Homo sapiens (human): 5879
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Entry
5879 CDS
T01001
Symbol
RAC1, MIG5, MRD48, Rac-1, TC-25, p21-Rac1
Name
(RefSeq) Rac family small GTPase 1
KO
K04392
Ras-related C3 botulinum toxin substrate 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04024
cAMP signaling pathway
hsa04062
Chemokine signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04145
Phagosome
hsa04148
Efferocytosis
hsa04151
PI3K-Akt signaling pathway
hsa04310
Wnt signaling pathway
hsa04360
Axon guidance
hsa04370
VEGF signaling pathway
hsa04380
Osteoclast differentiation
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04530
Tight junction
hsa04613
Neutrophil extracellular trap formation
hsa04620
Toll-like receptor signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04662
B cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa04670
Leukocyte transendothelial migration
hsa04722
Neurotrophin signaling pathway
hsa04810
Regulation of actin cytoskeleton
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04972
Pancreatic secretion
hsa05014
Amyotrophic lateral sclerosis
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05100
Bacterial invasion of epithelial cells
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05135
Yersinia infection
hsa05163
Human cytomegalovirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05205
Proteoglycans in cancer
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05231
Choline metabolism in cancer
hsa05415
Diabetic cardiomyopathy
hsa05416
Viral myocarditis
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06167
Human cytomegalovirus (HCMV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06224
CXCR signaling (cancer)
nt06465
Prion disease
nt06521
NLR signaling
nt06535
Efferocytosis
Element
N00153
CCR/CXCR-GNB/G-PI3K-RAC signaling pathway
N00394
HCMV gH to ITGA/B-RhoA signaling pathway
N00433
CXCR4-GNB/G-RAC signaling pathway
N00951
ITGA/B-RHOG-RAC signaling pathway
N00952
Shigella IpgB1 to ITGA/B-RHOG-RAC signaling pathway
N01068
ITGA/B-FAK-RAC signaling pathway
N01069
Shigella IpgB1 to ITGA/B-FAK-RAC signaling pathway
N01077
Shigella IcsB to ITGA/B-FAK-RAC signaling pathway
N01086
Escherichia EspT to RAC signaling pathway
N01087
Escherichia EspW to RAC signaling pathway
N01090
IGG-FCGR-RAC signaling pathway
N01102
Yersinia YopE to ITGA/B-RHOG-RAC signaling pathway
N01103
Yersinia YpkA to IGG-FCGR-RAC signaling pathway
N01119
RAC/CDC42-PAK-ERK signaling pathway
N01120
Salmonella SptP to RAC/CDC42-PAK-ERK signaling pathway
N01127
Salmonella SopE to Inflammasome signaling pathway
N01128
Salmonella SopE to RAC signaling pathway
N01204
PRNP-PI3K-NOX2 signaling pathway
N01205
Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
N01761
Activation of CRK-DOCK-Rac1 pathway
N01763
MEGF10-mediated recognition and engulfment
N01779
Continual efferocytosis enhanced by the AC-derived arginine and ornithine
Disease
H00773
Autosomal dominant intellectual developmental disorder
Drug target
Plitidepsin:
D11032
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
5879 (RAC1)
04014 Ras signaling pathway
5879 (RAC1)
04015 Rap1 signaling pathway
5879 (RAC1)
04310 Wnt signaling pathway
5879 (RAC1)
04370 VEGF signaling pathway
5879 (RAC1)
04071 Sphingolipid signaling pathway
5879 (RAC1)
04024 cAMP signaling pathway
5879 (RAC1)
04151 PI3K-Akt signaling pathway
5879 (RAC1)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
5879 (RAC1)
04148 Efferocytosis
5879 (RAC1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
5879 (RAC1)
04520 Adherens junction
5879 (RAC1)
04530 Tight junction
5879 (RAC1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
5879 (RAC1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
5879 (RAC1)
04620 Toll-like receptor signaling pathway
5879 (RAC1)
04650 Natural killer cell mediated cytotoxicity
5879 (RAC1)
04662 B cell receptor signaling pathway
5879 (RAC1)
04664 Fc epsilon RI signaling pathway
5879 (RAC1)
04666 Fc gamma R-mediated phagocytosis
5879 (RAC1)
04670 Leukocyte transendothelial migration
5879 (RAC1)
04062 Chemokine signaling pathway
5879 (RAC1)
09154 Digestive system
04972 Pancreatic secretion
5879 (RAC1)
09156 Nervous system
04722 Neurotrophin signaling pathway
5879 (RAC1)
09158 Development and regeneration
04360 Axon guidance
5879 (RAC1)
