Lutra lutra (Eurasian river otter): 125085453 Help Entry 125085453         CDS       T08100                                  Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism llv  Lutra lutra (Eurasian river otter) Pathway llv04010   MAPK signaling pathway llv04014   Ras signaling pathway llv04015   Rap1 signaling pathway llv04022   cGMP-PKG signaling pathway llv04066   HIF-1 signaling pathway llv04068   FoxO signaling pathway llv04072   Phospholipase D signaling pathway llv04150   mTOR signaling pathway llv04151   PI3K-Akt signaling pathway llv04152   AMPK signaling pathway llv04211   Longevity regulating pathway llv04213   Longevity regulating pathway - multiple species llv04520   Adherens junction llv04910   Insulin signaling pathway llv04913   Ovarian steroidogenesis llv04923   Regulation of lipolysis in adipocytes llv04930   Type II diabetes mellitus llv04931   Insulin resistance llv04932   Non-alcoholic fatty liver disease llv04960   Aldosterone-regulated sodium reabsorption llv05010   Alzheimer disease llv05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:llv00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     125085453    04014 Ras signaling pathway     125085453    04015 Rap1 signaling pathway     125085453    04066 HIF-1 signaling pathway     125085453    04068 FoxO signaling pathway     125085453    04072 Phospholipase D signaling pathway     125085453    04022 cGMP-PKG signaling pathway     125085453    04151 PI3K-Akt signaling pathway     125085453    04152 AMPK signaling pathway     125085453    04150 mTOR signaling pathway     125085453  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     125085453  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     125085453    04923 Regulation of lipolysis in adipocytes     125085453    04913 Ovarian steroidogenesis     125085453   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     125085453   09149 Aging    04211 Longevity regulating pathway     125085453    04213 Longevity regulating pathway - multiple species     125085453  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     125085453   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     125085453   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     125085453    04932 Non-alcoholic fatty liver disease     125085453    04931 Insulin resistance     125085453  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:llv01001]     125085453   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:llv04090]     125085453 Enzymes [BR:llv01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      125085453 Protein kinases [BR:llv01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    125085453 CD molecules [BR:llv04090]  Proteins   125085453 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  125085453 NCBI-ProteinID:  XP_047559754 LinkDB All DBs Position 1:complement(217338975..217464527) Genome browser AA seq 1381 aa AA seqDB search MGAGAGRGAATAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTSCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTSEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKSARRQG CHQYVIHSNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC TVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKLQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFEAEGSPKHNQSEHEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRKSSSSPGAEDTRPSRKRRALRDVANVTAAVPTAPGF PNTSTSTPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDAPEERCSVAAYVS ARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVS RRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGP LIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPRE KITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAA EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC PERVTDLMRMCWQFNPKMRPSFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEF EDMESVPLDRASHSQREEAGGRDGGSSLGLKRNYEEHIPYTHMNGGKKNGRILTLPRSNP S NT seq 4146 nt NT seq  +upstreamnt  +downstreamnt atgggcgccggggctgggcggggggcggcgaccgcgccgctgctggtggcggtggccgcg ctgctgctgggtgccgcgggccacctgtaccccggagaggtgtgtcccggcatggatatc