctgctccctgtgcgg tggatggcaccggagtccctgaaagatggggtcttcaccacttcctccgacatgtggtcc tttggtgtagtcctttgggaaatcaccagcttggcagaacagccttaccaagggctgtct aatgaacaggtgttgaaatttgtcatggatggagggtatctggaccagcctgacaattgt ccagagagagtcactgacctgatgcgcatgtgctggcagttcaaccccaagatgcggccg accttcttggagatcgtcagcctgctgaaggatgaccttcatcccagcttcccagaagtc tccttcttccacagcgaggagaacaaggcccctgagagtgaggagttggagatggagttc gaggacatggagaatgtccccttggatcggtcctcacactgtcagagggaggaggccggg ggccgggagggagggtcctcgctgggcatcaagcggaactatgaagagcacatcccgtac acccacatgaacgggggcaagaagaacgggcggatcctgcccctgccccggtccagccct tcctaa

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