Leptonychotes weddellii (Weddell seal): 102730888 Help Entry 102730888         CDS       T08708                                  Symbol INSR Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism lww  Leptonychotes weddellii (Weddell seal) Pathway lww04010   MAPK signaling pathway lww04014   Ras signaling pathway lww04015   Rap1 signaling pathway lww04022   cGMP-PKG signaling pathway lww04066   HIF-1 signaling pathway lww04068   FoxO signaling pathway lww04072   Phospholipase D signaling pathway lww04150   mTOR signaling pathway lww04151   PI3K-Akt signaling pathway lww04152   AMPK signaling pathway lww04211   Longevity regulating pathway lww04213   Longevity regulating pathway - multiple species lww04520   Adherens junction lww04910   Insulin signaling pathway lww04913   Ovarian steroidogenesis lww04923   Regulation of lipolysis in adipocytes lww04930   Type II diabetes mellitus lww04931   Insulin resistance lww04932   Non-alcoholic fatty liver disease lww04960   Aldosterone-regulated sodium reabsorption lww05010   Alzheimer disease lww05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:lww00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     102730888 (INSR)    04014 Ras signaling pathway     102730888 (INSR)    04015 Rap1 signaling pathway     102730888 (INSR)    04066 HIF-1 signaling pathway     102730888 (INSR)    04068 FoxO signaling pathway     102730888 (INSR)    04072 Phospholipase D signaling pathway     102730888 (INSR)    04022 cGMP-PKG signaling pathway     102730888 (INSR)    04151 PI3K-Akt signaling pathway     102730888 (INSR)    04152 AMPK signaling pathway     102730888 (INSR)    04150 mTOR signaling pathway     102730888 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     102730888 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     102730888 (INSR)    04923 Regulation of lipolysis in adipocytes     102730888 (INSR)    04913 Ovarian steroidogenesis     102730888 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     102730888 (INSR)   09149 Aging    04211 Longevity regulating pathway     102730888 (INSR)    04213 Longevity regulating pathway - multiple species     102730888 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102730888 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     102730888 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     102730888 (INSR)    04932 Non-alcoholic fatty liver disease     102730888 (INSR)    04931 Insulin resistance     102730888 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:lww01001]     102730888 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:lww04090]     102730888 (INSR) Enzymes [BR:lww01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      102730888 (INSR) Protein kinases [BR:lww01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    102730888 (INSR) CD molecules [BR:lww04090]  Proteins   102730888 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Furin-like Recep_L_domain Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  102730888 NCBI-ProteinID:  XP_030893766 UniProt:  A0A7F8RKL8 LinkDB All DBs Position Unknown AA seq 1137 aa AA seqDB search MGTGAGRGAATAPLLLAVAALLLGATGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHGQCL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNRCKNSRRQG CHQYVIHNSKCIPECPSGYTMNSSKESQGPLKLCAGTWDCHHRGHSEELDMPRVCNQPRQ SLPPAHGAPVFPFSFADPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQVE DSELYELDYCLKGLKLPSRTWSPPFEAEGSQKHNQSEYEESAGECCSCPKTDSQILKELE ESSFRKTFEDYLHNVVFVPRKSSSSPGAEDTRPSRKRRALRDVANVTAAAPTVPGFPNTS TSAPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYVSARTM PEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRRHF ALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGPLIFV FLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKITL LRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHH VVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIAD GMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAP ESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERV TDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDME SVPLDRASHSQREEAGGRDGGSSLGLKRNYEEHIPYTHMNGGKKNGRILTLPRSNPS NT seq 3414 nt NT seq  +upstreamnt  +downstreamnt atgggcaccggggctgggcggggggcggcgaccgcgccgctgctgctggcggtggccgcg ctgctgctgggtgccacgggccacctgtaccccggagaggtgtgccctggcatggatatc cggaacaacctcacgcggttgcatgagctggccaactgctcggtcattgaaggacatctg cagatactgctgatgttcaaaacgaggcccgaggatttccgagacctcagcttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacctgttccccaacctcacggtcatccggggctcacgtctcttcttcaactatgcactg gtcatcttcgagatggtgcacctgaaggagcttggcctctacagcttgatgaacattacc cggggctccgtccgcattgagaagaacaatgagctctgctacctggccaccatcgactgg tcgcgcatcctggattccgtggaggataattacattgtgctgaacaaagatgacaacgag gagtgtggggacatttgtccaggcaccgcaaagggaaagaccaactgccctgccactgtc atcaacgggcagtttgtcgagcggtgttggactcacagccactgtcagaaagtttgtccc accatctgcaagtcacacggctgcaccgccgagggtctctgctgccacggccagtgtttg ggcaattgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaacttctacctg gatggcaggtgcgtggagacctgcccgcccccatactaccacttccaagactggcgctgt gtgaacttcagcttctgccaggacctgcacaacagatgcaagaactcccggagacagggc tgccaccaatacgtcattcacaacagcaagtgcatccccgagtgcccctctggctacacg atgaattccagcaaggaatcccaagggcctttgaagctctgtgccgggacctgggactgc catcaccgaggtcattctgaagaattggatatgccaagggtgtgtaaccagccccgccag tccctgccccctgctcacggtgcacctgttttccctttctcctttgcagacccttccgtc cccctggatccaatctccgtttctaactcctcgtcccagattattctgaagtggaagcct ccctctgatcccaatggcaacatcacacactacctggttttctgggagaggcaggtagaa gacagtgagctgtatgagctggattactgcctcaaagggttgaagctgccctcccggacc tggtctccgccgttcgaggccgagggctcccagaagcacaaccagagtgaatacgaggag tctgccggcgaatgttgctcctgccccaagacggactctcagatcctcaaggagctggag gagtcctcttttaggaagacctttgaggattacctgcacaatgtggtgttcgtccccaga aaatcctcttcaagccctggtgctgaggacactaggccatcgcggaaacgccgggccctc agggacgttgccaacgtgacggcggccgcgcccacggttccgggtttccccaacacctcg accagcgcgcccacgagcccggaggagcacaagcccttcgagaaagtggtgaacaaagaa tccctggtcatctctgggctgcgccacttcactggctatcgcatcgagctgcaggcttgc aaccaagactcccccgaggagaggtgcagcgtggcagcttacgtgagcgccaggaccatg cccgaagccaaggcagatgacattgttggccccgtgacccacgaaatcttcgagaacaat gtcgttcacctgatgtggcaggagccaaaggaacccaacggtctgatcgtgctgtatgaa gtgagttaccggcgctatggtgatgaggagctgcacctctgtgtctcccgcagacatttt gctctggagcggggctgcaggctgcgtgggctgccgccggggaattacagcgtgcgagtc cgggccacctccctggcgggcaacggctcgtggacagaagccacctatttctacgtgaca gactatttagatgtcccgtcgaatattgcaaaaatcatcatcggccccctcatctttgtc tttctcttcagtgttgtgattggaagtatctacctgttcctgagaaagaggcagccggat gggccactgggaccgctgtacgcgtcttcaaaccccgagtacctcagtgccagtgacgtc ttcccatgttctgtgtatgtgccggacgagtgggaggtgcctcgggagaagatcacgctc ctgcgtgagctggggcagggctccttcggcatggtgtacgaaggcaacgcgagggacatt gtcaagggcgaggcggagacccgcgtggcggtgaagacggtcaacgagtcggccagtttg cgggagaggatcgagtttctcaacgaggcctcagtcatgaagggcttcacctgtcatcac gtggtccgcctcctgggggtggtgtccaaaggccagccaacgctggtggtgatggagctg atggctcacggcgacctgaagagctacctccgctccctgcggccggaggctgagaataac cctggccgccctccccctaccctgcaagagatgattcagatggcggcggagattgccgac gggatggcctacctgaatgccaagaagtttgtgcaccgagatctcgcagcccgaaactgc atggtcgcccacgatttcactgtcaaaattggagattttgggatgaccagagacatctat gaaacggattactaccggaaaggaggcaagggtctgctccccgtgcggtggatggcaccg gaatccctgaaggacggggtctttaccacttcttctgacatgtggtccttcggcgtggtc ctttgggaaatcaccagcttggcagaacagccttaccaaggcctgtctaatgaacaggtg ttgaaatttgtcatggatggagggtatctggatcaacccgacaattgtccagagagagtc actgacctgatgcgaatgtgctggcagttcaatcctaagatgcggcccaccttcctggag atcgtcgacctgctcaaggacgacctgcaccccagctttccagaagtttccttcttccac agcgaggagaacaaggcgcctgagagtgaggagctggagatggagttcgaggacatggag agtgtccccctggatcgggcctcacactctcagagggaggaggccgggggccgggatgga gggtcctcactgggcctaaagcggaactacgaggagcatatcccctacacccacatgaac gggggcaagaaaaacggacggatcctgactctgccgaggtcgaatccttcctaa

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