Mirounga leonina (Southern elephant seal): 118005442
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Entry
118005442 CDS
T07472
Symbol
INSR
Name
(RefSeq) insulin receptor isoform X1
KO
K04527
insulin receptor [EC:
2.7.10.1
]
Organism
mlx
Mirounga leonina (Southern elephant seal)
Pathway
mlx04010
MAPK signaling pathway
mlx04014
Ras signaling pathway
mlx04015
Rap1 signaling pathway
mlx04022
cGMP-PKG signaling pathway
mlx04066
HIF-1 signaling pathway
mlx04068
FoxO signaling pathway
mlx04072
Phospholipase D signaling pathway
mlx04150
mTOR signaling pathway
mlx04151
PI3K-Akt signaling pathway
mlx04152
AMPK signaling pathway
mlx04211
Longevity regulating pathway
mlx04213
Longevity regulating pathway - multiple species
mlx04520
Adherens junction
mlx04910
Insulin signaling pathway
mlx04913
Ovarian steroidogenesis
mlx04923
Regulation of lipolysis in adipocytes
mlx04930
Type II diabetes mellitus
mlx04931
Insulin resistance
mlx04932
Non-alcoholic fatty liver disease
mlx04960
Aldosterone-regulated sodium reabsorption
mlx05010
Alzheimer disease
mlx05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
mlx00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
118005442 (INSR)
04014 Ras signaling pathway
118005442 (INSR)
04015 Rap1 signaling pathway
118005442 (INSR)
04066 HIF-1 signaling pathway
118005442 (INSR)
04068 FoxO signaling pathway
118005442 (INSR)
04072 Phospholipase D signaling pathway
118005442 (INSR)
04022 cGMP-PKG signaling pathway
118005442 (INSR)
04151 PI3K-Akt signaling pathway
118005442 (INSR)
04152 AMPK signaling pathway
118005442 (INSR)
04150 mTOR signaling pathway
118005442 (INSR)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04520 Adherens junction
118005442 (INSR)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
118005442 (INSR)
04923 Regulation of lipolysis in adipocytes
118005442 (INSR)
04913 Ovarian steroidogenesis
118005442 (INSR)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
118005442 (INSR)
09149 Aging
04211 Longevity regulating pathway
118005442 (INSR)
04213 Longevity regulating pathway - multiple species
118005442 (INSR)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
118005442 (INSR)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
118005442 (INSR)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
118005442 (INSR)
04932 Non-alcoholic fatty liver disease
118005442 (INSR)
04931 Insulin resistance
118005442 (INSR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mlx01001
]
118005442 (INSR)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
mlx04090
]
118005442 (INSR)
Enzymes [BR:
mlx01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
118005442 (INSR)
Protein kinases [BR:
mlx01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
118005442 (INSR)
CD molecules [BR:
mlx04090
]
Proteins
118005442 (INSR)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Pkinase
Furin-like
Insulin_TMD
fn3
Kinase-like
DUF4476
B2
Motif
Other DBs
NCBI-GeneID:
118005442
NCBI-ProteinID:
XP_034853265
LinkDB
All DBs
Position
Unknown
AA seq
1381 aa
AA seq
DB search
MGTAAGRGAATAPLLVAVAALLLGATGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSQCL
GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNRCKNSRRQG
CHQYVIHNSKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC
TVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE
RQVEDSELYELDYCLKGLKLPSRTWSPPFEAEGSQKHNQSEYEESAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRKSSSSPGAEDTRPSRKRRALGDVANVTAAAPTVPGF
PNTSTSAPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYVS
ARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVS
RRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGP
LIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPRE
KITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF
TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAA
EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR
WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC
PERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEF
EDMESVPLDRASHSQREEAGGRDGGSSLGLKRNYEEHIPYTHMNGGKKNGRILTLPRSNP
S
NT seq
4146 nt
NT seq
+upstream
nt +downstream
nt
atgggcaccgcggctgggcggggggcggcgaccgcgccgctgctggtggcggtggccgcg
ctgctgctgggtgccacgggccacctgtaccccggagaggtgtgccctggcatggatatc
