Manis javanica (Malayan pangolin): 108393233
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Entry
108393233 CDS
T06054
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
mjv
Manis javanica (Malayan pangolin)
Pathway
mjv00310
Lysine degradation
mjv01100
Metabolic pathways
mjv05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
mjv00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
108393233 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
108393233 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
mjv03036
]
108393233 (DOT1L)
Enzymes [BR:
mjv01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
108393233 (DOT1L)
Chromosome and associated proteins [BR:
mjv03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
108393233 (DOT1L)
HMT complexes
Dot1-containing complex
108393233 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DOT1
Motif
Other DBs
NCBI-GeneID:
108393233
NCBI-ProteinID:
XP_017509408
LinkDB
All DBs
Position
Unknown
AA seq
1696 aa
AA seq
DB search
MENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQV
YNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVA
AATSCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIAN
TSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVV
ELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRDSKSSTA
TPTKAPVDTPMDSGAEEEKAGTTAIKKPPPSRARKKKLSKKGRRLAGRKRGRPKKAGTAH
PERRPRRGQAALDLLHAQTLSQTASPTPQDVYKSPHSPFYQLPPSVQRHPPDQLLLAPTP
PALQKLLESFRIQYLQFLAYTKTPQYKATLQQLLGQEKEKNAQLLGAARQLLGHCQAQKE
EIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQAAQLDKDTRQLRAQSLQLLK
ARCEELRLDWSTLSLEGLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQELLQLKS
CAPPDDALCARLRGKGVLGRELEAGPGRLHLERDCPPLPPPPLSSMSPELSMNGRAAGYE
LCGTLSRPSSKQSPPQHLATPLDQEVVPCTPSHGSRPRLEKLSSLALPDYTRLSPAKLVL
RRHLSQDHAAGGKVAAGELHARAEHAKENGLLYQSPGLANGIKLSPQDLRPSSPGALQMA
GERSGEKGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRSTP
SPVPQTRESSALEKQLVANAHGAGSKSLALAAAGFSYAGSMAISGALSCSPAPLPPGAEP
AAFDDPPTSGGLFTPVGSHSSTPQHPPLLVQPRNSGSASPAHQFCASPRLGSAPQGLLLD
SSKGDLVPEAGFSDPESEVKRRVIFTGTAAGGTRPPPPSKHSPLPSGARGDSGQSLGQDS
RKRGRRKRASAGTPSLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAI
SSPESLQSSPVPSQDDDQPPVLKKERPLGQSNGAHCSPPTSDEEQGSEDEPSSARARGAA
GSLSNITCNFVRNGQVAPQLLPSHIPASHMQASGFPTSWAVIERKIATISLESKSPPKTL
ENGGGLVGRKPAPASEPVNSSKWKSTFSPISDLGLAKSSDSPLQAGCALSQNSLFAFRPP
LEEPCSTDGKLAAHPRKSFPGTLVGPGGLSPSSNPPNGFAFSGGLATDLSLHGFSDGAPL
SHKAPEPAGLGAPSSFPAPRGKEGGTTEPGPFVHKRQLDGLGGPKAEGGKSREAGELGLP
VCGPSDRAPLGHGRTGRSRDREPDFKNGHNLFISATAVPPGGLLSNPGLATVAAPASSVA
PPAQTHRPFLGSFAPGPQFALGPMSLQANLGSSVLQSLFSSVPAAAGLVHVSSATTRLTN
SHAIGSFPSGVAGGTVGGVFNHAVPSASTHPFGASFGSGAACRSATLSLTPLQAVASAPA
SNFQAPHCVEPRPPPPAPGRAPAGPRAPALLPAPSEPALLQSLAPLPAAPAFLPAPASSA
