KEGG   Mastomys coucha (southern multimammate mouse): 116073764
Entry
116073764         CDS       T07224                                 
Symbol
Map2k1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mcoc  Mastomys coucha (southern multimammate mouse)
Pathway
mcoc01521  EGFR tyrosine kinase inhibitor resistance
mcoc01522  Endocrine resistance
mcoc04010  MAPK signaling pathway
mcoc04012  ErbB signaling pathway
mcoc04014  Ras signaling pathway
mcoc04015  Rap1 signaling pathway
mcoc04022  cGMP-PKG signaling pathway
mcoc04024  cAMP signaling pathway
mcoc04062  Chemokine signaling pathway
mcoc04066  HIF-1 signaling pathway
mcoc04068  FoxO signaling pathway
mcoc04071  Sphingolipid signaling pathway
mcoc04072  Phospholipase D signaling pathway
mcoc04114  Oocyte meiosis
mcoc04140  Autophagy - animal
mcoc04148  Efferocytosis
mcoc04150  mTOR signaling pathway
mcoc04151  PI3K-Akt signaling pathway
mcoc04210  Apoptosis
mcoc04218  Cellular senescence
mcoc04270  Vascular smooth muscle contraction
mcoc04370  VEGF signaling pathway
mcoc04371  Apelin signaling pathway
mcoc04380  Osteoclast differentiation
mcoc04510  Focal adhesion
mcoc04540  Gap junction
mcoc04550  Signaling pathways regulating pluripotency of stem cells
mcoc04613  Neutrophil extracellular trap formation
mcoc04620  Toll-like receptor signaling pathway
mcoc04650  Natural killer cell mediated cytotoxicity
mcoc04660  T cell receptor signaling pathway
mcoc04662  B cell receptor signaling pathway
mcoc04664  Fc epsilon RI signaling pathway
mcoc04666  Fc gamma R-mediated phagocytosis
mcoc04668  TNF signaling pathway
mcoc04720  Long-term potentiation
mcoc04722  Neurotrophin signaling pathway
mcoc04725  Cholinergic synapse
mcoc04726  Serotonergic synapse
mcoc04730  Long-term depression
mcoc04810  Regulation of actin cytoskeleton
mcoc04910  Insulin signaling pathway
mcoc04912  GnRH signaling pathway
mcoc04914  Progesterone-mediated oocyte maturation
mcoc04915  Estrogen signaling pathway
mcoc04916  Melanogenesis
mcoc04917  Prolactin signaling pathway
mcoc04919  Thyroid hormone signaling pathway
mcoc04921  Oxytocin signaling pathway
mcoc04926  Relaxin signaling pathway
mcoc04928  Parathyroid hormone synthesis, secretion and action
mcoc04929  GnRH secretion
mcoc04934  Cushing syndrome
mcoc04935  Growth hormone synthesis, secretion and action
mcoc05010  Alzheimer disease
mcoc05022  Pathways of neurodegeneration - multiple diseases
mcoc05034  Alcoholism
mcoc05132  Salmonella infection
mcoc05135  Yersinia infection
mcoc05160  Hepatitis C
mcoc05161  Hepatitis B
mcoc05163  Human cytomegalovirus infection
mcoc05164  Influenza A
mcoc05165  Human papillomavirus infection
mcoc05166  Human T-cell leukemia virus 1 infection
mcoc05167  Kaposi sarcoma-associated herpesvirus infection
mcoc05170  Human immunodeficiency virus 1 infection
mcoc05200  Pathways in cancer
mcoc05205  Proteoglycans in cancer
mcoc05206  MicroRNAs in cancer
mcoc05207  Chemical carcinogenesis - receptor activation
mcoc05208  Chemical carcinogenesis - reactive oxygen species
mcoc05210  Colorectal cancer
mcoc05211  Renal cell carcinoma
mcoc05212  Pancreatic cancer
mcoc05213  Endometrial cancer
mcoc05214  Glioma
mcoc05215  Prostate cancer
mcoc05216  Thyroid cancer
mcoc05218  Melanoma
mcoc05219  Bladder cancer
mcoc05220  Chronic myeloid leukemia
mcoc05221  Acute myeloid leukemia
mcoc05223  Non-small cell lung cancer
mcoc05224  Breast cancer
mcoc05225  Hepatocellular carcinoma
mcoc05226  Gastric cancer
mcoc05230  Central carbon metabolism in cancer
mcoc05231  Choline metabolism in cancer