cggaacaacctcacgaggttgcatgagctggccaactgctcagtcattgaaggacatttg
cagatactgttgatgttcaaaacgaggcccgaggatttccgagacctcagtttccccaaa
ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag
gacctgttccccaacctcacggtcatccggggctcgcgtctcttcttcaactatgcgctg
gtcatcttcgagatggttcacctgaaggagcttggcctctacagcttgatgaacattacc
cggggctccgtccgcattgagaagaacaatgagctctgctacctggccaccatcgactgg
tcgcgcatcctggattctgtggaggataattacattgtgctgaacaaagatgacaacgag
gagtgtggggacatttgtccaggcactgcaaagggcaagaccaactgccccgccactgtc
atcaacgggcagtttgtcgagcggtgctggacacacagccactgccagaaagtttgtccc
accatctgcaagtcgcacggctgcaccgctgagggtctctgctgccacagccagtgtttg
ggcaattgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaacttctacctg
gatggcaggtgcgtggagacctgcccgcccccatactaccacttccaagactggcgctgc
gtgaacttcagcttctgtcaggacctgcacaacagatgcaagaactcccggagacagggc
tgccaccaatacgtcattcacaacagcaagtgcatccccgagtgcccctctggctacacg
atgaattccagcaacctgatgtgcactccatgcctgggcccctgtcccaaggtctgtcac
atcctggagggcgagaaaaccattgactcggtgacgtctgcccaggagctccgaggctgc
actgttgtcaacggaagcctcatcatcaacatccgagggggcaacaacctggcagctgag
ctggaggccaacctaggactcattgaagaaatttccgggtatctgaaaatccggagatcc
tacgctcttgtgtcactttcttttttccggaagttacggctgattcgaggagagaccttg
gaaatcgggaactactctttctacgccttggacaaccagaacctaaggcagctctgggac
tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactacaatcccaaa
ctctgcttgtcagaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag
aggaacgacattgccctgaagaccaacggggaccaggcgtcttgtgaaaatgaactcctt
aaattttcttacattcggacatcgtatgacaagatcttgctgaaatgggagccgtactgg
ccccctgacttccgagacctcctggggttcatgcttttctacaaagaggccccttatcag
aatgtgaccgagtttgacgggcaggacgcgtgtggctctaacagctggacggtggtggac
attgacccgcctctgcggtccaatgaccccaagtcgcagaaccacccggggtggctgatg
cggggtctcaagccctggacccagtatgccatcttcgtcaagaccttggtcaccttttcc
gatgaacgccgcacgtatggggccaagagtgacatcatctatgtgcagacagatgccact
aacccttccgtccccctggatccaatctccgtttctaactcctcgtcccagattattctg
aagtggaagcctccctctgatcccaatggcaacatcacacactacctggttttctgggag
aggcaggtagaagacagtgagctgtatgagctggattactgcctcaaagggctgaagctg
ccgtcccggacctggtctccgccgttcgaggccgagggctcccagaagcacaaccagagt
gaatacgaggagtctgccggcgaatgttgctcctgccccaagacggactctcagatcctc
aaggagctggaggagtcctcttttaggaagacctttgaggattacctgcacaatgtggtg
ttcgtccccagaaaatcctcttcaagccctggtgctgaggacactaggccatcgcggaaa
cgccgggccctcggggacgttgccaacgtgacggcggccgcgcccacggttccgggtttc
cccaacacctcgaccagcgcgcccacgagcccggaggagcacaagcccttcgagaaagtg
gtgaacaaagaatccctggtcatctctgggctgcgccacttcactggctatcgcatcgag
ctgcaggcttgcaaccaagactcccccgaggagaggtgcagcgtggcggcctacgtgagc
gccaggaccatgcccgaagccaaggcagatgacattgttggccccgtgacccacgaaatc
tttgagaacaatgtcgttcacctgatgtggcaggagccaaaggaacccaacggtctgatc
gtgctgtatgaagtgagttaccggcgctatggtgatgaggagctgcacctctgtgtctcc
cgcagacattttgctctggagcggggctgcaggctgcgtgggctgccgccggggaattac
agcgtgcgagtccgggccacctccctggcgggcaacggctcgtggacagaagccacctat
ttctacgtgacagactatttagatgtcccgtcgaatattgcaaaaatcatcatcggcccc
ctcatctttgtctttctcttcagtgttgtgattggaagtatttacctgttcctgagaaag
aggcagccggatgggccactgggaccgctgtacgcgtcttcaaaccccgagtacctcagt
gccagtgacgtcttcccatgttctgtgtatgtgccggacgagtgggaggtgcctcgggag
aagatcacgctcctgcgtgagctggggcagggctccttcggcatggtgtacgaaggcaac
gcgagggacattgtcaagggcgaggcggagacccgcgtggcggtgaagacggtcaacgag
tcggccagtttgcgggagaggatcgagtttctcaacgaggcctcagtcatgaagggcttc
acctgtcatcacgtggtccgcctcctgggggtggtgtccaaaggccagccaacgctggtg
gtgatggagctgatggctcacggcgacctgaagagctacctccgctccctgcggccggag
gctgagaataaccctggccgccctccccctaccctgcaagagatgattcagatggcggcg
gagattgccgacgggatggcctacctgaatgccaagaagtttgtgcaccgagatctcgca
gcccgaaactgcatggtcgcccacgatttcactgtcaaaattggagattttgggatgacc
agagacatctatgaaacggattactaccggaaaggaggcaagggtctgctccccgtgcgg
tggatggcaccggaatccctgaaggacggggtcttcaccacttcttctgacatgtggtcc
ttcggcgtggtcctttgggaaatcaccagcttggcagaacagccttaccaaggcctgtct
aatgaacaggtgttgaaatttgtcatggatggagggtatctggatcaacccgacaattgt
ccagagagagtcaccgacctgatgcgaatgtgctggcagttcaatcctaagatgcggccc
accttcctggagatcgtcgacctgctcaaggacgacctgcaccccagctttccagaagtt
tccttcttccacagcgaggagaacaaggcgcctgagagtgaggagctggagatggagttc
gaggacatggagagtgtccccctggatcgggcctcacactctcagagggaggaggccggg
ggccgggatggagggtcctcactgggcctaaagcggaactacgaggagcatatcccctac
acccacatgaacgggggcaagaaaaacggacggatcctgactctgccgaggtcgaatcct
tcctaa
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