ASLPPANASLSIKLASLPHKAPRPHLAVHQQPLPGLTLARAAPGTPQPGSTGPPAVWVSL
GMPPPYAARLAGVKPR
NT seq
5091 nt
NT seq
+upstream
nt +downstream
nt
atggagaattacgtcctaatcgactacgataccaaaagtttcgaaagcatgcagagactc
tgcgacaagtacaaccgggccattgacagcatccaccagctgtggaagggaaccacgcag
cccatgaagctgaacacgcggccgtccaacgggctcttgaggcacatcctgcagcaggtg
tataaccactcggtgaccgaccctgagaagctcaacaactacgagcccttctccccagag
gtgtatggggagacctccttcgacctggtcgcgcagatgatcgacgagatcaagatgacc
gaggacgacctgttcgtggacctgggcagtggagtgggccaggttgtgctgcaggtcgct
gcggccaccagctgcaaacatcactatggcgttgagaaagctgacatcccagccaagtac
gcggagaccatggaccgagagttcaggaagtggatgaaatggtacggaaaaaagcatgca
gaatacacactggaaaggggcgacttcctgtcagaagagtggagagaacggatcgccaac
acgagtgttatatttgtgaataactttgcctttggtcctgaggtggatcaccagctgaag
gagcggtttgcaaacatgaaggaaggtggcagaatcgtctcctcgaagccctttgcacct
ctgaacttcagaataaacagtagaaacttgagtgacatcggcaccatcatgcgtgttgtg
gagctctcaccgctgaagggctcggtgtcgtggacagggaagccagtctcctactacctg
cacacgatcgaccgcaccatacttgaaaattatttttctagtctgaaaaatccaaaactc
agggaggaacaagaggcggcccggcgccggcaacagcgggacagcaagagcagcacagcc
acccccaccaaggcgcctgtggacacccccatggattctggtgctgaggaggagaaagca
gggacgactgccatcaagaagccgcccccctccagagcccggaagaagaagctcagcaag
aagggacggaggctggccggccggaagcgcgggcgccccaagaaggcgggtactgcacac
ccggagcgcaggcccaggaggggccaagctgccctggacctcctgcacgcccagaccctg
tctcagaccgcatcgcccacgccacaggacgtgtacaagtcacctcacagccccttctac
cagctacctcccagcgtgcagcggcacccccccgaccagctgctgctggcgcccaccccg
cccgcactgcagaagctgctagagtcgttcaggattcagtacttgcagttcctggcgtac
acaaagaccccgcagtacaaggccaccctgcagcagctgctgggccaggagaaggagaag
aacgcccagctgctgggtgccgcacggcagctgctggggcactgccaggcccagaaggag
gagatcaggaggctcttccagcagaaactggatgagctgggggtgaaggctctgacctac
aatgacctgattcaagcacagaaggagatctcggctcataaccagcagctgagggagcag
gcagcgcagctggacaaggacacccggcagctgagggcccagagcctgcagctgctcaag
gctcgctgcgaggagctgaggctggactggtccacgctgtccctggagggcctcctgaag
gagaagcaggccctgcgcagccagatctccgagaagcagcggcactgcctggagctgcag
atcagcatcgtggagctggagaagagccagcggcagcaggagctcctgcagctcaagtcc
tgtgcgccacctgacgacgcgctgtgtgcgcgcctgcgagggaaaggcgtactgggccgg
gagctggaggcggggccgggccggctgcacctggagcgggactgccccccgctccccccg
ccgcccttgagcagcatgagcccagagctctctatgaacgggcgcgcggccggctacgag
ctctgcgggactctgagccggccctcctccaagcagagccccccccagcacctggccacc
cccctggaccaggaggtcgtgccctgcactcctagccacggcagcaggcccaggctcgag
aagctgtccagcctggctctgcccgactacaccaggctctccccagccaagctggtactg
cggcggcacctgagccaggaccatgctgccggtggcaaggtggctgccggtgagctgcac
gcacgagctgagcacgccaaggagaatggccttctctaccagagccctggcttggccaac
ggcatcaagctgagccctcaggacctgcggccctcgtcccccggggccttgcagatggct
ggagagaggagtggtgagaagggtgtgaaggagcgcgcctatgccagcagtggggaagcc
atcaccagcctgccggtcagcatcccgctcagcactgtgcagcccagcaagctgcccgtc
agcatccccctggccagcgtggtgctgcccagccgtgccgagaaagtgagaagcactccc
