Homo sapiens (human): 8325
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Entry
8325 CDS
T01001
Symbol
FZD8, FZ-8, hFZ8
Name
(RefSeq) frizzled class receptor 8
KO
K02375
frizzled 5/8
Organism
hsa
Homo sapiens (human)
Pathway
hsa04150
mTOR signaling pathway
hsa04310
Wnt signaling pathway
hsa04390
Hippo signaling pathway
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04916
Melanogenesis
hsa04934
Cushing syndrome
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05165
Human papillomavirus infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05217
Basal cell carcinoma
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
Network
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181
Salmonella
nt06215
WNT signaling (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06274
Thyroid cancer
nt06505
WNT signaling
Element
N00056
Wnt signaling pathway
N00060
LRP6-overexpression to Wnt signaling pathway
N01427
WNT5A-ROR signaling pathway
N01440
Wnt signaling modulation, LGR/RSPO
N01441
Wnt signaling modulation, SOST/LRP4
Drug target
Ipafricept:
D11758
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
8325 (FZD8)
04390 Hippo signaling pathway
8325 (FZD8)
04150 mTOR signaling pathway
8325 (FZD8)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
8325 (FZD8)
09150 Organismal Systems
09152 Endocrine system
04916 Melanogenesis
8325 (FZD8)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
8325 (FZD8)
05205 Proteoglycans in cancer
8325 (FZD8)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
8325 (FZD8)
05226 Gastric cancer
8325 (FZD8)
05217 Basal cell carcinoma
8325 (FZD8)
05224 Breast cancer
8325 (FZD8)
09172 Infectious disease: viral
05165 Human papillomavirus infection
8325 (FZD8)
09164 Neurodegenerative disease
05010 Alzheimer disease
8325 (FZD8)
05022 Pathways of neurodegeneration - multiple diseases
8325 (FZD8)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
8325 (FZD8)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
8325 (FZD8)
G protein-coupled receptors [BR:
hsa04030
]
Frizzled / Smoothened family
8325 (FZD8)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Frizzled
Fz
PhaG_MnhG_YufB
Motif
Other DBs
NCBI-GeneID:
8325
NCBI-ProteinID:
NP_114072
OMIM:
606146
HGNC:
4046
Ensembl:
ENSG00000177283
UniProt:
Q9H461
Structure
PDB
LinkDB
All DBs
Position
10:complement(35638247..35642296)
Genome browser
AA seq
694 aa
AA seq
DB search
MEWGYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHD
TQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAP
LMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGS
GHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVS
VSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFL
IDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGA
GAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLT
WFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDN
LRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLY
TVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITS
GVWVWSGKTLESWRSLCTRCCWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGG
GGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
NT seq
2085 nt
NT seq
+upstream
nt +downstream
nt
atggagtggggttacctgttggaagtgacctcgctgctggccgccttggcgctgctgcag
cgctctagcggcgctgcggccgcctcggccaaggagctggcatgccaagagatcaccgtg
ccgctgtgtaagggcatcggctacaactacacctacatgcccaatcagttcaaccacgac
acgcaagacgaggcgggcctggaggtgcaccagttctggccgctggtggagatccagtgc
tcgcccgatctcaagttcttcctgtgcagcatgtacacgcccatctgcctagaggactac
aagaagccgctgccgccctgccgctcggtgtgcgagcgcgccaaggccggctgcgcgccg
ctcatgcgccagtacggcttcgcctggcccgaccgcatgcgctgcgaccggctgcccgag
caaggcaaccctgacacgctgtgcatggactacaaccgcaccgacctaaccaccgccgcg
cccagcccgccgcgccgcctgccgccgccgccgcccggcgagcagccgccttcgggcagc
ggccacggccgcccgccgggggccaggcccccgcaccgcggcggcggcaggggcggtggc
ggcggggacgcggcggcgcccccagctcgcggcggcggcggtggcgggaaggcgcggccc
cctggcggcggcgcggctccctgcgagcccgggtgccagtgccgcgcgcctatggtgagc
gtgtccagcgagcgccacccgctctacaaccgcgtcaagacaggccagatcgctaactgc
gcgctgccctgccacaacccctttttcagccaggacgagcgcgccttcaccgtcttctgg
atcggcctgtggtcggtgctctgcttcgtgtccaccttcgccaccgtctccaccttcctt
atcgacatggagcgcttcaagtacccggagcggcccattatcttcctctcggcctgctac
ctcttcgtgtcggtgggctacctagtgcgcctggtggcgggccacgagaaggtggcgtgc
agcggtggcgcgccgggcgcggggggcgctgggggcgcgggcggcgcggcggcgggcgcg
ggcgcggcgggcgcgggcgcgggcggcccgggcgggcgcggcgagtacgaggagctgggc
gcggtggagcagcacgtgcgctacgagaccaccggccccgcgctgtgcaccgtggtcttc
ttgctggtctacttcttcggcatggccagctccatctggtgggtgatcttgtcgctcaca
tggttcctggcggccggtatgaagtggggcaacgaagccatcgccggctactcgcagtac
ttccacctggccgcgtggcttgtgcccagcgtcaagtccatcgcggtgctggcgctcagc
tcggtggacggcgacccggtggcgggcatctgctacgtgggcaaccagagcctggacaac
ctgcgcggcttcgtgctggcgccgctggtcatctacctcttcatcggcaccatgttcctg
ctggccggcttcgtgtccctcttccgcatccgctcggtcatcaagcaacaggacggcccc
accaagacgcacaagctggagaagctgatgatccgcctgggcctgttcaccgtgctctac
accgtgcccgccgcggtggtggtcgcctgcctcttctacgagcagcacaaccgcccgcgc
tgggaggccacgcacaactgcccgtgcctgcgggacctgcagcccgaccaggcacgcagg
cccgactacgccgtcttcatgctcaagtacttcatgtgcctagtggtgggcatcacctcg
ggcgtgtgggtctggtccggcaagacgctggagtcctggcgctccctgtgcacccgctgc
tgctgggccagcaagggcgccgcggtgggcgggggcgcgggcgccacggccgcggggggt
ggcggcgggccggggggcggcggcggcgggggacccggcggcggcggggggccgggcggc
ggcgggggctccctctacagcgacgtcagcactggcctgacgtggcggtcgggcacggcg
agctccgtgtcttatccaaagcagatgccattgtcccaggtctga
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