cggaacaacctcacgaggttgcatgagctggccaactgctcggtcattgaaggacatttg cagatactgttgatgttcaaaacgaggcccgaggatttccgagacctcagtttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacctgttccccaacctcacggtcatccggggctcgcgcctcttcttcaactacgcactg gtcatcttcgagatggttcacctgaaggaactcggcctctatagcttgatgaacattacc cggggctccgtccgcatcgagaaaaataacgagctgtgctacctggccaccatcgactgg tcgcgcatcctggattctgtggaggataattacattgtgctgaacaaagacgacaacgag gagtgtggggacatttgtccaggcacggcgaagggcaagaccagctgccctgccactgtc atcaacgggcagtttgtcgagcggtgttggacacacagccactgccagaaagtttgtccc accatctgcaagtcgcacggctgcacctcggagggcctctgctgccacagcgagtgctta ggcaattgctctgagcccgacgaccccaccaagtgcgtggcctgtcgcaacttctacctg gatggcaggtgcgtggagacctgcccgcccccctactaccacttccaggactggcgctgc gtgaacttcagcttttgccaggacctacacaacaagtgcaagagcgcccggaggcagggc tgccaccagtacgtcattcacagcaacaagtgcatccccgagtgcccctctggttacacg atgaattccagcaacctgatgtgcactccatgcctgggtccctgtcccaaggtctgccac atcctggaaggcgagaagaccattgactcggtgacgtccgcccaggagcttcgaggctgc actgtggtcaacggaagcctcatcatcaacatccgagggggcaacaacctggcagctgag ctggaggccaaccttggactcattgaggaaatttccgggtatctgaagatccggagatcc tacgctcttgtatcactttcctttttccggaagttacggctgattcgaggagagaccttg gaaatcgggaactactctttctacgccttggacaaccagaacctaaggcagctttgggat tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataatcccaaa ctctgcttgtcagaaattcataagatggaggaagtttcgggaaccaaggggcgccaggag aggaacgacattgccctgaagaccaacggggaccaggcgtcttgtgagaatgaactcctt aaattttcttacattcggacatcatacgacaagatcttgctgaaatgggagccatactgg ccccctgacttccgagacctcctggggttcatgcttttctacaaagaggccccttaccag aatgtgaccgagttcgacgggcaggatgcgtgtggctccaacagctggaccgtggtggac attgacccccctctgcggtccaatgaccccaagttgcagaaccacccagggtggctgatg cggggtctcaagccctggacccagtatgccatctttgtcaagaccttggttaccttttct gatgaacgccgcacatatggggccaagagtgacatcatctatgtgcagacagatgctact aacccttccgtccccctggatccaatctccgtttctaattcctcgtcccagattatcctg aagtggaaacctccctcggaccccaacggcaacatcacacactacctggttttctgggag aggcaggcggaagacagtgagctgtacgagctggattattgcctcaaagggttgaagctg ccatcccggacctggtctccgccattcgaggctgagggctccccgaagcacaaccagagt gaacacgaggagtccgccggcgagtgctgctcctgccccaagacagactcccagatcctc aaggagctggaggagtcctcttttaggaagacctttgaggattacctgcacaatgtggtg ttcgtccccagaaaatcctcgtcaagccctggtgctgaggacactaggccatcgcggaaa cgcagggccctcagggacgttgccaacgtgacagcggccgtgcccacagctccaggtttc cccaacacctcgactagcacgcccacaagcccggaggagcacaagccttttgagaaagtg gtgaacaaggagtccctggtcatctctgggctgcgtcatttcaccggctaccgtatcgag ctgcaggcttgcaaccaggacgcccccgaggagaggtgcagcgtggcggcctacgtcagc gccaggaccatgcccgaagccaaggcagacgacatcgttggccctgtgacccacgaaatc ttcgagaacaatgtcgttcacttgatgtggcaggagccgaaggaacccaacggtctgatt gtgctgtatgaagtgagttaccgacgctatggtgatgaggagctgcacctctgtgtctcc cgcagacacttcgctctggagcggggctgcaggctgcgcgggctaccgccggggaattac agcgtgcgagtccgggctacctccctggcaggcaacggctcctggacagaagccacctat ttctacgtgacagactatttagatgtcccatcaaatattgcaaaaatcatcatcggcccc ctgatctttgtctttctcttcagtgttgtgattggaagtatttacctgttcctgcggaag aggcagccggatgggccactgggaccgctgtatgcatcttcaaaccctgagtacctcagt gccagtgatgtgtttccatgttctgtgtatgtgccggacgagtgggaggtgcctcgggag aagatcactctcctgcgcgagctggggcagggctccttcggcatggtgtacgagggcaac gccagggacatcgtcaagggcgaggcggagacccgtgtggcggtgaagacggtcaacgag tcggccagtctgcgggagaggatcgagtttctcaacgaggcctcagtcatgaagggcttc acctgtcatcacgtggtccgcctcctgggggtggtgtccaaaggccagccgacgctggtg gtgatggagctgatggcccacggagacctcaagagctacctccgctccctgcggccggag gctgagaataaccccggccgccctccccctaccctgcaagagatgattcagatggcggcg gagatcgccgatgggatggcctacctgaatgccaagaagttcgtgcaccgggatcttgca gcccgcaactgcatggtggcccacgatttcaccgtcaaaattggagactttgggatgacc agagacatctatgaaacggattactaccggaaaggaggcaagggtctgctccctgtgcgg tggatggcaccggaatccctgaaggacggggtctttaccacttcttctgacatgtggtcc tttggcgtggtcctttgggaaatcaccagcttggcagaacagccttaccaaggcctgtca aatgaacaggtgttgaaatttgtcatggatggagggtatctggaccaacccgacaattgt ccagagagagtcaccgacctgatgcgtatgtgctggcaattcaatcccaagatgcggccc tccttcctggagatcgtcgacctgctcaaggatgacctgcaccccagctttccggaagtt tccttcttccacagcgaggagaacaaggcacctgagagcgaggagctggagatggagttt gaggacatggagagtgtccccctggatcgggcctcccactctcagagggaggaggccggg ggccgggatggagggtcctccctgggcctaaagcggaactacgaggagcacatcccctat acccacatgaatgggggcaagaaaaacggacggattctgactctgcccaggtcgaatcct tcctaa

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