mcoc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mcoc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    116073764 (Map2k1)
   04012 ErbB signaling pathway
    116073764 (Map2k1)
   04014 Ras signaling pathway
    116073764 (Map2k1)
   04015 Rap1 signaling pathway
    116073764 (Map2k1)
   04370 VEGF signaling pathway
    116073764 (Map2k1)
   04371 Apelin signaling pathway
    116073764 (Map2k1)
   04668 TNF signaling pathway
    116073764 (Map2k1)
   04066 HIF-1 signaling pathway
    116073764 (Map2k1)
   04068 FoxO signaling pathway
    116073764 (Map2k1)
   04072 Phospholipase D signaling pathway
    116073764 (Map2k1)
   04071 Sphingolipid signaling pathway
    116073764 (Map2k1)
   04024 cAMP signaling pathway
    116073764 (Map2k1)
   04022 cGMP-PKG signaling pathway
    116073764 (Map2k1)
   04151 PI3K-Akt signaling pathway
    116073764 (Map2k1)
   04150 mTOR signaling pathway
    116073764 (Map2k1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    116073764 (Map2k1)
   04148 Efferocytosis
    116073764 (Map2k1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    116073764 (Map2k1)
   04210 Apoptosis
    116073764 (Map2k1)
   04218 Cellular senescence
    116073764 (Map2k1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    116073764 (Map2k1)
   04540 Gap junction
    116073764 (Map2k1)
   04550 Signaling pathways regulating pluripotency of stem cells
    116073764 (Map2k1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    116073764 (Map2k1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    116073764 (Map2k1)
   04620 Toll-like receptor signaling pathway
    116073764 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    116073764 (Map2k1)
   04660 T cell receptor signaling pathway
    116073764 (Map2k1)
   04662 B cell receptor signaling pathway
    116073764 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    116073764 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    116073764 (Map2k1)
   04062 Chemokine signaling pathway
    116073764 (Map2k1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    116073764 (Map2k1)
   04929 GnRH secretion
    116073764 (Map2k1)
   04912 GnRH signaling pathway
    116073764 (Map2k1)
   04915 Estrogen signaling pathway
    116073764 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    116073764 (Map2k1)
   04917 Prolactin signaling pathway
    116073764 (Map2k1)
   04921 Oxytocin signaling pathway
    116073764 (Map2k1)
   04926 Relaxin signaling pathway
    116073764 (Map2k1)
   04935 Growth hormone synthesis, secretion and action
    116073764 (Map2k1)
   04919 Thyroid hormone signaling pathway
    116073764 (Map2k1)
   04928 Parathyroid hormone synthesis, secretion and action
    116073764 (Map2k1)
   04916 Melanogenesis
    116073764 (Map2k1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    116073764 (Map2k1)
  09156 Nervous system
   04725 Cholinergic synapse
    116073764 (Map2k1)
   04726 Serotonergic synapse
    116073764 (Map2k1)
   04720 Long-term potentiation
    116073764 (Map2k1)
   04730 Long-term depression
    116073764 (Map2k1)
   04722 Neurotrophin signaling pathway
    116073764 (Map2k1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    116073764 (Map2k1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116073764 (Map2k1)
   05206 MicroRNAs in cancer
    116073764 (Map2k1)
   05205 Proteoglycans in cancer
    116073764 (Map2k1)
   05207 Chemical carcinogenesis - receptor activation
    116073764 (Map2k1)
   05208 Chemical carcinogenesis - reactive oxygen species
    116073764 (Map2k1)
   05230 Central carbon metabolism in cancer
    116073764 (Map2k1)
   05231 Choline metabolism in cancer
