Homo sapiens (human): 4067
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Entry
4067 CDS
T01001
Symbol
LYN, JTK8, SAIDV, p53Lyn, p56Lyn
Name
(RefSeq) LYN proto-oncogene, Src family tyrosine kinase
KO
K05854
tyrosine-protein kinase Lyn [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04062
Chemokine signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04611
Platelet activation
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa04730
Long-term depression
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05169
Epstein-Barr virus infection
hsa05203
Viral carcinogenesis
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06165
Epstein-Barr virus (EBV)
nt06220
Calcium signaling (cancer)
nt06533
Chemokine signaling
nt06537
TCR/BCR signaling
Element
N00266
EBV LMP2A to PI3K signaling pathway
N00487
BCR-PLCG-Calcineurin signaling pathway
N00488
EBV LMP2A to BCR signaling pathway
N01695
BCR-BCAP/CD19-PI3K signaling pathway
N01767
CXCR4-GNAI-Src signaling pathway
Disease
H02672
Systemic autoinflammatory disease with vasculitis
Drug target
Bafetinib:
D10202
Tolimidone:
D06182
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
4067 (LYN)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
4067 (LYN)
04662 B cell receptor signaling pathway
4067 (LYN)
04664 Fc epsilon RI signaling pathway
4067 (LYN)
04666 Fc gamma R-mediated phagocytosis
4067 (LYN)
04062 Chemokine signaling pathway
4067 (LYN)
09156 Nervous system
04730 Long-term depression
4067 (LYN)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
4067 (LYN)
09172 Infectious disease: viral
05167 Kaposi sarcoma-associated herpesvirus infection
4067 (LYN)
05169 Epstein-Barr virus infection
4067 (LYN)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
4067 (LYN)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
4067 (LYN)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
4067 (LYN)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
4067 (LYN)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
4067 (LYN)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SRC family
4067 (LYN)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
4067 (LYN)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_2
SH3_9
SH3_3
ABC1
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
4067
NCBI-ProteinID:
NP_002341
OMIM:
165120
HGNC:
6735
Ensembl:
ENSG00000254087
UniProt:
P07948
Q6NUK7
A8K379
Structure
PDB
LinkDB
All DBs
Position
8:55879835..56014169
Genome browser
AA seq
512 aa
AA seq
DB search
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
NT seq
1539 nt
NT seq
+upstream
nt +downstream
nt
atgggatgtataaaatcaaaagggaaagacagcttgagtgacgatggagtagatttgaag
actcaaccagtacgtaatactgaaagaactatttatgtgagagatccaacgtccaataaa
cagcaaaggccagttccagaatctcagcttttacctggacagaggtttcaaactaaagat
ccagaggaacaaggagacattgtggtagccttgtacccctatgatggcatccacccggac
gacttgtctttcaagaaaggagagaagatgaaagtcctggaggagcatggagaatggtgg
aaagcaaagtcccttttaacaaaaaaagaaggcttcatccccagcaactatgtggccaaa
ctcaacaccttagaaacagaagagtggtttttcaaggatataaccaggaaggacgcagaa
aggcagcttttggcaccaggaaatagcgctggagctttccttattagagaaagtgaaaca
ttaaaaggaagcttctctctgtctgtcagagactttgaccctgtgcatggtgatgttatt
aagcactacaaaattagaagtctggataatgggggctattacatctctccacgaatcact
tttccctgtatcagcgacatgattaaacattaccaaaagcaggcagatggcttgtgcaga
agattggagaaggcttgtattagtcccaagccacagaagccatgggataaagatgcctgg
gagatcccccgggagtccatcaagttggtgaaaaggcttggcgctgggcagtttggggaa
gtctggatgggttactataacaacagtaccaaggtggctgtgaaaaccctgaagccagga
actatgtctgtgcaagccttcctggaagaagccaacctcatgaagaccctgcagcatgac
aagctcgtgaggctctacgctgtggtcaccagggaggagcccatttacatcatcaccgag
tacatggccaagggcagtttgctggatttcctgaagagcgatgaaggtggcaaagtgctg
cttccaaagctcattgacttttctgctcagattgcagagggaatggcatacatcgagcgg
aagaactacattcaccgggacctgcgagcagctaatgttctggtctccgagtcactcatg
tgcaaaattgcagattttggccttgctagagtaattgaagataatgagtacacagcaagg
gaaggtgctaagttccctattaagtggacggctccagaagcaatcaactttggatgtttc
actattaagtctgatgtgtggtcctttggaatcctcctatacgaaattgtcacctatggg
aaaattccctacccagggagaactaatgccgacgtgatgaccgccctgtcccagggctac
aggatgccccgtgtggagaactgcccagatgagctctatgacattatgaaaatgtgctgg
aaagaaaaggcagaagagagaccaacgtttgactacttacagagcgtcctggatgatttc
tacacagccacggaagggcaataccagcagcagccttag
Homo sapiens (human): 6850
Help
Entry
6850 CDS
T01001
Symbol
SYK, IMD82, p72-Syk
Name
(RefSeq) spleen associated tyrosine kinase
KO
K05855
spleen tyrosine kinase [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04064
NF-kappa B signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04380
