Mustela lutreola (European mink): 131823234
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Entry
131823234 CDS
T09578
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
mlk
Mustela lutreola (European mink)
Pathway
mlk00310
Lysine degradation
mlk01100
Metabolic pathways
mlk05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
mlk00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
131823234 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
131823234 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
mlk03036
]
131823234 (DOT1L)
Enzymes [BR:
mlk01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
131823234 (DOT1L)
Chromosome and associated proteins [BR:
mlk03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
131823234 (DOT1L)
HMT complexes
Dot1-containing complex
131823234 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
131823234
NCBI-ProteinID:
XP_059015314
LinkDB
All DBs
Position
2:1370768..1428735
Genome browser
AA seq
1706 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSATTTPTKGP
ESKAAASADAPTDSGAEEEKAGATTIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERKPKKSQTALDLLHAQAAPQTAAPSPQDAYKSPQSPFYQLPPSVQRHPPDQLLLAPT
PPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQKDNGELRTQSLRLL
KARCEELKLDWSTLSLENLLKEKQALRTQISEKQRHCLELQISIVELEKSQRRQELLQLK
SCVPPDDGLSAHLRGKGALGRELEAEPGRLHLDLDGPKFSLPHLSSASPELSMNGHVAGY
EVCGALSRPSSKQNTPQYLASPLDQDVVPCTPSHGGRPRLEKMAGLALPDYTRLSPAKLV
LRRHLSQDHAAGGKPAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPAALQM
TGERGSEKGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRST
PSPVSQTRESSSTLEKQMGANAHGAGSKNLAPASTGFYTGSGAVSGTLAGSPAPLAPGAE
PGTLDEVSSSGSLFAGMGSCGSAPQLPPLLQQSRSSGAASPAHPLCASPRLSSAAQGPLP
EANKGDLPSEAGVSDPEGEAKRRIVFTISAGGGAKQSPPGKPSPLPTSARGDSGQGHGPD
SRKRGRRKRAAAGTPSLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITA
ISSPESLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSARIERK
IATISLESKSPPKTLESGGGLTGRKPAPASEPANSSKWKSTFSPISDLGLAKCADSPLQA
SSALSQNSLFAFRPPLEEPGLADAKLAAHPRKGFPGALAGAGGLSPSSNPPNGFAFSGGL
TADLSLHSFSDGASLSHKAPETASLSGPLSFPTPRGKEGAAAEPGTFVNKRQLDGLSGPK
AREAGEPGLPACGPPDKASLTHSKPGKGRDREPDLKNGHNLFISAATVPPGGLLSGPGLA
TVASSTVSAAPSAQTHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFSSVPAAAGLVH
VSSAATRLTNSHAMGSFSSGVAGGAVGGVFNHAVPSASAHPFGASFGSGAACRSGTLGLT
ALQAVAGAPASSFQAPPPPPQGQPALPAPPPPNAALPPAPALLPANSEPVLLQNLASLPA
NQAFLPASSAASLQPANASLSIKLTSLPHKAPRPSFTVHHQPLPGLALAQAAPVIPQASS
TGPSAVWVSLGMPPPYAARLAGVKPR
NT seq
5121 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcacgaaatcatcgagacc
atccggtgggtctgtgaggagatcccggacctcaagcttgctatggagaattacgttctc
atcgactacgacaccaaaagcttcgaaagcatgcagaggctctgtgacaagtacaaccgc
gccatcgacagcatccaccagctgtggaaggggaccacgcagcccatgaagctgaacacg
cggccgtccaacgggctcctgcggcacatcctgcagcaggtctacaaccactcggtgacg
gaccccgagaagctcaacaactacgagcccttctccccggaggtgtacggggagacgtcc
tttgacttggtcgctcagatgatcgacgagatcaagatgaccgaggacgacctgtttgtg
gacctgggcagtggagtgggccaggtcgtgctacaggtcgccgcggccaccaactgtaag
catcactacggcgtggagaaagcggacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagaga
ggcgacttcctctcagaggagtggagagagcggatcgccaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgccaacatg
aaggaaggtggcagaatcgtgtcctcgaagcccttcgcacctctgaactttagaataaac
agcaggaacttgagcgacatcggcaccatcatgcgggtcgtagagctctcgcccctgaag
ggctcagtgtcctggacggggaagccggtctcctactatctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggagcaagaggca
gctcggcggcggcaacagcgggaaagcaagagcgccacgaccactcccaccaaggggccc
gagagcaaggctgccgcgtctgcggacgccccgacggattcgggggccgaggaagaaaaa
gctggggcaaccaccatcaaaaagccgtccccctccaaagcccggaaaaagaagctgaac
aagaaggggcggaagatggctggccggaagcgcgggcgccccaagaagatgagcactgcg
aaccccgagcgtaagcccaagaagagccaaaccgcactggacctcctgcacgcccaggcc
gcgccgcagacggcagcgccctcgccgcaggacgcgtacaagtcacctcagagcccgttt
taccagctacctcccagcgtgcagcggcacccccccgaccagctgctgctggctcccacc
