Homo sapiens (human): 25939
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Entry
25939 CDS
T01001
Symbol
SAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, hSAMHD1
Name
(RefSeq) SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
KO
K22544
deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03250
Viral life cycle - HIV-1
hsa04623
Cytosolic DNA-sensing pathway
hsa05170
Human immunodeficiency virus 1 infection
Network
nt06520
CGAS-STING signaling
Element
N01573
SAMHD1-mediated dNTP degradation
Disease
H00290
Aicardi-Goutieres syndrome
H00291
Familial chilblain lupus (FCL)
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09125 Information processing in viruses
03250 Viral life cycle - HIV-1
25939 (SAMHD1)
09150 Organismal Systems
09151 Immune system
04623 Cytosolic DNA-sensing pathway
25939 (SAMHD1)
09160 Human Diseases
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
25939 (SAMHD1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins [BR:
hsa03400
]
25939 (SAMHD1)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
DSBR (double strand breaks repair)
HR (homologous recombination)
Other HR factors
25939 (SAMHD1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HD
SAM_2
SAM_1
SAM_Ste50p
PDEase_I
Motif
Other DBs
NCBI-GeneID:
25939
NCBI-ProteinID:
NP_056289
OMIM:
606754
HGNC:
15925
Ensembl:
ENSG00000101347
UniProt:
Q9Y3Z3
Q59H15
Structure
PDB
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All DBs
Position
20:complement(36889773..36951708)
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AA seq
626 aa
AA seq
DB search
MQRADSEQPSKRPRCDDSPRTPSNTPSAEADWSPGLELHPDYKTWGPEQVCSFLRRGGFE
EPVLLKNIRENEITGALLPCLDESRFENLGVSSLGERKKLLSYIQRLVQIHVDTMKVIND
PIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVH
ALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMM
FEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEI
VSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLY
DMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYT
KLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEV
ASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQL
LPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWND
STSVQNPTRLREASKSRVQLFKDDPM
NT seq
1881 nt
NT seq
+upstream
nt +downstream
nt
atgcagcgagccgattccgagcagccctccaagcgtccccgttgcgatgacagcccgaga
accccctcaaacaccccttccgcagaggcagactggtccccgggcctggaactccatccc
gactacaagacatggggtccggagcaggtgtgctccttcctcaggcgcggtggctttgaa
gagccggtgctgctgaagaacatccgagaaaatgaaatcacaggcgcattactgccttgt
cttgatgagtctcgttttgaaaatcttggagtaagttccttgggggagaggaagaagctg
cttagttatatccagcgattggttcaaatccacgttgatacaatgaaggtaattaatgat
cctatccatggccacattgagctccaccctctcctcgtccgaatcattgatacacctcaa
tttcaacgtcttcgatacatcaaacagctgggaggtggttactatgtttttccaggagct
tcacacaatcgatttgagcatagtctaggggtggggtatctagcaggatgtctagttcac
gcactgggtgaaaaacaaccagagctgcagataagtgaacgagatgttctctgtgttcag
attgctggactttgtcatgatctcggtcatgggccattttctcacatgtttgatggacga
tttattccacttgctcgcccggaggtgaaatggacgcatgaacaaggctcagttatgatg
tttgagcaccttattaattctaatggaattaagcctgtcatggaacaatatggtctcatc
cctgaagaagatatttgctttataaaggaacaaattgtaggaccacttgaatcacctgtc
gaagattcattgtggccatataaagggcgtcctgaaaacaaaagcttcctttatgagata
gtatctaataaaagaaatggcattgatgtggacaaatgggattattttgccagggactgc
catcatcttggaatccaaaataattttgattacaagcgctttattaagtttgcccgtgtc
tgtgaagtagacaatgagttgcgtatttgtgctagagataaggaagttggaaatctgtat
gacatgttccacactcgcaactctttacaccgtagagcttatcaacacaaagttggcaac
attattgatacaatgattacagatgctttcctcaaagcagatgactacatagagattaca
ggtgctggaggaaaaaagtatcgcatttctacagcaattgacgacatggaagcctatact
aagctgacagataacatttttctggagattttatactctactgatcccaaattgaaagac
gcacgagagattttaaaacaaattgaataccgtaatctattcaagtatgtgggtgagacg
cagccaacaggacaaataaagattaaaagggaggactatgaatctcttccaaaagaggtt
gccagtgctaaacccaaagtattgctagacgtgaaactgaaggctgaagattttatagtg
gatgttatcaacatggattatggaatgcaagaaaagaatccaattgatcatgttagcttc
tattgtaagactgcccccaacagagcaatcaggattactaaaaaccaggtttcacaactt
ctgccagagaaatttgcagagcagctgattcgagtatattgtaagaaggtggacagaaag
agtttgtatgccgcaagacaatattttgttcagtggtgtgcagacagaaatttcaccaag
ccgcaggatggcgatgttatagccccactcataacacctcaaaaaaaggaatggaacgac
agtacttcagtccaaaatccaactcgcctccgagaagcatccaaaagcagagtccagctt
tttaaagatgacccaatgtga
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