Mus musculus (house mouse): 26395
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Entry
26395 CDS
T01002
Symbol
Map2k1, MAPKK1, MEKK1, Mek1, Prkmk1
Name
(RefSeq) mitogen-activated protein kinase kinase 1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu01521
EGFR tyrosine kinase inhibitor resistance
mmu01522
Endocrine resistance
mmu04010
MAPK signaling pathway
mmu04012
ErbB signaling pathway
mmu04014
Ras signaling pathway
mmu04015
Rap1 signaling pathway
mmu04022
cGMP-PKG signaling pathway
mmu04024
cAMP signaling pathway
mmu04062
Chemokine signaling pathway
mmu04066
HIF-1 signaling pathway
mmu04068
FoxO signaling pathway
mmu04071
Sphingolipid signaling pathway
mmu04072
Phospholipase D signaling pathway
mmu04114
Oocyte meiosis
mmu04140
Autophagy - animal
mmu04148
Efferocytosis
mmu04150
mTOR signaling pathway
mmu04151
PI3K-Akt signaling pathway
mmu04210
Apoptosis
mmu04218
Cellular senescence
mmu04270
Vascular smooth muscle contraction
mmu04370
VEGF signaling pathway
mmu04371
Apelin signaling pathway
mmu04380
Osteoclast differentiation
mmu04510
Focal adhesion
mmu04540
Gap junction
mmu04550
Signaling pathways regulating pluripotency of stem cells
mmu04613
Neutrophil extracellular trap formation
mmu04620
Toll-like receptor signaling pathway
mmu04650
Natural killer cell mediated cytotoxicity
mmu04660
T cell receptor signaling pathway
mmu04662
B cell receptor signaling pathway
mmu04664
Fc epsilon RI signaling pathway
mmu04666
Fc gamma R-mediated phagocytosis
mmu04668
TNF signaling pathway
mmu04720
Long-term potentiation
mmu04722
Neurotrophin signaling pathway
mmu04725
Cholinergic synapse
mmu04726
Serotonergic synapse
mmu04730
Long-term depression
mmu04810
Regulation of actin cytoskeleton
mmu04910
Insulin signaling pathway
mmu04912
GnRH signaling pathway
mmu04914
Progesterone-mediated oocyte maturation
mmu04915
Estrogen signaling pathway
mmu04916
Melanogenesis
mmu04917
Prolactin signaling pathway
mmu04919
Thyroid hormone signaling pathway
mmu04921
Oxytocin signaling pathway
mmu04926
Relaxin signaling pathway
mmu04928
Parathyroid hormone synthesis, secretion and action
mmu04929
GnRH secretion
mmu04934
Cushing syndrome
mmu04935
Growth hormone synthesis, secretion and action
mmu05010
Alzheimer disease
mmu05022
Pathways of neurodegeneration - multiple diseases
mmu05034
Alcoholism
mmu05132
Salmonella infection
mmu05135
Yersinia infection
mmu05160
Hepatitis C
mmu05161
Hepatitis B
mmu05163
Human cytomegalovirus infection
mmu05164
Influenza A
mmu05165
Human papillomavirus infection
mmu05166
Human T-cell leukemia virus 1 infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05200
Pathways in cancer
mmu05205
Proteoglycans in cancer
mmu05206
MicroRNAs in cancer
mmu05207
Chemical carcinogenesis - receptor activation
mmu05208
Chemical carcinogenesis - reactive oxygen species
mmu05210
Colorectal cancer
mmu05211
Renal cell carcinoma
mmu05212
Pancreatic cancer
mmu05213
Endometrial cancer
mmu05214
Glioma
mmu05215
Prostate cancer
mmu05216
Thyroid cancer
mmu05218
Melanoma
mmu05219
Bladder cancer
mmu05220
Chronic myeloid leukemia
mmu05221
Acute myeloid leukemia
mmu05223
Non-small cell lung cancer
mmu05224
Breast cancer
mmu05225
Hepatocellular carcinoma
mmu05226
Gastric cancer
mmu05230
Central carbon metabolism in cancer
