Mustela lutreola (European mink): 131823456 Help Entry 131823456         CDS       T09578                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism mlk  Mustela lutreola (European mink) Pathway mlk04010   MAPK signaling pathway mlk04014   Ras signaling pathway mlk04015   Rap1 signaling pathway mlk04022   cGMP-PKG signaling pathway mlk04066   HIF-1 signaling pathway mlk04068   FoxO signaling pathway mlk04072   Phospholipase D signaling pathway mlk04150   mTOR signaling pathway mlk04151   PI3K-Akt signaling pathway mlk04152   AMPK signaling pathway mlk04211   Longevity regulating pathway mlk04213   Longevity regulating pathway - multiple species mlk04520   Adherens junction mlk04910   Insulin signaling pathway mlk04913   Ovarian steroidogenesis mlk04923   Regulation of lipolysis in adipocytes mlk04930   Type II diabetes mellitus mlk04931   Insulin resistance mlk04932   Non-alcoholic fatty liver disease mlk04960   Aldosterone-regulated sodium reabsorption mlk05010   Alzheimer disease mlk05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mlk00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     131823456 (INSR)    04014 Ras signaling pathway     131823456 (INSR)    04015 Rap1 signaling pathway     131823456 (INSR)    04066 HIF-1 signaling pathway     131823456 (INSR)    04068 FoxO signaling pathway     131823456 (INSR)    04072 Phospholipase D signaling pathway     131823456 (INSR)    04022 cGMP-PKG signaling pathway     131823456 (INSR)    04151 PI3K-Akt signaling pathway     131823456 (INSR)    04152 AMPK signaling pathway     131823456 (INSR)    04150 mTOR signaling pathway     131823456 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     131823456 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     131823456 (INSR)    04923 Regulation of lipolysis in adipocytes     131823456 (INSR)    04913 Ovarian steroidogenesis     131823456 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     131823456 (INSR)   09149 Aging    04211 Longevity regulating pathway     131823456 (INSR)    04213 Longevity regulating pathway - multiple species     131823456 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     131823456 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     131823456 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     131823456 (INSR)    04932 Non-alcoholic fatty liver disease     131823456 (INSR)    04931 Insulin resistance     131823456 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mlk01001]     131823456 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:mlk04090]     131823456 (INSR) Enzymes [BR:mlk01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      131823456 (INSR) Protein kinases [BR:mlk01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    131823456 (INSR) CD molecules [BR:mlk04090]  Proteins   131823456 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  131823456 NCBI-ProteinID:  XP_059015835 LinkDB All DBs Position 2:5984983..6112753 Genome browser AA seq 1381 aa AA seqDB search MGAGAGRGAATAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTSCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTSEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC TVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFEAEGSPKHNQSEHEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRKSSSSPGAEDTRPSRKRRALRDVANVTAAVPTAAGF PNTSTSTPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDAPEERCSVAAYVS ARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVS RRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGP LIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPRE KITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAA EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC PERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEF EDMESVPLDRASHSQREEAGGRDGGSSLGLKRNYEEHIPYTHMNGGKKNGRILTLPRSNP S NT seq 4146 nt NT seq  +upstreamnt  +downstreamnt atgggcgccggggctgggcggggggcggcgaccgcgccgctgctggtggcggtggccgcg ctgctgctgggtgccgcgggccacctgtaccccggagaggtgtgtcccggcatggatatc cggaacaacctcacgaggttgcatgagctggccaactgctcggtcattgaaggacatttg