Heliomicrobium modesticaldum: HM1_1966
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Entry
HM1_1966 CDS
T00653
Symbol
cobA
Name
(GenBank) uroporphyrinogen iii synthase/methyltransferase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
hmo
Heliomicrobium modesticaldum
Pathway
hmo00860
Porphyrin metabolism
hmo01100
Metabolic pathways
hmo01110
Biosynthesis of secondary metabolites
hmo01120
Microbial metabolism in diverse environments
hmo01240
Biosynthesis of cofactors
Module
hmo_M00924
Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Brite
KEGG Orthology (KO) [BR:
hmo00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
HM1_1966 (cobA)
Enzymes [BR:
hmo01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
HM1_1966 (cobA)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
HM1_1966 (cobA)
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GFIT
Motif
Pfam:
HEM4
TP_methylase
NMT1
Motif
Other DBs
NCBI-ProteinID:
ABZ84524
UniProt:
B0TFU4
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Position
1964902..1966446
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AA seq
514 aa
AA seq
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MKQKVGKVYLVGAGPGDPGLITVKGLECIKKAEVLVYDRLAGHRLLTYARPDAELIFVGK
GPDKHVYRQEEINEVLKVKGLEGKIVTRLKGGDPFVFGRGGEEAEVLREAGVPFEIVPGI
TSAISVPAYAGIPVTHRDFTSNFAVITGNEDPTKEDSAIDWAKISTGIGTLVFLMGMGNL
PHIAAKLMEHGRSPETPVGLIRWGTRPEQRTLTGTLADIAQKAKEAAFQNPAIIIVGEVV
KLREKLAWLEEKPLFGKRIVVTRSRQQASAFAARLEEMGGEPWEFPTIDIQEPEDPAPLE
EAIAKVHEYEWIIFTSPNGVQRFFERFFAVGHDIRELCGIRLCAIGPQTRKELQKFGLKT
DFVPEEYRAEAIIEGLKNLDDWQGRKVLLPRADIARKILPEALASFGAQVDDVVAYRTVR
GGGDAVLLRQMLQDKLIHAITFTSSSTARNFVDMLGVEDVAERNALLEGVTMASIGPITS
DTMRELGLPVDVEATEYTIPGLMKALLSHWGIHE
NT seq
1545 nt
NT seq
+upstream
nt +downstream
nt
atgaagcaaaaggtagggaaggtttatctggtcggcgccggaccgggggatccgggcctc
atcaccgtgaaagggttggagtgcatcaaaaaagccgaggtgcttgtgtacgatcgcctg
gctggtcaccggttgctcacctatgcgcggcctgacgccgagctgatctttgtcggcaaa
gggccggataagcatgtctatagacaggaagagatcaacgaggtcctcaaggtcaaaggc
ctggaaggtaagatcgtcacccgtctgaaaggcggcgatcccttcgtcttcggtcgcggc
ggcgaagaagcggaggtgctccgcgaagccggcgtcccctttgaaatcgtccccggcatc
acctcggccatctccgtaccggcctatgccggcatccccgtcacccaccgcgatttcacc
tccaatttcgccgtcatcaccggcaacgaagaccctaccaaggaagactcggctatcgat
tgggccaaaatcagcaccggcatcggcaccctcgtcttcctgatgggcatgggcaatctg
ccccatatcgccgcgaagctcatggaacacggccgcagcccggaaacgccggtaggcctg
atccgctggggcacgcggccggaacagcgcaccctgacgggcaccctggctgatattgcc
cagaaggcgaaagaagccgccttccagaacccggccatcatcatcgtcggcgaagtagtc
aagctgcgcgagaaactggcctggctggaagagaaaccgctcttcggtaagcgcatcgtt
gtcacccgctcccgccagcaggcgtcggctttcgctgcccgcctggaagaaatgggtggc
gagccctgggagttccccactatcgatatccaagaaccggaggatcctgcgccgctggaa
gaagccatcgccaaggttcatgaatatgagtggatcattttcacatcccccaacggtgta
cagcggttctttgagcgcttcttcgccgtcggtcacgacatccgcgagctctgcggcatc
cgcctctgcgccatcggtccccaaacccgcaaggaactgcagaagttcggcctgaagacc
gacttcgtgccggaagaataccgcgccgaggccatcatcgaagggttgaaaaacctcgat
gattggcagggccgcaaggtgctgctacctcgggccgacattgcccgcaagatcctccct
gaagcgctggcctcctttggcgcccaggtggacgacgtggtcgcctaccggactgtccgc
ggcggcggcgacgctgttctcctccgccagatgttgcaagacaagctgatccacgccatc
accttcaccagttcctctacggctcgcaattttgtcgacatgctcggcgtagaagatgtg
gctgagcgcaatgcgctgctcgaaggcgtgaccatggcctccatcggccctatcacctcc
gatacgatgcgagaactgggcttgcctgtggacgtggaggccaccgaatacaccattccc
ggtctgatgaaggcgttgctgtcccactggggcatccacgagtga
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