mmu05231
Choline metabolism in cancer
mmu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
26395 (Map2k1)
04012 ErbB signaling pathway
26395 (Map2k1)
04014 Ras signaling pathway
26395 (Map2k1)
04015 Rap1 signaling pathway
26395 (Map2k1)
04370 VEGF signaling pathway
26395 (Map2k1)
04371 Apelin signaling pathway
26395 (Map2k1)
04668 TNF signaling pathway
26395 (Map2k1)
04066 HIF-1 signaling pathway
26395 (Map2k1)
04068 FoxO signaling pathway
26395 (Map2k1)
04072 Phospholipase D signaling pathway
26395 (Map2k1)
04071 Sphingolipid signaling pathway
26395 (Map2k1)
04024 cAMP signaling pathway
26395 (Map2k1)
04022 cGMP-PKG signaling pathway
26395 (Map2k1)
04151 PI3K-Akt signaling pathway
26395 (Map2k1)
04150 mTOR signaling pathway
26395 (Map2k1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
26395 (Map2k1)
04148 Efferocytosis
26395 (Map2k1)
09143 Cell growth and death
04114 Oocyte meiosis
26395 (Map2k1)
04210 Apoptosis
26395 (Map2k1)
04218 Cellular senescence
26395 (Map2k1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
26395 (Map2k1)
04540 Gap junction
26395 (Map2k1)
04550 Signaling pathways regulating pluripotency of stem cells
26395 (Map2k1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
26395 (Map2k1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
26395 (Map2k1)
04620 Toll-like receptor signaling pathway
26395 (Map2k1)
04650 Natural killer cell mediated cytotoxicity
26395 (Map2k1)
04660 T cell receptor signaling pathway
26395 (Map2k1)
04662 B cell receptor signaling pathway
26395 (Map2k1)
04664 Fc epsilon RI signaling pathway
26395 (Map2k1)
04666 Fc gamma R-mediated phagocytosis
26395 (Map2k1)
04062 Chemokine signaling pathway
26395 (Map2k1)
09152 Endocrine system
04910 Insulin signaling pathway
26395 (Map2k1)
04929 GnRH secretion
26395 (Map2k1)
04912 GnRH signaling pathway
26395 (Map2k1)
04915 Estrogen signaling pathway
26395 (Map2k1)
04914 Progesterone-mediated oocyte maturation
26395 (Map2k1)
04917 Prolactin signaling pathway
26395 (Map2k1)
04921 Oxytocin signaling pathway
26395 (Map2k1)
04926 Relaxin signaling pathway
26395 (Map2k1)
04935 Growth hormone synthesis, secretion and action
26395 (Map2k1)
04919 Thyroid hormone signaling pathway
26395 (Map2k1)
04928 Parathyroid hormone synthesis, secretion and action
26395 (Map2k1)
04916 Melanogenesis
26395 (Map2k1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
26395 (Map2k1)
09156 Nervous system
04725 Cholinergic synapse
26395 (Map2k1)
04726 Serotonergic synapse
26395 (Map2k1)
04720 Long-term potentiation
26395 (Map2k1)
04730 Long-term depression
26395 (Map2k1)
04722 Neurotrophin signaling pathway
26395 (Map2k1)
09158 Development and regeneration
04380 Osteoclast differentiation
26395 (Map2k1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
26395 (Map2k1)
05206 MicroRNAs in cancer
26395 (Map2k1)
05205 Proteoglycans in cancer
26395 (Map2k1)
05207 Chemical carcinogenesis - receptor activation
26395 (Map2k1)
05208 Chemical carcinogenesis - reactive oxygen species
26395 (Map2k1)
05230 Central carbon metabolism in cancer
26395 (Map2k1)
05231 Choline metabolism in cancer
26395 (Map2k1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
26395 (Map2k1)
09162 Cancer: specific types
05210 Colorectal cancer