Osteoclast differentiation
hsa04611
Platelet activation
hsa04613
Neutrophil extracellular trap formation
hsa04625
C-type lectin receptor signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa05152
Tuberculosis
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05171
Coronavirus disease - COVID-19
hsa05203
Viral carcinogenesis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06165
Epstein-Barr virus (EBV)
nt06220
Calcium signaling (cancer)
nt06537
TCR/BCR signaling
Element
N00266
EBV LMP2A to PI3K signaling pathway
N00487
BCR-PLCG-Calcineurin signaling pathway
N00488
EBV LMP2A to BCR signaling pathway
N01695
BCR-BCAP/CD19-PI3K signaling pathway
Disease
H02526
Disorders of adaptive immunity
Drug target
Entospletinib:
D11209
Fostamatinib (
DG01419
):
D09347
D09348
<JP/US>
Gusacitinib (
DG03080
):
D11676
D11677
Mivavotinib (
DG03106
):
D11789
D11790
Tuspetinib:
D12476
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
6850 (SYK)
04072 Phospholipase D signaling pathway
6850 (SYK)
04151 PI3K-Akt signaling pathway
6850 (SYK)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
6850 (SYK)
04613 Neutrophil extracellular trap formation
6850 (SYK)
04625 C-type lectin receptor signaling pathway
6850 (SYK)
04650 Natural killer cell mediated cytotoxicity
6850 (SYK)
04662 B cell receptor signaling pathway
6850 (SYK)
04664 Fc epsilon RI signaling pathway
6850 (SYK)
04666 Fc gamma R-mediated phagocytosis
6850 (SYK)
09158 Development and regeneration
04380 Osteoclast differentiation
6850 (SYK)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
6850 (SYK)
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
6850 (SYK)
05168 Herpes simplex virus 1 infection
6850 (SYK)
05167 Kaposi sarcoma-associated herpesvirus infection
6850 (SYK)
05169 Epstein-Barr virus infection
6850 (SYK)
09171 Infectious disease: bacterial
05152 Tuberculosis
6850 (SYK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
6850 (SYK)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
6850 (SYK)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SYK family
6850 (SYK)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
Kdo
ABC1
Motif
Other DBs
NCBI-GeneID:
6850
NCBI-ProteinID:
NP_001167638
OMIM:
600085
HGNC:
11491
Ensembl:
ENSG00000165025
UniProt:
P43405
Structure
PDB
LinkDB
All DBs
Position
9:90801600..90898549
Genome browser
AA seq
635 aa
AA seq
DB search
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
NT seq
1908 nt
NT seq
+upstream
nt +downstream
nt
atggccagcagcggcatggctgacagcgccaaccacctgcccttctttttcggcaacatc
acccgggaggaggcagaagattacctggtccaggggggcatgagtgatgggctttatttg
ctgcgccagagccgcaactacctgggtggcttcgccctgtccgtggcccacgggaggaag
gcacaccactacaccatcgagcgggagctgaatggcacctacgccatcgccggtggcagg
acccatgccagccccgccgacctctgccactaccactcccaggagtctgatggcctggtc
tgcctcctcaagaagcccttcaaccggccccaaggggtgcagcccaagactgggcccttt
gaggatttgaaggaaaacctcatcagggaatatgtgaagcagacatggaacctgcagggt
caggctctggagcaggccatcatcagtcagaagcctcagctggagaagctgatcgctacc
acagcccatgaaaaaatgccttggttccatggaaaaatctctcgggaagaatctgagcaa
attgtcctgataggatcaaagacaaatggaaagttcctgatccgagccagagacaacaac
ggctcctacgccctgtgcctgctgcacgaagggaaggtgctgcactatcgcatcgacaaa
gacaagacagggaagctctccatccccgagggaaagaagttcgacacgctctggcagcta
gtcgagcattattcttataaagcagatggtttgttaagagttcttactgtcccatgtcaa
aaaatcggcacacagggaaatgttaattttggaggccgtccacaacttccaggttcccat
cctgcgacttggtcagcgggtggaataatctcaagaatcaaatcatactccttcccaaag
cctggccacagaaagtcctcccctgcccaagggaaccggcaagagagtactgtgtcattc
aatccgtatgagccagaacttgcaccctgggctgcagacaaaggcccccagagagaagcc
ctacccatggacacagaggtgtacgagagcccctacgcggaccccgaggagatcaggccc
aaggaggtttacctggaccgaaagctgctgacgctggaagacaaagaactgggctctggt
aattttggaactgtgaaaaagggctactaccaaatgaaaaaagttgtgaaaaccgtggct
gtgaaaatactgaaaaacgaggccaatgaccccgctcttaaagatgagttattagcagaa
gcaaatgtcatgcagcagctggacaacccgtacatcgtgcggatgatcgggatatgcgag
gccgagtcctggatgctggttatggagatggcagaacttggtcccctcaataagtatttg
cagcagaacagacatgtcaaggataagaacatcatagaactggttcatcaggtttccatg
ggcatgaagtacttggaggagagcaattttgtgcacagagatctggctgcaagaaatgtg
ttgctagttacccaacattacgccaagatcagtgatttcggactttccaaagcactgcgt
gctgatgaaaactactacaaggcccagacccatggaaagtggcctgtcaagtggtacgct
ccggaatgcatcaactactacaagttctccagcaaaagcgatgtctggagctttggagtg
ttgatgtgggaagcattctcctatgggcagaagccatatcgagggatgaaaggaagtgaa
gtcaccgctatgttagagaaaggagagcggatggggtgccctgcagggtgtccaagagag
atgtacgatctcatgaatctgtgctggacatacgatgtggaaaacaggcccggattcgca
gcagtggaactgcggctgcgcaattactactatgacgtggtgaactaa
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