KEGG   Klebsiella pneumoniae subsp. pneumoniae KPNIH30: KPNIH30_26920
Entry
KPNIH30_26920     CDS       T03466                                 
Name
(GenBank) dihydrofolate reductase
  KO
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Organism
kpw  Klebsiella pneumoniae subsp. pneumoniae KPNIH30
Pathway
kpw00670  One carbon pool by folate
kpw00790  Folate biosynthesis
kpw01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:kpw00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    KPNIH30_26920
   00670 One carbon pool by folate
    KPNIH30_26920
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes [BR:kpw01504]
    KPNIH30_26920
Enzymes [BR:kpw01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     KPNIH30_26920
Antimicrobial resistance genes [BR:kpw01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    KPNIH30_26920
SSDB
Motif
Pfam: DHFR_1
Other DBs
NCBI-ProteinID: AIX81930
UniProt: S5LSU8
LinkDB
Position
pKPN-b9c:9625..10098
AA seq 157 aa
MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI
EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG
NT seq 474 nt   +upstreamnt  +downstreamnt
gtgaaactatcactaatggtagctatatcgaagaatggagttatcgggaatggccctgat
attccatggagtgccaaaggtgaacagctcctgtttaaagctattacctataaccaatgg
ctgttggttggacgcaagacttttgaatcaatgggagcattacccaaccgaaagtatgcg
gtcgtaacacgttcaagttttacatctgacaatgagaacgtattgatctttccatcaatt
aaagatgctttaaccaacctaaagaaaataacggatcatgtcattgtttcaggtggtggg
gagatatacaaaagcctgatcgatcaagtagatacactacatatatctacaatagacatc
gagccggaaggtgatgtttactttcctgaaatccccagcaattttaggccagtttttacc
caagacttcgcctctaacataaattatagttaccaaatctggcaaaagggttaa

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