26395 (Map2k1)
05212 Pancreatic cancer
26395 (Map2k1)
05225 Hepatocellular carcinoma
26395 (Map2k1)
05226 Gastric cancer
26395 (Map2k1)
05214 Glioma
26395 (Map2k1)
05216 Thyroid cancer
26395 (Map2k1)
05221 Acute myeloid leukemia
26395 (Map2k1)
05220 Chronic myeloid leukemia
26395 (Map2k1)
05218 Melanoma
26395 (Map2k1)
05211 Renal cell carcinoma
26395 (Map2k1)
05219 Bladder cancer
26395 (Map2k1)
05215 Prostate cancer
26395 (Map2k1)
05213 Endometrial cancer
26395 (Map2k1)
05224 Breast cancer
26395 (Map2k1)
05223 Non-small cell lung cancer
26395 (Map2k1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
26395 (Map2k1)
05170 Human immunodeficiency virus 1 infection
26395 (Map2k1)
05161 Hepatitis B
26395 (Map2k1)
05160 Hepatitis C
26395 (Map2k1)
05164 Influenza A
26395 (Map2k1)
05163 Human cytomegalovirus infection
26395 (Map2k1)
05167 Kaposi sarcoma-associated herpesvirus infection
26395 (Map2k1)
05165 Human papillomavirus infection
26395 (Map2k1)
09171 Infectious disease: bacterial
05132 Salmonella infection
26395 (Map2k1)
05135 Yersinia infection
26395 (Map2k1)
09164 Neurodegenerative disease
05010 Alzheimer disease
26395 (Map2k1)
05022 Pathways of neurodegeneration - multiple diseases
26395 (Map2k1)
09165 Substance dependence
05034 Alcoholism
26395 (Map2k1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
26395 (Map2k1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
26395 (Map2k1)
01522 Endocrine resistance
26395 (Map2k1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
26395 (Map2k1)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
26395 (Map2k1)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: STE group
STE7 family
26395 (Map2k1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Seadorna_VP7
Kinase-like
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
26395
NCBI-ProteinID:
NP_032953
MGI:
1346866
Ensembl:
ENSMUSG00000004936
UniProt:
P31938
Q3TMJ8
LinkDB
All DBs
Position
9:complement(64093066..64160887)
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgatggctcggcggtt
aacgggaccagctcggccgagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgacgagcagcagcggaagcggctcgaggcctttctgacgcagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagcgaactgggagctggcaacggtgga
gtggtcttcaaggtctcccacaagccatctggcctggttatggctagaaagctgatccac
ctggagatcaaacccgcaatccggaaccagatcatccgggagctgcaggtactgcacgag
tgcaactccccgtacatcgtgggcttctacggggccttctacagcgacggcgagatcagc
atctgcatggagcacatggatggtgggtccttggatcaagttctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtgataaaaggcctgacctatctt
cgggagaagcacaagattatgcacagagatgtcaagccatccaacattctagtgaactca
cgtggggagatcaaactctgtgattttggggtcagcgggcagctaattgactctatggcc
aactccttcgtgggcacgagatcctacatgtcgcctgagagactccaggggactcactac
tctgtgcagtcggacatctggagcatggggctctctctggtggagatggcagttgggaga
taccccattcctcctcctgatgccaaggagctggagctactgtttggatgccatgtggaa
ggagacgcagccgaaacaccacccaggccaaggacccctgggaggcctctcagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacattgtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggagtttcaggattttgtgaataaa
tgcttaataaagaaccctgcagagagagcagatctgaagcagctcatggtacatgctttc
atcaaaagatctgacgccgaggaggtagacttcgcaggctggctctgctccaccattggg
cttaaccagcccagcacaccaacccacgctgccagcatctga
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