Hyaena hyaena (striped hyena): 120244875 Help Entry 120244875         CDS       T07257                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism hhv  Hyaena hyaena (striped hyena) Pathway hhv04010   MAPK signaling pathway hhv04014   Ras signaling pathway hhv04015   Rap1 signaling pathway hhv04022   cGMP-PKG signaling pathway hhv04066   HIF-1 signaling pathway hhv04068   FoxO signaling pathway hhv04072   Phospholipase D signaling pathway hhv04150   mTOR signaling pathway hhv04151   PI3K-Akt signaling pathway hhv04152   AMPK signaling pathway hhv04211   Longevity regulating pathway hhv04213   Longevity regulating pathway - multiple species hhv04520   Adherens junction hhv04910   Insulin signaling pathway hhv04913   Ovarian steroidogenesis hhv04923   Regulation of lipolysis in adipocytes hhv04930   Type II diabetes mellitus hhv04931   Insulin resistance hhv04932   Non-alcoholic fatty liver disease hhv04960   Aldosterone-regulated sodium reabsorption hhv05010   Alzheimer disease hhv05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:hhv00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     120244875 (INSR)    04014 Ras signaling pathway     120244875 (INSR)    04015 Rap1 signaling pathway     120244875 (INSR)    04066 HIF-1 signaling pathway     120244875 (INSR)    04068 FoxO signaling pathway     120244875 (INSR)    04072 Phospholipase D signaling pathway     120244875 (INSR)    04022 cGMP-PKG signaling pathway     120244875 (INSR)    04151 PI3K-Akt signaling pathway     120244875 (INSR)    04152 AMPK signaling pathway     120244875 (INSR)    04150 mTOR signaling pathway     120244875 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     120244875 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     120244875 (INSR)    04923 Regulation of lipolysis in adipocytes     120244875 (INSR)    04913 Ovarian steroidogenesis     120244875 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     120244875 (INSR)   09149 Aging    04211 Longevity regulating pathway     120244875 (INSR)    04213 Longevity regulating pathway - multiple species     120244875 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     120244875 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     120244875 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     120244875 (INSR)    04932 Non-alcoholic fatty liver disease     120244875 (INSR)    04931 Insulin resistance     120244875 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hhv01001]     120244875 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hhv04090]     120244875 (INSR) Enzymes [BR:hhv01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      120244875 (INSR) Protein kinases [BR:hhv01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    120244875 (INSR) CD molecules [BR:hhv04090]  Proteins   120244875 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  120244875 NCBI-ProteinID:  XP_039107565 LinkDB All DBs Position Unknown AA seq 1369 aa AA seqDB search MGAGAGRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTADGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCRDLHVKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTTYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTNATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSDYEEAAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRPSRKRRALADVANVTAAAPTAPGFPNASTSAPTSPE EHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDAPEERCSVAAYVSARTMPEAKADDI VGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRL RGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIG SIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKITLLRELGQGS FGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVV SKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAK KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVF TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMHMCW QFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMESVPLDRAS HAQREEAGGRDGGASLGLKRNYEDHIPYTHMNGGKKNGRILTLPRSNPS NT seq 4110 nt NT seq  +upstreamnt  +downstreamnt atgggcgccggggctgggcggggggcggccgccgcgccgctgctggtggcggtggccgcg ctgctgctgggcgccgcgggccacctgtaccccggagaggtgtgtcccggcatggatatc