04380 Osteoclast differentiation
5879 (RAC1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5879 (RAC1)
05205 Proteoglycans in cancer
5879 (RAC1)
05208 Chemical carcinogenesis - reactive oxygen species
5879 (RAC1)
05203 Viral carcinogenesis
5879 (RAC1)
05231 Choline metabolism in cancer
5879 (RAC1)
09162 Cancer: specific types
05210 Colorectal cancer
5879 (RAC1)
05212 Pancreatic cancer
5879 (RAC1)
05211 Renal cell carcinoma
5879 (RAC1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
5879 (RAC1)
05163 Human cytomegalovirus infection
5879 (RAC1)
05167 Kaposi sarcoma-associated herpesvirus infection
5879 (RAC1)
05169 Epstein-Barr virus infection
5879 (RAC1)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
5879 (RAC1)
05130 Pathogenic Escherichia coli infection
5879 (RAC1)
05132 Salmonella infection
5879 (RAC1)
05131 Shigellosis
5879 (RAC1)
05135 Yersinia infection
5879 (RAC1)
05100 Bacterial invasion of epithelial cells
5879 (RAC1)
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
5879 (RAC1)
05020 Prion disease
5879 (RAC1)
05022 Pathways of neurodegeneration - multiple diseases
5879 (RAC1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
5879 (RAC1)
05418 Fluid shear stress and atherosclerosis
5879 (RAC1)
05415 Diabetic cardiomyopathy
5879 (RAC1)
05416 Viral myocarditis
5879 (RAC1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
5879 (RAC1)
04933 AGE-RAGE signaling pathway in diabetic complications
5879 (RAC1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
5879 (RAC1)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
5879 (RAC1)
04031 GTP-binding proteins [BR:
hsa04031
]
5879 (RAC1)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Small GTPases and associated proteins
Rho GTPases
5879 (RAC1)
Endocytosis
Lipid raft mediated endocytosis
Arf6-dependent endocytosis
5879 (RAC1)
Macropinocytosis
Ras GTPases
5879 (RAC1)
Others
NADPH oxidases (Nox) and associated proteins
Nox associated proteins
5879 (RAC1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
5879 (RAC1)
Exosomal proteins of other body fluids (saliva and urine)
5879 (RAC1)
Exosomal proteins of colorectal cancer cells
5879 (RAC1)
Exosomal proteins of bladder cancer cells
5879 (RAC1)
GTP-binding proteins [BR:
hsa04031
]
Small (monomeric) G-proteins
Rho Family
Rac/Cdc42 [OT]
5879 (RAC1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ras
Roc
Arf
GTP_EFTU
CagD
Motif
Other DBs
NCBI-GeneID:
5879
NCBI-ProteinID:
NP_008839
OMIM:
602048
HGNC:
9801
Ensembl:
ENSG00000136238
UniProt:
P63000
A4D2P1
Structure
PDB
LinkDB
All DBs
Position
7:6374527..6403967
Genome browser
AA seq
192 aa
AA seq
DB search
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG
QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR
DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP
PVKKRKRKCLLL
NT seq
579 nt
NT seq
+upstream
nt +downstream
nt
atgcaggccatcaagtgtgtggtggtgggagacggagctgtaggtaaaacttgcctactg
atcagttacacaaccaatgcatttcctggagaatatatccctactgtctttgacaattat
tctgccaatgttatggtagatggaaaaccggtgaatctgggcttatgggatacagctgga
caagaagattatgacagattacgccccctatcctatccgcaaacagatgtgttcttaatt
tgcttttcccttgtgagtcctgcatcatttgaaaatgtccgtgcaaagtggtatcctgag
gtgcggcaccactgtcccaacactcccatcatcctagtgggaactaaacttgatcttagg
gatgataaagacacgatcgagaaactgaaggagaagaagctgactcccatcacctatccg
cagggtctagccatggctaaggagattggtgctgtaaaatacctggagtgctcggcgctc
acacagcgaggcctcaagacagtgtttgacgaagcgatccgagcagtcctctgcccgcct
cccgtgaagaagaggaagagaaaatgcctgctgttgtaa
Homo sapiens (human): 998
Help
Entry
998 CDS
T01001
Symbol
CDC42, CDC42Hs, G25K, TKS
Name
(RefSeq) cell division cycle 42
KO
K04393
cell division control protein 42
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04062
Chemokine signaling pathway
hsa04144
Endocytosis
hsa04360
Axon guidance
hsa04370
VEGF signaling pathway
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04530
Tight junction
hsa04660
T cell receptor signaling pathway
hsa04666
Fc gamma R-mediated phagocytosis
hsa04670
Leukocyte transendothelial migration
hsa04722
Neurotrophin signaling pathway
hsa04810
Regulation of actin cytoskeleton
hsa04912
GnRH signaling pathway
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05100
Bacterial invasion of epithelial cells
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05135
Yersinia infection
hsa05165
Human papillomavirus infection
hsa05200
Pathways in cancer