cagatactgttgatgttcaaaacgaggcccgaggatttccgagacctcagtttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacctgttccccaacctcacggtcatccggggctcgcgcctcttcttcaactacgcactg gtcatcttcgagatggttcacctgaaggaactcggcctctatagcttgatgaacattacc cggggctccgtccgcatcgagaaaaataacgagctgtgctacctggccaccatcgactgg tcgcgcatcctggattctgtggaggataattatattgtgctgaacaaagacgacaacgag gagtgtggggacatttgtccgggcacggcgaagggcaagaccagctgccctgccactgtc atcaacgggcagtttgtcgagcggtgttggacacacagccactgccagaaagtctgtccc accatctgcaagtcgcacggctgcacctcggagggcctctgctgccacagcgagtgctta ggcaattgctctgagcccgacgaccccaccaagtgcgtggcctgtcgcaatttctacctg gacggcaggtgcgtggagacctgcccgcccccgtactatcacttccaggactggcgctgc gtgaacttcagcttttgccaggacctgcacaacaaatgcaagaactcccggaggcagggc tgccaccagtacgtcattcacaacaacaagtgcatccccgagtgcccctctggttacacg atgaattccagcaacctgatgtgcactccatgcctgggcccctgtcccaaggtctgccac atcctggaaggcgagaagaccattgactcggtgacgtctgcccaggagcttcgaggctgc acggtggtcaacggaagcctcatcatcaacatccgagggggcaacaacctggcagctgag ctggaggccaacctcggactcattgaggaaatttctgggtatctgaaaatccggagatcc tacgctcttgtgtcactttcctttttccggaagttacggctgattcgaggagagaccttg gaaatcgggaactactctttctacgccttggacaaccagaacctaaggcagctttgggat tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataatcccaaa ctctgcttgtcagaaattcacaagatggaggaagtttcgggaaccaaggggcgccaggag aggaacgacattgccctgaagaccaacggggaccaggcgtcttgtgagaacgaactcctt aaattttcttacattcggacatcgtacgacaagatcttgctaaaatgggagccatactgg ccccctgacttccgagaccttttggggttcatgcttttctacaaagaggccccttaccag aatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggaccgtggtggac attgacccccctctgcggtccaatgaccccaagtcgcagaaccacccagggtggctgatg cggggtctcaagccctggacccagtacgccatttttgtcaagaccttggttaccttttct gatgaacgccgcacgtacggggccaagagtgacatcatctatgtgcagacggatgccact aacccttccgtccccctggatccaatctccgtttctaattcctcgtcccagattatcctg aagtggaaacctccctcggaccccaacggcaatatcacacactacctggttttctgggag aggcaggcggaagacagtgagctgtacgagctggattattgcctcaaagggttgaagctg ccgtcccggacctggtctccgccgttcgaggctgagggctccccgaagcacaaccagagt gaacacgaggagtccgccggcgagtgctgctcctgccccaagacagactcccagatcctc aaggagctggaggagtcctcttttaggaagacctttgaggattacctgcacaatgtggtg ttcgtccccagaaaatcctcgtcaagccctggtgctgaggacactaggccgtcgcggaaa cgcagggccctcagggacgtggccaacgtgacagcggccgtgcccacagctgccggtttc cccaacacctcgactagcacgcccacgagcccggaggagcacaaaccttttgagaaggtg gtaaacaaggagtccctggtcatctctgggctgcgtcatttcaccggctaccgtatcgag ctgcaggcttgcaaccaggacgcccccgaggagaggtgcagcgtggcggcctacgtcagc gccaggaccatgcccgaagccaaggcagacgacatcgtcggccccgtgacccacgaaatc ttcgagaacaatgtcgttcacttgatgtggcaggagccgaaggaacccaacggtctgatt gtgctgtatgaagtcagttaccgacgctatggagatgaggagctgcacctctgtgtctcc cgcagacacttcgctctggagcgcggctgcaggctgcgcgggctgccgccagggaattac agcgtgcgagtccgggccacctccctggcaggcaacggatcctggacagaagccacctat ttctacgtgacagactatttagatgtcccatcgaatattgcaaaaatcatcatcggcccc ctcatctttgtctttctcttcagtgttgtgattggaagtatttacctgttcctgcggaag aggcagccggatgggccgctgggaccgctgtatgcatcttcaaaccctgagtacctcagt gccagtgatgtgttcccatgttctgtgtatgtgccggacgagtgggaggtgcctcgggag aagatcactctcctgcgggagctggggcagggctccttcggcatggtgtacgagggcaac gccagggacatcgtcaagggcgaggcggagacccgcgtggcggtgaagacggtcaacgag tcggccagtctgcgggagaggatcgagtttctcaacgaggcctccgtcatgaagggcttc acctgtcatcacgtggtccgcctcctgggggtggtgtccaaaggccagccgacgctggtg gtgatggagctgatggcccacggagacctcaagagctacctccgctccctgcggccggag gctgagaataaccccggccgccctccccctaccctgcaagagatgattcagatggcagcg gagatcgccgacgggatggcctacctgaatgccaagaagttcgtgcaccgggatcttgca gcccggaactgcatggtggcccacgatttcaccgtcaaaattggagactttgggatgacc agagacatctatgaaacggattactaccggaaaggaggcaagggtctgctccctgtgcgg tggatggcaccggaatccctgaaggacggggtctttaccacttcttctgacatgtggtcc tttggcgtggtcctctgggaaatcaccagcttggcagaacagccttaccaaggcctgtca aatgaacaggtgttgaaatttgtcatggatggagggtatctggaccaacccgacaattgt ccagagagagtcaccgacctgatgcgtatgtgttggcaattcaatcccaagatgcggccc accttcctagagatcgtcgacctgctcaaggacgacctgcaccccagctttccggaagtt tccttcttccacagcgaggagaacaaggcgcctgagagcgaggagctggagatggagttt gaggacatggagagcgtccccctggatcgggcctcccactctcagagggaggaggccggg ggccgggatggagggtcctccctgggcctaaagaggaactacgaggagcacatcccctat acccacatgaatgggggcaagaaaaacggacggattctgactctgccgaggtcgaatcct tcctaa

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