Mycolicibacterium anyangense: MANY_47320
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Entry
MANY_47320 CDS
T07096
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
many
Mycolicibacterium anyangense
Pathway
many00860
Porphyrin metabolism
many01100
Metabolic pathways
many01110
Biosynthesis of secondary metabolites
many01120
Microbial metabolism in diverse environments
many01240
Biosynthesis of cofactors
Module
many_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
many_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
many00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MANY_47320 (hemD)
Enzymes [BR:
many01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MANY_47320 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MANY_47320 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
LpxD
Motif
Other DBs
NCBI-ProteinID:
BBZ79395
UniProt:
A0A6N4WEY8
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Position
4956768..4958459
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AA seq
563 aa
AA seq
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MTGHGSGRRKAKPGHITFVGSGPGDPNLLTTRARAVLANAALVFTDPDVPQAVLNVVGTE
LPPAVGPAPAPEKGAPREQIPGQDSDGPIADEIAPPVVSVGPDIRPALGDPAEVAKTLVA
EAKAGFDVVRLVAGDPLSIDAVITEVNAVAKAHAEFEIVPGLPATSAVPTYAGLPLGSAH
TVADVRGEVDWAALAAAPGPLILTATASHLPEAARTLIEYGLADSTPCVVTCNGTTCGQR
SVESTLAGLIDRATLAGGNDPAGPLTGTLVVTIGKTVAHRAKLNWWESRALYGWTVLVPR
TKDQAGEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVR
AVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGVSPELVPSGEQSSLGLLDEFPEYD
SIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFD
AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPETAAVGPLVDAL
AEHAARLRAEGALPPPRKKSRRR
NT seq
1692 nt
NT seq
+upstream
nt +downstream
nt
atgactggccacggtagcgggcgacgcaaggcgaagccgggacacatcacgttcgtcggt
tcgggtcctggcgaccccaacctgctgacgacacgtgcccgcgctgtgctcgccaacgcg
gcgctggtcttcaccgatccggacgtgccgcaggccgtgctcaacgtggtcggcaccgag
ctgccgcccgccgtcggccccgccccggctcccgagaagggcgcgccgcgcgagcagatc
cccggccaggattccgacgggcccatcgccgacgagatcgcgccgccggtggtgtcggtc
ggccccgacatccggcccgcgctgggtgaccccgccgaggtggccaagacgctcgtagcc
gaggcgaaggccggattcgacgtggtgcgtctggtggccggcgatccgctgtcgatcgac
gccgtcatcactgaggtgaacgcggtggccaaggcgcacgccgagttcgagatcgtcccc
gggttgcccgcgaccagcgcggtgcccacctacgcgggtctgccgctggggtcggcgcac
accgtggccgacgtccgcggcgaggtggactgggcggccctggccgccgcccccggcccg
ctgatcctgaccgccaccgcctcgcacctgccggaggccgcgcgcaccctgatcgagtac
ggcctggccgactcgaccccgtgcgtggtgacctgtaacggcaccacctgcgggcagcgt
tcggtggagagcacactggccggtctcatcgaccgcgccaccctggcgggcggcaacgac
ccggccggcccgctgaccggcaccctggtggtcaccatcggcaagaccgtcgctcaccgc
gcgaagctgaactggtgggagagccgtgccctctacggctggaccgtgctggtgccgcgt
accaaggaccaggccggtgagatgagcgatcggctggtcggtcacggcgcgttacccatc
gaggtgccgaccatcgccgtcgagccgccgcgcagccccgcccagatggagcgggccgtc
aagggtttggtggacggtcgctaccagtgggtggtgttcacctccaccaacgccgtgcgg
gcggtgtgggagaagttcggcgagttcggtctggacgcccgggcgttctccggggtgaag
atcgcctgtgtcggcgagtccaccgccgatcgggtgcgggccttcggtgtgagcccggaa
ctggtgccctccggtgagcagtcctcgctcggcctgctcgacgaattccccgagtacgac
agcattttcgacccggtgaaccgggtgctgctgccgcgggccgacatcgcgaccgagacg
ctggccgaaggcctgcgggaacgcggctgggagatcgaggacgtcactgcctaccgcacc
gtgcgggcggcaccgccgccggccgagacccgcgagatgatcaagaccggtggtttcgac
gcggtctgcttcacctccagctccacggtgcgcaacctcgtcggcatcgccggtaagccg
cacgcacgcaccatcgttgcgtgcatcggccccaagaccgccgagacggcagccgagttc
gggctgcgggtcgacgtccagcccgagaccgccgcggtgggtccgctggtcgacgcgctg
gccgagcacgctgcccggctgcgcgccgagggtgctctgccgcccccgcgtaagaagagt
cgccgccgctag
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