hsa05203
Viral carcinogenesis
hsa05205
Proteoglycans in cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05417
Lipid and atherosclerosis
Network
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06521
NLR signaling
Element
N01070
ITGA/B-FAK-CDC42 signaling pathway
N01071
Shigella IpgB1 to ITGA/B-FAK-CDC42 signaling pathway
N01076
Shigella IcsB to ITGA/B-FAK-CDC42 signaling pathway
N01096
Escherichia Map to CDC42 signaling pathway
N01112
Salmonella SopE/E2 to NOD-NFKB signaling pathway
N01119
RAC/CDC42-PAK-ERK signaling pathway
N01120
Salmonella SptP to RAC/CDC42-PAK-ERK signaling pathway
N01134
Salmonella SopB to CDC42 signaling pathway
Disease
H02667
Takenouchi-Kosaki syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
998 (CDC42)
04014 Ras signaling pathway
998 (CDC42)
04015 Rap1 signaling pathway
998 (CDC42)
04370 VEGF signaling pathway
998 (CDC42)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
998 (CDC42)
09144 Cellular community - eukaryotes
04510 Focal adhesion
998 (CDC42)
04520 Adherens junction
998 (CDC42)
04530 Tight junction
998 (CDC42)
09142 Cell motility
04810 Regulation of actin cytoskeleton
998 (CDC42)
09150 Organismal Systems
09151 Immune system
04660 T cell receptor signaling pathway
998 (CDC42)
04666 Fc gamma R-mediated phagocytosis
998 (CDC42)
04670 Leukocyte transendothelial migration
998 (CDC42)
04062 Chemokine signaling pathway
998 (CDC42)
09152 Endocrine system
04912 GnRH signaling pathway
998 (CDC42)
09156 Nervous system
04722 Neurotrophin signaling pathway
998 (CDC42)
09158 Development and regeneration
04360 Axon guidance
998 (CDC42)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
998 (CDC42)
05205 Proteoglycans in cancer
998 (CDC42)
05203 Viral carcinogenesis
998 (CDC42)
09162 Cancer: specific types
05212 Pancreatic cancer
998 (CDC42)
05211 Renal cell carcinoma
998 (CDC42)
09172 Infectious disease: viral
05165 Human papillomavirus infection
998 (CDC42)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
998 (CDC42)
05130 Pathogenic Escherichia coli infection
998 (CDC42)
05132 Salmonella infection
998 (CDC42)
05131 Shigellosis
998 (CDC42)
05135 Yersinia infection
998 (CDC42)
05100 Bacterial invasion of epithelial cells
998 (CDC42)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
998 (CDC42)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
998 (CDC42)
04933 AGE-RAGE signaling pathway in diabetic complications
998 (CDC42)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
998 (CDC42)
03036 Chromosome and associated proteins [BR:
hsa03036
]
998 (CDC42)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
998 (CDC42)
04031 GTP-binding proteins [BR:
hsa04031
]
998 (CDC42)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Small GTPases and associated proteins
Rho GTPases
998 (CDC42)
Endocytosis
Lipid raft mediated endocytosis
GRAF1-dependent endocytosis
998 (CDC42)
Macropinocytosis
Ras GTPases
998 (CDC42)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation proteins
Other centriole associated proteins
998 (CDC42)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of microglial cells
998 (CDC42)
Exosomal proteins of breast milk
998 (CDC42)
GTP-binding proteins [BR:
hsa04031
]
Small (monomeric) G-proteins
Rho Family
Rac/Cdc42 [OT]
998 (CDC42)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ras
Roc
Arf
GTP_EFTU
Motif
Other DBs
NCBI-GeneID:
998
NCBI-ProteinID:
NP_001034891
OMIM:
116952
HGNC:
1736
Ensembl:
ENSG00000070831
UniProt:
P60953
Structure
PDB
LinkDB
All DBs
Position
1:22052709..22101360
Genome browser
AA seq
191 aa
AA seq
DB search
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP
EPKKSRRCVLL
NT seq
576 nt
NT seq
+upstream
nt +downstream
nt
atgcagacaattaagtgtgttgttgtgggcgatggtgctgttggtaaaacatgtctcctg
atatcctacacaacaaacaaatttccatcggaatatgtaccgactgtttttgacaactat
gcagtcacagttatgattggtggagaaccatatactcttggactttttgatactgcaggg
caagaggattatgacagattacgaccgctgagttatccacaaacagatgtatttctagtc
tgtttttcagtggtctctccatcttcatttgaaaacgtgaaagaaaagtgggtgcctgag
ataactcaccactgtccaaagactcctttcttgcttgttgggactcaaattgatctcaga
gatgacccctctactattgagaaacttgccaagaacaaacagaagcctatcactccagag
actgctgaaaagctggcccgtgacctgaaggctgtcaagtatgtggagtgttctgcactt
acacagaaaggcctaaagaatgtatttgacgaagcaatattggctgccctggagcctcca
gaaccgaagaagagccgcaggtgtgtgctgctatga
DBGET
integrated database retrieval system