agcccagtgccgcagacccgagagtcgtctgcacttgaaaagcagctggttgctaatgcc
cacggtgccggaagcaagagccttgccctggcagctgcaggcttctcctacgccggctcc
atggccatcagcggggccttgtcgtgcagcccggcaccacttcctcccggagctgagcct
gcagcctttgatgatccccccacctcgggaggcctcttcactcctgtggggtcccacagc
tccacccctcagcaccccccactgctagtgcagccccgcaactctggctcagcctcacct
gcccaccagttctgtgccagcccccggctcggcagcgccccccagggcctgctcctagac
tccagcaaaggggacctggttcccgaagctggcttctcggacccagagagcgaagtcaag
agaagggtcatcttcactggcacggccgctggcggcaccaggccgccaccccccagcaag
cacagccctctgccatcgggtgctcgcggagacagtggccagagccttgggcaggatagc
cgcaagcggggcaggaggaagcgggcatcagcagggacccccagcctgagctcaggtgtg
tcccccaagcgccgggccctgccatctgttgctggcctcttcacgcagtcttcagggtct
cccctgaacctcaactccatggtcagcaacattaaccagcctctggagatcactgccatc
tcgtcccctgagagcctgcagagctcccctgtcccttcccaggacgacgaccagccgccc
gtgctcaagaaggagaggcccctgggccagagcaatggggcccactgctccccaccaacc
tcggacgaggagcagggctctgaggatgagcccagcagcgccagagctcgtggagctgcc
gggtcccttagtaacatcacgtgtaactttgtgcggaacggccaagtcgccccacagctg
ctgccgtctcacattcccgccagccatatgcaagcgtcaggcttccccacgtcctgggcg
gtaattgagaggaaaattgcaaccatctccttagaaagcaaatctcctccgaaaaccttg
gaaaatgggggcggcctggtgggaaggaagccggcgcctgccagtgagcccgtcaacagc
agcaagtggaagtccaccttctctcccatctctgacctcggcctggccaagtcctccgac
agcccgctgcaggctggctgcgctctgagccagaactccctgtttgctttccggcccccc
ctggaggagccctgctcgactgatggcaagctggctgcccaccccaggaagagctttccg
ggcaccctggtggggcccggcgggctgagcccgagcagcaaccctcccaacggctttgcc
ttcagcgggggcctggccaccgacctcagcttacacggcttcagtgatggtgctcctctg
tcccacaaggcccccgagccggccggcctgggtgccccctcgagctttcctgccccacgg
ggcaaggagggtggcaccacggagcccggcccctttgtgcacaagaggcagctggacgga
ctcggtggcccgaaggccgagggcggcaagagcagggaggcgggcgagctgggcctgccc
gtgtgcgggccctcggacagggcacctctcgggcacggcagaacaggcaggagccgggac
cgggagcccgacttcaagaacggccacaacctcttcatttccgccactgccgtgcctccc
gggggcctcctcagcaaccccggccttgccacggtggcagccccggcgagtagcgtggcg
ccccccgcgcagacgcaccggcccttcctgggctccttcgcgcctggtccgcagttcgcg
ctgggccccatgtccctgcaggccaacctgggctcatctgtgcttcagtccttgttcagc
tctgtgccagctgccgccgggctggtgcacgtctcgtccgccacaaccagactgaccaac
tcgcacgccataggcagctttccctcgggggtggcgggcggcacagtcggaggtgtcttt
aaccacgcggtgccttccgcctccactcatccgtttggagccagtttcggcagcggggct
gcgtgtcgcagcgccacgctgagcttaaccccactgcaggcggtggccagcgcgcccgcc
tctaactttcaggccccgcactgcgtggagccgcggccaccccctccagctccaggccgg
gcccccgcagggccgcgcgcccccgcactgctgccggctccctccgagccggcgctcctg
cagagcctcgcgcccctgcccgccgccccggccttcttgcccgcgcccgcctcctctgcc
gcctctctgccgcctgctaacgcctctctgtccatcaagcttgcctccctcccgcacaag
gccccccgcccccacctcgcggtgcaccagcagcctctgcctgggctgaccctggcccgg
gccgcccctgggaccccgcagcccggctccacggggccgcccgccgtatgggtttccctt
ggcatgccacctccatatgccgcgcgccttgcgggggttaagccgcgataa
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integrated database retrieval system
