KEGG   PATHWAY: map00010Help
Entry
map00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glycolysis / Gluconeogenesis
map00010

All organismsOrtholog table
Module
M00001  
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:map00010]
M00002  
Glycolysis, core module involving three-carbon compounds [PATH:map00010]
M00003  
Gluconeogenesis, oxaloacetate => fructose-6P [PATH:map00010]
M00114  
Ascorbate biosynthesis, plants, glucose-6P => ascorbate [PATH:map00010]
M00265  
PTS system, glucose-specific II component [PATH:map00010]
M00266  
PTS system, maltose and glucose-specific II component [PATH:map00010]
M00268  
PTS system, arbutin-like II component [PATH:map00010]
M00272  
PTS system, arbutin-, cellobiose-, and salicin-specific II component [PATH:map00010]
M00307  
Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:map00010]
Disease
H00069  
Glycogen storage diseases (GSD)
H00071  
Hereditary fructose intolerance
H00072  
Pyruvate dehydrogenase complex deficiency
H00114  
Fructose-1,6-bisphosphatase deficiency
H00664  
Anemia due to disorders of glycolytic enzymes
H01071  
Acute alcohol sensitivity
H01096  
Pyruvate kinase (PK) deficiency
H01267  
Familial hyperinsulinemic hypoglycemia (HHF)
Other DBs
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
 
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