    116073764 (Map2k1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    116073764 (Map2k1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    116073764 (Map2k1)
   05212 Pancreatic cancer
    116073764 (Map2k1)
   05225 Hepatocellular carcinoma
    116073764 (Map2k1)
   05226 Gastric cancer
    116073764 (Map2k1)
   05214 Glioma
    116073764 (Map2k1)
   05216 Thyroid cancer
    116073764 (Map2k1)
   05221 Acute myeloid leukemia
    116073764 (Map2k1)
   05220 Chronic myeloid leukemia
    116073764 (Map2k1)
   05218 Melanoma
    116073764 (Map2k1)
   05211 Renal cell carcinoma
    116073764 (Map2k1)
   05219 Bladder cancer
    116073764 (Map2k1)
   05215 Prostate cancer
    116073764 (Map2k1)
   05213 Endometrial cancer
    116073764 (Map2k1)
   05224 Breast cancer
    116073764 (Map2k1)
   05223 Non-small cell lung cancer
    116073764 (Map2k1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    116073764 (Map2k1)
   05170 Human immunodeficiency virus 1 infection
    116073764 (Map2k1)
   05161 Hepatitis B
    116073764 (Map2k1)
   05160 Hepatitis C
    116073764 (Map2k1)
   05164 Influenza A
    116073764 (Map2k1)
   05163 Human cytomegalovirus infection
    116073764 (Map2k1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    116073764 (Map2k1)
   05165 Human papillomavirus infection
    116073764 (Map2k1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    116073764 (Map2k1)
   05135 Yersinia infection
    116073764 (Map2k1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116073764 (Map2k1)
   05022 Pathways of neurodegeneration - multiple diseases
    116073764 (Map2k1)
  09165 Substance dependence
   05034 Alcoholism
    116073764 (Map2k1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    116073764 (Map2k1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    116073764 (Map2k1)
   01522 Endocrine resistance
    116073764 (Map2k1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcoc01001]
    116073764 (Map2k1)
Enzymes [BR:mcoc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     116073764 (Map2k1)
Protein kinases [BR:mcoc01001]
 Serine/threonine kinases: STE group
  STE7 family
   116073764 (Map2k1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Seadorna_VP7 Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 116073764
NCBI-ProteinID: XP_031201677
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgatggctcggcggtt
aacgggaccagctcggccgagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgagcagcagcggaagcgccttgaggcctttctgacgcagaagcagaaagtg
ggagaactgaaggatgatgactttgagaagatcagcgaactgggggctggcaatggtgga
gtggtcttcaaggtctcccacaagccatctggcctggttatggctagaaagctaattcac
ctggagatcaaacccgccatccggaaccagatcatccgggagctgcaggtgctgcatgag
tgcaactccccatacattgtgggcttctacggggccttctacagcgacggcgagatcagc
atctgcatggagcacatggatggcggctccttggatcaagttctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtgataaaagggctgacatatctt
cgggagaagcacaagattatgcacagagatgtcaagccttccaacattctagtgaactca
cgtggggagatcaaactctgtgattttggggtcagcgggcagctaattgactcaatggcc
aactccttcgtgggcacgaggtcctacatgtcgcctgagagacttcaggggactcactac
tctgtgcagtcggacatctggagcatggggctctctctggtggagatggcaattggaaga
taccccattcctcctcctgatgctaaggagctggagctgctatttggatgtcacgtggaa
ggagacgcagctgaaacgccacccaggccaaggactcctgggagacccctcagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacattgttaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaggattttgtgaataaa
tgcttaataaagaaccctgcagagagagcagatctgaagcagctcatggtacatgctttc
atcaaaagatctgatgccgaggaggtagacttcgcaggctggctctgctccaccattggg
ctgaaccagcccagcacaccaacccacgcagccagcatctga

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