Loxodonta africana (African savanna elephant): 100661109
Help
Entry
100661109 CDS
T04351
Symbol
DOT1L
Name
(RefSeq) LOW QUALITY PROTEIN: histone-lysine N-methyltransferase, H3 lysine-79 specific
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
lav
Loxodonta africana (African savanna elephant)
Pathway
lav00310
Lysine degradation
lav01100
Metabolic pathways
lav05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
lav00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
100661109 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
100661109 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
lav03036
]
100661109 (DOT1L)
Enzymes [BR:
lav01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
100661109 (DOT1L)
Chromosome and associated proteins [BR:
lav03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
100661109 (DOT1L)
HMT complexes
Dot1-containing complex
100661109 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
100661109
NCBI-ProteinID:
XP_023397032
LinkDB
All DBs
Position
Unknown
AA seq
1774 aa
AA seq
DB search
MALPYKGEQQALRLPLGRVPRNHPALKLFPFVFQDKHHDAAHEIIETIRWVCEEIPDLKL
AMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPCNGLLRHILQQ
VYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQV
AAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIA
NTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRV
VELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNT
TTPTKVQESKAAVPADTPMDSGAEDEKAGATTVKKPSPSKARKKKLNKKGRKMAGRKRGR
PKKMSTANPERRPRKSQTTLDLLHTQAAPQTAPSSPQDAYKSPHSPFYQLPPAVQRHASS
PLLAAPTPPALQKLLESFKIQYLQFLAYTKTPQYKANLQLLLDQEKDQYKAASCEAEVED
VQMSTFSIISDVSLSPSHWPQHLTGRAYLELGGLLGEITPWIGVQCWGLSSALYCSVGSS
HPLPTTSVPWGGCQTRDSLQHLYPPPRQLKARCEELKLDWPTLSLEKLLKEKQALKSQIS
EKQRRCLELQISIVELEKSQRQQELLQLKSSVPADDALAVHLRGKGVLSREPEPDPGRLH
LELDCAKFSLPPFSSLSPELSMNGHAAGYELYSTLSRPASKQNTPQYLASALDQEVVPCT
PSHGGRPRLDKLASLALPDYTRLSPAKIVLRRHLSQDPAANGKVATSELHPRAEHAKENG
LTRQSPGISSSITLSPQDPQPVSPVALQMTGEKGSEKGLKERPYGSSSETITSLPVSIPL
STVQPNKLPVSIPLASVVLPSRAERVRSTPSPVHQSRDPSSTLDKQIGANPHSGASSAAG
SRGLALAPAGFSYAGSVAITGALAGSPAALAPGAEPATLDESSGSGSLLAALGSRSSTPQ
HPTLLAQARSSGPASPAHQLSASPRLGGPSQGTLSDAAGKSDLPCDAGFSDPESEAKRRI
VFTIAAGSGGARPSPSSKHSPLATSARGDGGQGHGQDSRKRGRRKRSSAGTPSLSSGVSP
KRRAPPSVAGLFTQSSGSPLNLNSMVNNINQPLEITAISSPESSLKSSPVPYQDHDQPPV
LKKEKPLGQTNGAHYSPLTSDDEQGSEDEPGSARIERKIATISLESKSPPKTLENGGGLA
SRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSVLSQNSVFAFRPTLEESGAT
DAKGAAHPRKGFSGSLAGADGPSLNTNPPNGFALSGALAADLSLHSFSDGASLAHKAPEA
AGLSFPPQRGKEAGAPEANPFLSKRPLDGLGGLKGEASKAREAGDLGPALGSASEKAALP
PIGKAGRGRDRELDFTHGHNLFISAAAVPPGGLLSGPGLAPAVSSTGTHAPSTQTHRPFM
GNFAPGAQFALGPMSLQANLGSVAGSSVLQSLFSAVPAAAGLVHVSSAATRLTNSHAMGT
FSSGVAGGTVGGRRGAFLCRRLVASTWPWGSSGRRGAVCGSATLSLAPLHAVASTSAASF
QAPSSVETRPPPLPPAQHLGRPPPPPPPLPVQPGLPPPPPNTALPPPPPLLAPNSEPVLL
