Homo sapiens (human): 5150
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Entry
5150 CDS
T01001
Symbol
PDE7A, HCP1, PDE7
Name
(RefSeq) phosphodiesterase 7A
KO
K18436
high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 [EC:
3.1.4.53
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa05032
Morphine addiction
Drug target
Aminophylline (
DG01062
):
D00227
D05429
<JP>
D11630
<US>
Bemoradan:
D03075
Bucladesine (
DG00230
):
D01238
<JP>
D07546
Choline theophyllinate:
D02017
Diprophylline:
D00691
<JP>
Enprofylline:
D04006
Flavoxate (
DG00477
):
D00718
<JP/US>
D07961
Moxaverine (
DG00045
):
D07089
D08238
Oxagrelate:
D05278
Papaverine (
DG00043
):
D02218
<JP>
D07425
D07439
Prinoxodan:
D05612
Proxyphylline:
D01771
<JP>
Theophylline (
DG01061
):
D00371
<JP/US>
D01712
D06103
D06104
Theosalicin:
D09822
Tibenelast sodium:
D06132
Trapidil:
D01220
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5150 (PDE7A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
5150 (PDE7A)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
5150 (PDE7A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDEase_I
Motif
Other DBs
NCBI-GeneID:
5150
NCBI-ProteinID:
NP_001229247
OMIM:
171885
HGNC:
8791
Ensembl:
ENSG00000205268
UniProt:
Q13946
Structure
PDB
LinkDB
All DBs
Position
8:complement(65714334..65842064)
Genome browser
AA seq
482 aa
AA seq
DB search
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
NT seq
1449 nt
NT seq
+upstream
nt +downstream
nt
atggaagtgtgttaccagctgccggtactgcccctggacaggccggtcccccagcacgtc
ctcagccgccgaggagccatcagcttcagctccagctccgctctcttcggctgccccaat
ccccggcagctctctcagaggcgtggagctatttcctatgacagttctgatcagactgca
ttatacattcgtatgctaggagatgtacgtgtaaggagccgagcaggatttgaatcagaa
agaagaggttctcacccatatattgattttcgtattttccactctcaatctgaaattgaa
gtgtctgtctctgcaaggaatatcagaaggctactaagtttccagcgatatcttagatct
tcacgcttttttcgtggtactgcggtttcaaattccctaaacattttagatgatgattat
aatggacaagccaagtgtatgctggaaaaagttggaaattggaattttgatatctttcta
tttgatagactaacaaatggaaatagtctagtaagcttaacctttcatttatttagtctt
catggattaattgagtacttccatttagatatgatgaaacttcgtagatttttagttatg
attcaagaagattaccacagtcaaaatccttaccataacgcagtccacgctgcggatgtt
actcaggccatgcactgttacttaaaggaacctaagcttgccaattctgtaactccttgg
gatatcttgctgagcttaattgcagctgccactcatgatctggatcatccaggtgttaat
caacctttccttattaaaactaaccattacttggcaactttatacaagaatacctcagta
ctggaaaatcaccactggagatctgcagtgggcttattgagagaatcaggcttattctca
catctgccattagaaagcaggcaacaaatggagacacagataggtgctctgatactagcc
acagacatcagtcgccagaatgagtatctgtctttgtttaggtcccatttggatagaggt
gatttatgcctagaagacaccagacacagacatttggttttacagatggctttgaaatgt
gctgatatttgtaacccatgtcggacgtgggaattaagcaagcagtggagtgaaaaagta
acggaggaattcttccatcaaggagatatagaaaaaaaatatcatttgggtgtgagtcca
ctttgcgatcgtcacactgaatctattgccaacatccagattggttttatgacttaccta
gtggagcctttatttacagaatgggccaggttttccaatacaaggctatcccagacaatg
cttggacacgtggggctgaataaagccagctggaagggactgcagagagaacagtcgagc
agtgaggacactgatgctgcatttgagttgaactcacagttattacctcaggaaaatcgg
ttatcataa
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