Homo sapiens (human): 50940
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Entry
50940 CDS
T01001
Symbol
PDE11A, PPNAD2
Name
(RefSeq) phosphodiesterase 11A
KO
K13298
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 [EC:
3.1.4.17
3.1.4.35
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04934
Cushing syndrome
hsa05032
Morphine addiction
Network
nt06310
CRH-ACTH-cortisol signaling
nt06360
Cushing syndrome
Element
N00323
Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
Disease
H00260
Pigmented micronodular adrenocortical disease
H01431
Cushing syndrome
H02049
Bilateral macronodular adrenal hyperplasia
Drug target
Aminophylline (
DG01062
):
D00227
D05429
<JP>
D11630
<US>
Bemoradan:
D03075
Bucladesine (
DG00230
):
D01238
<JP>
D07546
Choline theophyllinate:
D02017
Diprophylline:
D00691
<JP>
Enprofylline:
D04006
Flavoxate (
DG00477
):
D00718
<JP/US>
D07961
Moxaverine (
DG00045
):
D07089
D08238
Oxagrelate:
D05278
Papaverine (
DG00043
):
D02218
<JP>
D07425
D07439
Prinoxodan:
D05612
Proxyphylline:
D01771
<JP>
Theophylline (
DG01061
):
D00371
<JP/US>
D01712
D06103
D06104
Theosalicin:
D09822
Tibenelast sodium:
D06132
Trapidil:
D01220
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
50940 (PDE11A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
50940 (PDE11A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
50940 (PDE11A)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
50940 (PDE11A)
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
50940 (PDE11A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDEase_I
GAF
GAF_2
GAF_3
HD
Motif
Other DBs
NCBI-GeneID:
50940
NCBI-ProteinID:
NP_058649
OMIM:
604961
HGNC:
8773
Ensembl:
ENSG00000128655
UniProt:
Q9HCR9
LinkDB
All DBs
Position
2:complement(177623244..178108339)
Genome browser
AA seq
933 aa
AA seq
DB search
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
NT seq
2802 nt
NT seq
+upstream
nt +downstream
nt
atggcagcctcccgcctggactttggggaggtggaaactttcctggacaggcacccagag
ttgtttgaagattacttgatgcggaaggggaagcaggagatggttgaaaagtggctgcag
aggcacagtcagggtcagggggctttaggtccaaggccctctttggctggtaccagcagc
ttggctcacagcacctgcagaggtggcagcagcgttggtggtggcactggaccaaatggc
tctgcccacagccagccccttcccggtggcggggactgtggtggggttcccttgagtccc
agctgggccggtggcagcaggggcgatgggaacctgcagcggagagcttctcagaaagag
ctaaggaagagttttgcccgctccaaggccatccacgtgaacaggacctacgatgaacag
gtgacctcccgggctcaggaacccctgagtagtgtacgacggagggcacttctccggaag
gcaagctccctgccccccaccacagcccatattctcagtgcgctgctggaatcgagagtg
aatctgcctcggtatccccctacagccatcgactacaagtgccatctgaaaaagcataat
gagcgtcagttctttctggaattggtcaaagatatctccaatgaccttgacctcaccagc
ctgagctacaagattctcatctttgtctgccttatggtggatgctgaccgctgctctctt
ttcctggtggaaggggcagctgctggcaagaagaccttggtctccaaattctttgatgtg
catgcaggaacacctctgctgccttgcagcagcacagagaactcaaatgaggtgcaggtc
ccctggggcaaaggtatcattggctatgtcggggagcatggagaaacggtcaacattcct
gatgcctaccaggatcgacgattcaatgatgaaatcgacaagctaactggatacaagaca
aaatcattattgtgcatgcctatccgaagcagtgatggtgagattattggtgtggcccaa
gcgataaataagattcctgaaggagctccatttactgaagatgatgaaaaagttatgcag
atgtatcttccattttgtggaatcgccatatctaacgctcagctctttgctgcctcaagg
aaagaatatgaaagaagcagagctttgctagaggtggttaatgacctctttgaagaacag
actgacctggagaaaattgtcaagaaaataatgcatcgggcccaaactctgctgaaatgt
gaacgctgttctgttttactcctagaggacatcgaatcaccagtggtgaaatttaccaaa
tcctttgaattgatgtccccaaagtgcagtgctgatgctgagaacagtttcaaagaaagc
atggagaaatcatcatactccgactggctaataaataacagcattgctgagctggttgct
tcaacaggccttccagtgaacatcagtgatgcctaccaggatccgcgctttgatgcagag
gcagaccagatatctggttttcacataagatctgttctttgtgtccctatttggaatagc
aaccaccaaataattggagtggctcaagtgttaaacagacttgatgggaaaccttttgat
gatgcagatcaacgactttttgaggcttttgtcatcttttgtggacttggcatcaacaac
acaattatgtatgatcaagtgaagaagtcctgggccaagcagtctgtggctcttgatgtg
ctatcataccatgcaacatgttcaaaagctgaagttgacaagtttaaggcagccaacatc
cctctggtgtcagaacttgccatcgatgacattcattttgatgacttttctctcgacgtt
gatgccatgatcacagctgctctccggatgttcatggagctggggatggtacagaaattt
aaaattgactatgagacactgtgtaggtggcttttgacagtgaggaaaaactatcggatg
gttctataccacaactggagacatgccttcaacgtgtgtcagctgatgttcgcgatgtta
accactgctgggtttcaagacattctgaccgaggtggaaattttagcggtgattgtggga
tgcctgtgtcatgacctcgaccacaggggaaccaacaatgccttccaagctaagagtggc
tctgccctggcccaactctatggaacctctgctaccttggagcatcaccatttcaaccac
gccgtgatgatccttcaaagtgagggtcacaatatctttgctaacctgtcctccaaggaa
tatagtgaccttatgcagcttttgaagcagtcaatattggcaacagacctcacgctgtac
tttgagaggagaactgaattctttgaacttgtcagtaaaggagaatacgattggaacatc
aaaaaccatcgtgatatatttcgatcaatgttaatgacagcctgtgaccttggagccgtg
accaaaccgtgggagatctccagacaggtggcagaacttgtaaccagtgagttcttcgaa
caaggagatcgggagagattagagctcaaactcactccttcagcaatttttgatcggaac
cggaaggatgaactgcctcggttgcaactggagtggattgatagcatctgcatgcctttg
tatcaggcactggtgaaggtcaacgtgaaactgaagccgatgctagattcagtagctaca
aacagaagtaagtgggaagagctacaccaaaaacgactgctggcctcaactgcctcatcc
tcccctgccagtgttatggtagccaaggaagacaggaactaa
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