KEGG   Mycolicibacterium doricum: MDOR_03580
Entry
MDOR_03580        CDS       T06662                                 
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
  KO
K13542  uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
Organism
mdr  Mycolicibacterium doricum
Pathway
mdr00860  Porphyrin metabolism
mdr01100  Metabolic pathways
mdr01110  Biosynthesis of secondary metabolites
mdr01120  Microbial metabolism in diverse environments
mdr01240  Biosynthesis of cofactors
Module
mdr_M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
mdr_M00926  Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:mdr00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    MDOR_03580 (hemD)
Enzymes [BR:mdr01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.107  uroporphyrinogen-III C-methyltransferase
     MDOR_03580 (hemD)
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.75  uroporphyrinogen-III synthase
     MDOR_03580 (hemD)
SSDB
Motif
Pfam: HEM4 TP_methylase
Other DBs
NCBI-ProteinID: BBZ06189
UniProt: A0A1X1T156
LinkDB
Position
365101..366762
AA seq 553 aa
MTRQESGRGRKMKPGRITFVGSGPGDPGLLTTRAHSVLVNAALVFTDPDVPEAVLSLVGA
HLPPPSGPEPAGPADGADEQAGWTIPGGPDIRPALGDPAEVAKTLAGEAKNGVDVVRLVA
GDPLSVDAVIAEVNALAKSHANFEIVPGLPDTTTVPTYAGLPLGSTHTVADVRGDVDWAA
IAAAPGPLILHGTASHLPDAARTLIEYGLAETTPVVVTANGTTCQQRSVESTLSGLIDKA
VLTGPDATGGPAAPLAGPLIVTLGRTVANRARLNWWESRALYGWTVLVPRTKDQAGEMSE
QLVGHGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFSEFG
LDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYDDIFDPVNRVL
LPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFDAVCFTSSSTV
RNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHAARLRAE
GALPPPRKKSRRR
NT seq 1662 nt   +upstreamnt  +downstreamnt
atgactcggcaggagagcgggcgcgggcgcaagatgaagccgggccgcatcaccttcgtg
ggctcgggcccaggcgaccccggcctgctgaccacacgggcgcacagtgtgctcgtcaac
gccgcgctggtcttcaccgaccccgacgtgcccgaagcggtgctgtccctggtgggtgcg
cacctgccgccaccgtcgggcccggaaccggccggaccagccgacggcgccgacgagcag
gcgggttggaccatccccggtggtccggacatccggcccgcgctgggcgacccggccgag
gtggccaagaccctggccggcgaggccaagaacggcgtggacgtggtccggctggtggcg
ggtgacccgctgtcggtcgacgccgtcatcgccgaggtgaacgcgctggcgaagagccac
gccaacttcgagatcgtgcccggcctgcccgacaccaccacggtgccgacgtacgcaggt
ctgccgctgggctctacccacaccgttgccgacgtgcgcggcgacgtggactgggcggcg
atcgccgcggcccccggtccgctgatcctgcacgggaccgcctcgcacctgcccgatgcg
gcgcgcacgctgatcgagtacggcctggccgagaccacccccgtggtggtgaccgccaac
ggcaccacctgccagcagcgttctgtcgagtcgacgctgtccggcttgatcgacaaggcc
gtgctgaccggaccggacgccaccggcgggcccgcggcgccgctggccggaccgctgatc
gtgacgctcggccgcactgtcgccaaccgggcccggctcaactggtgggagagccgcgcg
ctgtacggctggaccgtgctggtgccgcggaccaaggaccaggcgggcgagatgagcgag
cagctcgtcggccacggtgcgctgccggtcgaggtgccgaccatcgccgtcgaaccgccc
cgcagccccgcgcagatggagcgggcggtcaagggtctggtcgacggtcgcttccagtgg
gtggtgttcacctccaccaacgcggtgcgcgcggtctgggagaagttcagcgagttcggg
ctcgacgcccgcgcattctccggggtgaagatcgcctgcgtcggtcaggcgacggcagag
cgggtccgcgcattcggcatcaaccccgagctggtcccgacgggcgagcagtcgtcgctg
ggtctgctcgacgagttcccgccctacgacgacatcttcgatccggtgaaccgggtactg
ctgccgcgggccgacatcgccaccgagacgctggccgaggggctgcgcgaacgcgggtgg
gagatcgaggacgtcaccgcgtaccggacggtgcgcgccgcgccgccgccggcctcgacc
cgcgagatgatcaagacgggtggcttcgacgcggtgtgcttcacgtcgagttcgacggtg
cgcaacctcgtcggcatcgccggtaagccgcacgcccgcacgatcgttgcctgcatcggg
ccgaagaccgcggagaccgccgccgagttcggtctgcgcgtcgacgtgcagcccgaagtg
gccgctgtgggtccgctcgtggaggcgctcgccgagcacgcggcccggctgcgcgccgag
ggggcgctgccgccgccgcgcaagaagagccgccgccgctaa

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