Mycobacterium lacus: MLAC_36450
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Entry
MLAC_36450 CDS
T07377
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mlj
Mycobacterium lacus
Pathway
mlj00860
Porphyrin metabolism
mlj01100
Metabolic pathways
mlj01110
Biosynthesis of secondary metabolites
mlj01120
Microbial metabolism in diverse environments
mlj01240
Biosynthesis of cofactors
Module
mlj_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mlj_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mlj00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MLAC_36450 (hemD)
Enzymes [BR:
mlj01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MLAC_36450 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MLAC_36450 (hemD)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Inhibitor_I78
Motif
Other DBs
NCBI-ProteinID:
BBX98351
UniProt:
A0A1X1YSB4
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All DBs
Position
complement(3872110..3873813)
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AA seq
567 aa
AA seq
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MTTRGRKPRPGRITFVGAGPGDPGLLTTRAATVLANATLVFTDPDVPQPVLALIGKDLPP
VSGPAPAEPAPGNAHAAGPDGDQGTAPAVMAVMSGAPDIRPAVGDPAEVAKTLTAEARTG
SDVVRLVAGDPLTVDAVITEVNAVARTHLHIEIVPGLAATTAVPTYAGLPLGSSHTVADV
RLDPDNTDWEALAAAPGPLILQATASHLAHAARTLIDHELAESTPCVVTAHGTTCQQRSV
ETTLQGLTDPAVLGITDAGPSPASGGVPLTGPLVVTIGKTVASRAKLNWWESRALYGWTV
LVPRTKDQAGEMSERLTSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTST
NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSIGLLDDF
PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT
GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAVGPL
VDALAEHAARLRAEGALPPPRKKSRRR
NT seq
1704 nt
NT seq
+upstream
nt +downstream
nt
atgacgacgcgagggcgcaagccgcgaccgggccgcatcacgttcgtgggcgccggtccg
ggcgacccgggattgctgacgactcgggccgccacggtgctggcgaacgcgaccctggtg
ttcaccgaccccgacgtaccccagccagtgctagccctgatcggcaaggatctgccaccg
gtctccggaccggcgcccgccgaaccggcccccggaaacgcccacgctgccggccccgac
ggagaccaaggcaccgccccggcggtgatggcggtgatgtccggggcccccgacatccgt
ccagcggtgggtgaccccgccgaggtcgccaagacgctgaccgccgaggcccggacgggt
agcgacgtggtgcggctggtggcgggtgatccgctgacggtcgacgccgtcatcaccgag
gtgaacgccgtcgcacgcacccacctgcacatcgagatcgttccgggcctggctgcgacc
accgcggttccgacctatgccgggctgccgctgggctcgtcgcacacggttgccgacgtc
cgcctcgaccccgacaacacagactgggaagcgctggccgccgcacccgggccgctgatc
ctgcaggccaccgcgtcgcatctggcccacgcggcacggaccctgatcgaccacgaattg
gccgagtccaccccgtgcgtggtgaccgcgcacggcactacctgtcagcagcgttcggtc
gagaccaccctgcagggactgaccgacccggccgtcctggggatcaccgacgcggggccg
tcgccggcaagcggcggcgttccgttgaccggcccgctggtggtgaccatcggcaagacg
gtggccagccgggcgaagctgaattggtgggagagccgggccctgtacggctggaccgtc
ttggtgccgcgcaccaaggaccaggccggcgagatgagcgagcggctgacgtcctacggc
gccctgccgatcgaggtgccgaccatcgccgtcgagccgccgcgcagccccgcccaaatg
gagcgcgccgtcaagggtctggtcgacggccggttccagtgggtggtgttcacctcgacc
aatgcggtccgtgcggtgtgggagaagttcggtgagttcggcctggacgcgcgcgccttc
tccggggtgaagatcgcctgcgtcggcgagtcgaccgcggaccgggtccgtgccttcggg
atcagccccgagttggtgccatccggggagcagtcctcgatcggtctgctggacgacttc
ccgccctatgacagcgttttcgacccggtgaaccgggtgctgttgccgcgcgcggacatc
gccaccgaaacgctcgccgaaggactgcgcgagcggggctgggagatcgaggacgtcacc
gcctaccggaccgtgagggctgccccgccgccggcgactacccgcgaaatgatcaagacg
ggtgggttcgacgcggtgtgcttcacctcgagctcgacggtgcgaaacctggtcggcatc
gcgggcaagccgcacgcgcggacgatcatcgcctgcatcggtccgaagaccgcagagacc
gccgccgagttcggcttgcgggtggatgtccagcccgataccgccgcggtgggtccgctg
gtcgatgcgctggccgaacacgccgcgcggctgcgcgcagagggggcgctgccaccgccg
cgcaagaagagccgcaggcgttag
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