Mycolicibacterium fallax: MFAL_22290
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Entry
MFAL_22290 CDS
T06894
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mfx
Mycolicibacterium fallax
Pathway
mfx00860
Porphyrin metabolism
mfx01100
Metabolic pathways
mfx01110
Biosynthesis of secondary metabolites
mfx01120
Microbial metabolism in diverse environments
mfx01240
Biosynthesis of cofactors
Module
mfx_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mfx_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mfx00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MFAL_22290 (hemD)
Enzymes [BR:
mfx01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MFAL_22290 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MFAL_22290 (hemD)
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GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
BBY98762
UniProt:
A0A1X1RDK4
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Position
complement(2317934..2319577)
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AA seq
547 aa
AA seq
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MTTRVRKAKPGLITFVGSGPGDPGLLTMRAKAVLGHAALVFTDPDVPESVLRLVGAELPP
AVGPARAPEGDEKATAAANPAVLSGDADVRPALGDPAEVAKTMVAEARRGHDVVRLVFGD
PLSLDPVLAEVNAVAKTQVGFEIVPGLPATTAVPTYGGLPLGSSHTVADVRGDVDWAALA
AAPGPLILQAGPEHLADAARTLIEYGLAENTACVVTAQGTTCQQRSVETTLGGLTDRAAL
GGTDPAGPLTGPLVVTIGRTVSHRARLNWWESRALYGWTVLVPRTKDQAGEMSDRLVCHG
AVPMEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKFAEFGLDARAF
SGVKIACVGEATAERVRAFGISPELVPAGEQSSLGLLDEFPPYDDIFDPVNRVLLPRADI
ATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQTREMIKTGGFDAVCFTSSSTVRNLVGI
AGKPHARTIVACIGPKTAETAAEFGLRVDVQPETAAIGPLVDALAEHAARLRAEGALPPP
RKKSRRR
NT seq
1644 nt
NT seq
+upstream
nt +downstream
nt
atgaccacgcgagtgcgtaaggccaagccgggcctcatcacgttcgtgggctcggggccc
ggtgatccggggctgctgacgatgcgggcgaaggcggtgttgggtcacgcggcgctggta
ttcaccgaccccgacgtgcccgagtccgtgctgcgcctggtcggcgccgaactgccgccg
gccgtcgggcccgcgcgcgcccccgagggtgacgagaaggccaccgccgcggcgaacccg
gccgtgctgtccggtgacgccgacgtgcgcccggccctcggcgatccggccgaggtggcc
aagacgatggtggccgaggctcgccgcggtcacgacgtggtgcgcctggtcttcggtgac
ccgctgtcgctggacccggtgctcgccgaggtcaacgccgtcgccaagactcaggtcggc
ttcgagatcgtgcccgggctgccggcgaccaccgcggtgcccacctacggcggcctgccg
ctgggctcctcgcacaccgtcgccgacgtccgcggcgacgtggactgggcggcgctggcc
gccgcgcccggcccgctgatcctgcaggccggccccgagcacctcgccgacgccgcccgc
accctgatcgagtacggcctggccgagaacaccgcctgcgtggtgaccgcgcagggcacc
acctgccagcagcgttcggtggagaccaccctcggtggcctgaccgaccgggccgccctc
ggcggcaccgacccggccggcccgctgaccggcccgctggtggtgaccatcggccgcacg
gtgtcgcaccgggcgcggctgaactggtgggagagccgcgccctgtacggctggaccgtg
ctggtgccgcgcaccaaggaccaggccggcgagatgagcgaccggctggtctgccacggc
gcggtgccgatggaggtgccgaccatcgccgtcgagccgccgcgcagccccgcccagatg
gagcgcgcggtcaagggcctggtcgacggccgctaccagtgggtggtgttcacctcgacc
aacgccgtgcgcgcggtgtgggagaagttcgccgagttcggcctggacgcccgggcgttc
tccggggtcaagatcgcctgcgtgggcgaggcgaccgccgagcgggtgcgggccttcggc
atcagccccgagctggtgcccgccggtgagcagtcctcgctggggctgctcgacgagttc
ccgccctacgacgacatcttcgacccggtgaaccgggtgctgctgccgcgcgccgacatc
gccaccgagacgctggccgaggggctgcgggaacgcggctgggagatcgaggacgtcacc
gcctaccggaccgtgcgggcggcgccgccgccggcgcagacccgggagatgatcaagacc
ggcgggttcgacgccgtgtgcttcacctccagctcgacggtgcgcaacctggtcggcatc
gccggcaagccgcacgcgcgcaccatcgtcgcctgcatcggcccgaagacggccgagacg
gccgccgagttcgggctgcgggtcgacgtgcaaccggagaccgccgcgatcgggccgctg
gtcgacgcgctggccgagcacgccgcccggctgcgcgccgagggcgcactgcccccgccg
cgcaagaagagccggcgccggtaa
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