ccgcccgcactgcagaagctgctagagtccttcaagattcagtacttgcagttcttggcc
tacaccaagaccgcccagtataaggccagcctgcagcagctgctggaccaggagaaggag
aagaacgctcggttgctgggcgccgcgcagcagctatttggccactgccaggcccagaag
gaggagatcaagaggctcttccagcagaagctggacgagctgggagtgaaggcgctgacc
tacaacgacctgatccaggcgcagaaggagatctcggcccacaaccagcagctgcgggag
cagacggagcagctgcagaaggacaacggggagctgaggacgcagagcctgcggctgctc
aaggctcggtgtgaggagctgaagctggactggtccacgctgtccctggagaacctgctg
aaggagaagcaggccctgaggacccagatctccgagaagcagaggcactgtctggagctg
cagatcagcatcgtggagctggagaagagccagcggcggcaggagctcctgcagctgaag
tcgtgcgtgccgcccgacgacggcctgtccgcacacctgcgtgggaagggcgccctgggc
cgggagctggaggctgagcctggccgtctgcacctcgacctggacggccccaagttctca
ctgccccacttgagcagcgccagcccggagctctccatgaacggccacgtggccggctac
gaggtgtgcggtgcgctgagccggccctcgtccaagcagaacacgccccagtacctggcc
tccccgctggaccaggacgtcgtgccctgtactcccagccatggtggccggccgcggctc
gagaagatggcgggcctggccttgcccgactatacccggctctccccggccaagctggta
ctcaggcggcacctgagccaggaccatgcagccggcggcaagcctgcggccggcgagcta
cacccacgagctgagcacgccaaggagaacggccttccataccagagccctggcatcgcc
aacggtatcaagctgagccctcaggacccgcgaccgtcctcccccgccgccttacagatg
acaggggagaggggcagcgagaagggtgtgaaggagcgcgcctacgccagcagcggggag
gccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcccagcaaactgccc
gtcagcatccccctggccagcgtggtgctgcccagccgcgccgagaaggtgagaagcacc
cccagccctgtgtcacagacccgagagtcctcgtccacacttgaaaagcagatgggcgct
aatgcccacggcgctggaagcaaaaacctcgctccagcttctacaggcttctacacgggc
tccggggccgtcagcgggaccctggcaggcagcccggctcccctcgctcccggagccgag
cccggcaccttggatgaggtctcgagctcaggaagcctgttcgctggcatggggtcctgt
ggctccgccccgcagctcccgcccctgctccagcagtcccgcagctccggtgcggcctct
cctgcccatccgctctgcgccagcccgcggctcagcagcgctgcccagggcccgctgccc
gaggccaacaaaggggaccttccctctgaggcgggcgtctccgaccccgagggcgaggcc
aagaggaggatcgtctttaccatctcggctggcggcggtgccaaacagtcgcctcctggc
aaacccagccctctgcccacgagcgcccgtggggacagcggccaaggccatgggccggac
agccgtaagcggggcaggaggaagcgggcggcggccgggacccccagcctgagttccggc
gtgtcgcccaagcgtcgggcactgccctccgtcgccggcctcttcacacagtcttcaggg
tccccgctgaacctcaactcgatggtcagcaacattaaccagcctttggaaatcacggcc
atctcgtcccctgagagcctgaagagctcccctgtcccttaccaggacaatgaccagcca
cccgttctcaagaaggagaagcccttgagccagaccaacggggcccactactccccactg
acctcagacgaggagcagggctccgaggacgagccgggcagcgccagaattgagaggaaa
attgcaaccatctccttagaaagcaaatctcctccgaaaaccttggaaagcggtggtggc
ctgaccgggaggaagccggcgcctgccagcgagcccgccaacagcagcaagtggaaatcc
accttctcgcccatctccgaccttggcctggccaagtgcgccgacagcccgctgcaggcc
agctccgccctgagccagaactccctgttcgctttccggccgcccctggaggagcctggc
ctggccgatgccaagctggctgcccacccgaggaagggctttcccggtgccctggcgggg
gccgggggactgagccccagcagcaaccctcccaacggcttcgccttcagcgggggcctg
accgccgacctcagtttacacagcttcagcgatggtgcttctctctcccacaaggccccg
gagacggccagcctgagcggccccctgagctttcccaccccgcggggcaaggagggcgcc
gccgcagagcctggcacctttgtgaacaagaggcagctggacggactgagtggccccaag
gccagagaggcgggcgagccgggccttccggcgtgtgggcctccagacaaggcctcgctg
acgcacagcaagccgggcaagggccgggaccgcgagcccgacttgaagaacggccacaac
ctcttcatttctgccgccactgtgcctcccgggggccttctcagcggcccgggcctcgcc
acagtggcgtcctcgacggtcagcgcggctccctctgcccagacacaccgccccttcctg
ggcacctttgcccccggcccacagttcgccctgggtcccatgtccctgcaggccaacctg
ggctcctccgtgctgcagtccctgttcagctctgtgccggccgccgccggcctggtgcac
gtctcgtccgccgcgaccagactgaccaactcgcacgccatgggcagcttctcctctggg
gtggcaggcggcgcagttggaggtgtctttaaccacgcggtgccttccgcctccgcccat
ccgtttggagccagtttcggcagcggggctgcgtgtcgcagcggcacgctgggcttaacc
gcgctgcaggcggtggctggcgcccccgcgtcttcctttcaggccccgcccccgccccca
caggggcagcccgccctccccgcacccccaccccctaacgctgccttgcctcctgcccct
gcgctgctcccggctaactctgagcccgtgcttctgcagaacctcgcgtccctcccggct
aaccaggctttcttacccgcctcctctgccgcctctctgcagcctgctaacgcctctctg
tccatcaagctcacctccctcccgcacaaggccccccgcccctccttcacggtgcaccac
cagcccctgcccgggctggccctggcccaggctgcgcccgtgatcccgcaggccagctcc
acggggccgtctgccgtgtgggtttcccttggcatgccgcctccgtatgccgcgcgcctt
gcgggggttaagccgagataa
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