QSLASLPANHAFLPPASAASLPPANASLSVKLAALPHKASRPSFTVHRPPLPRLALAQAA
PLLPQASPAAPSAVWVSLGMPSPYAAHLSGVKPR
NT seq
5325 nt
NT seq
+upstream
nt +downstream
nt
atggcattgccatacaagggggagcagcaggctctccgactgcctctgggccgtgtaccc
cgcaaccacccggctctaaaactgtttccgtttgtttttcaggacaaacatcacgatgct
gctcacgaaatcatcgagaccatccgatgggtctgtgaagaaatcccagatctcaagctt
gccatggaaaactatgttttaattgactatgataccaaaagcttcgagagcatgcagagg
ctctgtgacaagtacaaccgggccatcgacagcatccaccagctgtggaaggggaccacg
cagcccatgaagctgaacacgcggccgtgcaatgggctcctgcggcacatcctgcagcag
gtctacaaccactcggtgaccgaccccgagaagctcaacaactacgagcccttctcgccc
gaggtgtacggcgagacctccttcgacctggtggcacagatgatcgacgagatcaagatg
accgaggacgacctgtttgtggacctgggcagcggagtgggccaggttgtgctccaggtc
gctgcagccaccaactgcaaacatcactacggcgtggagaaagctgacatcccagccaag
tacgcggagacgatggacagagagttcaggaagtggatgaaatggtatggaaaaaagcat
gccgaatacacactggaaagaggcgatttcctctcagaagagtggcgtgagcggattgcg
aacacgagtgttatatttgtgaataactttgcctttggtcctgaggtggatcaccagctg
aaggagcgatttgcaaacatgaaggaaggtggcagaatcgtgtcctcaaaaccctttgca
cctctaaacttcagaataaacagtagaaacttgagcgatatcggcaccatcatgcgcgtc
gtggagctgtcgcccctgaagggctcagtctcgtggacggggaagccggtctcctactac
ctgcacactatcgaccgaaccatacttgaaaactatttttctagtctgaaaaatccaaaa
ctcagggaggaacaagaggcagctaggcgtcggcagcaacgcgaaaacaagagcaacacg
accactccaaccaaggtccaggagagcaaggcggccgtccctgcggacacccccatggac
tctggtgctgaggacgagaaagccggggccaccactgtcaaaaagccatccccctcgaaa
gcccgcaagaagaagctgaacaagaagggccggaagatggccggccggaagcgtgggcgt
cccaagaagatgagcactgcgaaccccgagcgcaggcccaggaagagccaaaccacactg
gacctcctgcacacgcaggctgcgccccagaccgccccgtcctcgcctcaggatgcgtac
aagtcacctcacagcccgttctaccagctacctccggccgtgcagcggcacgcgtccagc
ccgctgctggcggcgcccaccccgcccgcgctacagaagctgctagagtctttcaagatc
cagtacctgcagttcttggcatacaccaagaccccgcagtacaaggccaacctgcagctg
ctgctggaccaggagaaggatcagtacaaagctgcttcctgcgaggcggaagttgaagat
gtccaaatgtccaccttctccatcatctctgacgtcagcctctccccctcgcattggcca
cagcatctcacaggacgcgcgtacttagagttaggtggtttactgggggagataaccccc
tggatcggagtgcagtgctgggggctgtcctctgcgctgtactgcagcgtgggctcctcc
catcctctcccaaccacgagtgtgccctggggagggtgccagaccagggactcactgcag
cacttgtaccccccgccccggcagcttaaggcacggtgtgaggagctgaagctggactgg
cccaccctgtccctggagaagctgctgaaggagaagcaggccctgaagagccagatctct
gagaaacagaggcgctgcctggagctgcagatcagcatcgtggagctggagaagagccag
cggcagcaggagctgctacagctcaagtcctccgtgccagcggacgacgccctggctgtg
cacctgcgcgggaaaggcgtgctgagccgggagccagagcctgaccctggccgcctccac
ctggagctcgactgtgccaagttctcgctgccgcccttcagcagcctgagcccggagctc
tccatgaacggccacgcggccggctacgagctgtacagcacgctcagccgacccgcgtcc
aagcagaacaccccacagtacctggcctcagccctggaccaggaggtggtgccctgtaca
cccagccatgggggccggccgcggctggacaagctggccagcctggccctgcccgactac
actcggctctctccagccaagatcgtactgaggcgtcacctgagccaggaccccgcggcc
aacggaaaggtggccaccagtgagctgcacccacgtgcggagcatgccaaggagaacggc
ctcacccgtcagagccccggcatctccagcagcatcacattgagtccgcaagaccctcag
cctgtgtcccccgtggccttacagatgacaggggagaagggcagtgagaagggcttgaag