cgaaacaacctcacgaggctgcacgagctggccaactgctcggtcatcgaaggacatttg cagatcttgctgatgttcaaaacgaggcccgaggacttccgagacctcagtttccccaaa ctcatcatgatcaccgattacttgctgctcttccgggtctacgggctggagagcctgaag gatcttttccccaacctcacggtcatccggggctcgcgcctcttcttcaactacgcgctg gtcatcttcgagatggtccatctgaaggagcttggcctctacagcttgatgaacattacc cggggctccgtccgcatcgagaagaacaacgagctgtgctacctggccactatcgactgg tcgcgcatcctggactccgtggaggataactacattgtgttgaacaaagacgacaacgag gagtgtggggacatttgtccgggcactgccaaggggaaaaccaactgccctgctactgtc atcaacggccagttcgtcgagcggtgttggactcacagccattgccagaaagtttgtccg accatctgtaagtcgcatggctgcaccgccgacggcctctgctgccacagcgagtgttta ggcaactgctcggagcccgacgaccccaccaagtgcgtggcctgtcgcaacttctacctg gacggcaggtgcgtggagacctgcccgcccccctactaccacttccaggactggcgctgc gtgaacttcagcttctgccgggacctgcacgtcaaatgcaagaactcgcggagacagggc tgccaccagtacgtcattcacaacaacaagtgcatccccgagtgcccctcggggtacacg atgaactccagcaacctgatgtgtactccatgcctgggcccctgtcccaaggtctgccac atcctggaaggcgagaagaccattgactcagtgacatctgcccaggagctccgaggctgc accgtcatcaacggaagcctaatcatcaacattcgagggggcaacaacctggcggctgag ctggaggccaacctcggactcattgaggaaatttccggatatctgaagatccgaaggtcc tatgctcttgtgtcactttcctttttccggaagttacggctcattcggggagagaccttg gaaattgggaactactctttctatgccttggacaaccagaacctgaggcagctatgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataatcccaaa ctctgcttgtcggaaattcacaagatggaggaggtttcaggaaccaaggggcgccaggag cggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaatgagctactt aaattttcttacattcggacaacttacgacaagatcttactgaagtgggagccgtactgg ccccctgacttccgagacctcctggggttcatgctcttctacaaagaggccccttatcag aacgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacggtggtggac attgacccacctctgaggtccaacgaccccaagtcacagaaccacccggggtggctgatg cggggtctcaagccctggacccagtatgccatctttgtcaagaccttggtcaccttctct gacgaacgccgcacgtatggggccaagagtgacatcatctatgtccagaccaatgctacc aacccttccgtccccctggatccaatctcggtgtctaattcctcgtctcagatcatcctg aagtggaagcctccctccgaccccaatggcaacatcacccactacctggttttctgggag aggcaggcagaagacagtgagctgtacgagctggattattgcctcaaagggttaaagctg ccttcccggacctggtctccgcccttcgagtccgagggctcccagaagcacaaccagagc gactacgaagaggctgctggcgagtgctgctcctgccccaagaccgactcgcagatcctc aaggagttggaggagtcctctttcaggaagacgtttgaggattacctgcacaacgtggtt ttcgtgcccaggccgtcgcggaagcgcagggccctcgccgacgttgcgaacgtgacggcc gccgcgcccacggctcccgggttccccaacgcctcgaccagcgcgcccaccagcccggag gagcacaagcccttcgagaaggtggtgaacaaggagtcgctggtcatctcgggcctgcgt cacttcaccggctaccgcatcgagctgcaggcgtgcaaccaggacgcccccgaggagcgg tgcagcgtggccgcctacgtcagcgccaggaccatgcccgaagccaaggcagacgatatt gttggccctgtgacccacgaaatcttcgagaacaatgtcgttcacctgatgtggcaggaa cctaaggaacccaatgggttgatcgtgctgtatgaagtgagttaccgacggtacggtgat gaggagctgcacctctgtgtctcccgtagacacttcgctctggagcggggctgcaggctg cgtgggctgccgccggggaattacagcgtgcgagttcgggccacctccctggctggcaac ggctcctggacagaagccacttatttctatgtgacagattatttagatgtcccatcgaat attgcaaaaattatcatcggccctctcatcttcgtgtttctcttcagtgttgtgattgga agtatttacctgttcctgagaaagaggcagccggatgggccactggggccgctgtatgct tcttcgaaccccgagtacctcagtgccagtgatgtgtttccctgctctgtgtatgtgccg gacgagtgggaggtgccccgggagaagatcactctcctgcgcgagctggggcagggctcc ttcggcatggtgtacgagggcaacgccagggacatcgtcaagggcgaggcggagacccgc gtggcggtgaagacggtcaatgagtctgccagtctgcgagagaggatcgagtttctcaat gaggcctcggtcatgaagggcttcacctgtcatcacgtggtccgcctcctgggggtggtg tccaaaggccagccgacgctggtggtgatggagctgatggctcacggagacctgaagagc tacctccgctccctgcggccagaggctgagaataaccccggccgccctccccctaccctg caagagatgattcagatggcggcggagatcgccgacgggatggcgtacctgaacgccaag aagtttgtgcaccgggatctcgcagctcgaaattgcatggtggcccatgatttcactgtc aaaattggagacttcggaatgaccagagacatctatgaaacggattactaccggaaggga ggcaagggtctgctccctgtgcggtggatggcgccggaatccctgaaggacggagtcttc accacttcttctgacatgtggtcctttggcgtggtcctttgggaaatcaccagcttggca gaacagccttaccagggcctgtctaatgaacaggtgttgaaatttgtcatggatggagga tatctggatcaacccgacaactgtccagagagagtcacggacctgatgcacatgtgctgg cagttcaaccccaagatgcggcccaccttcctggagatcgttgacctgctcaaggacgac ctgcaccccagctttccggaagtttccttcttccacagcgaggagaacaaggcccctgag agcgaggaattagagatggagtttgaggacatggagagcgtccccctggatcgggcctca catgctcagagggaagaggccgggggccgggatggaggggcctcgctgggcctcaagcgg aactacgaggatcatatcccctacacccacatgaatgggggcaagaaaaacggacggatt ctgactctgccgaggtcgaatccctcctaa

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