gagcgcccctatggcagcagtagtgagaccatcaccagcctgcctgtcagcatcccgctc
agcaccgtgcagcccaacaagctcccagtcagcatccctctggccagcgtggtgttgccc
agccgtgcagagcgagtgaggagcacgccaagccccgtgcaccagagccgagacccctcc
tctacgctcgacaagcagatcggtgctaaccctcacagcggtgcgagcagtgctgccgga
agtagaggcctggccctggcccccgcaggcttctcctatgccggctcggtggccatcact
ggggccctggcgggcagcccggcagccctcgcccccggggctgagccagccaccttggac
gaatcctcgggctcaggcagcctccttgctgccctgggctcacgcagctccacaccgcag
caccccaccctactggcgcaggcccgcagctctggcccggcctctcccgcccatcagctc
tcagccagcccccggcttgggggaccttcccagggcacactctccgatgctgctggcaag
agcgacctgccctgcgatgcaggcttctcagaccctgagagcgaggccaagcgcaggatt
gttttcaccattgcagccggctcagggggtgcacggccatccccctccagcaagcacagc
cccctggccaccagcgcccgtggggacggtgggcagggccacgggcaggacagccgaaag
cgaggccgcaggaagcgctcatcggcaggcacccccagcctgagctcaggagtgtccccc
aagcgccgggccccaccatctgttgctggactcttcacacagtcctcggggtcccccctg
aacctcaactccatggtcaacaacatcaaccagcccctggagatcacggccatctcgtcc
cctgagagctccctgaagagctcgccggtcccctaccaggaccatgaccagccgcccgtg
ctcaagaaggagaagccgctgggccaaaccaatggggcacactactcgccgctgacgtcg
gacgacgagcagggctccgaggatgagcccggcagcgccagaatcgagaggaaaattgca
acaatatccttagaaagcaaatctcccccaaaaaccttagaaaatggtggtggcctggcc
agcaggaagccggcaccggccggtgagccagtcaacagcagcaagtggaagtccacattc
tcgcccatctcggacattggcctagccaagtcggccgacagcccgctgcaggccagctcc
gtgctgagccagaactccgtgtttgcgtttcggcccaccctggaggagtctggcgccacc
gatgccaagggggctgcacaccccaggaagggcttctcgggctccctggcaggggcggat
gggcccagcctgaacaccaacccccccaacgggttcgccctcagcggggccctggccgcc
gaccttagtttacacagcttcagcgatggtgcttctcttgcccacaaggcccctgaggca
gctgggctgagcttcccccctcagcggggcaaggaggctggcgccccagaggccaacccc
ttcctgagcaagcggccactggatggactgggtggcttgaagggcgaggccagcaaggcc
cgcgaggccggcgacctgggcccggccttaggcagtgcctctgagaaggctgccctgccg
cccatcgggaaggcaggccgaggccgggaccgcgagcttgacttcacccacggccataac
ctcttcatctcggctgctgctgtgccccctgggggcctcctcagcggcccgggcctggcc
ccggcagtgtcctccacgggcacccatgccccctccactcagacgcatcgccccttcatg
ggcaacttcgcccccggtgcacagttcgccctgggccccatgtccctgcaggctaacctg
ggctcagtggcaggctcatctgtgctgcagtccctgttcagtgccgtgccggccgctgca
ggcctggtgcacgtgtcatctgcggccaccaggctcaccaactcgcatgccatgggcacc
ttctcttccggagtcgcgggcggaactgtcggaggtaggcgaggcgcgtttctttgccgg
cgtcttgttgccagcacctggccttggggctcctcaggcaggcgcggggctgtctgtggc
agcgccacgctgagcttagccccgctgcatgcggtggccagcacctccgccgcttccttt
caggccccgtcctctgttgagacccggccgcccccgctgcctcctgctcagcacctgggc
cggcctcccccaccacctcctcctcttccggtgcagcctggcctcccaccccctccgcct
aacaccgccttgcctcctcccccaccgctgctggcacctaactccgagcccgtgctcctg
cagagcctggcgtccctccctgctaaccatgctttcttgccccccgcctctgctgcctcc
ctgccgcccgctaacgcctctttgtctgtcaagcttgctgccctgccacacaaggcttcc
cgcccctccttcacggtccaccgcccgcctctgccccggctggccctggcgcaggctgcg
cccctcctcccgcaggccagccccgccgcaccctccgcggtctgggtttcccttggcatg
ccgtctccttatgccgcgcacctttcgggggttaagccgcgataa
DBGET
integrated database retrieval system
