KEGG T07238: 105874387

Microcebus murinus (gray mouse lemur): 105874387

Entry

105874387         CDS       T07238

Name

(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase

K00512

steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]

Organism

mmur Microcebus murinus (gray mouse lemur)

Pathway

mmur00140

Steroid hormone biosynthesis

mmur01100

Metabolic pathways

mmur04913

Ovarian steroidogenesis

mmur04917

Prolactin signaling pathway

mmur04927

Cortisol synthesis and secretion

mmur04934

Cushing syndrome

Module

mmur_M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

mmur_M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

mmur_M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Brite

KEGG Orthology (KO) [BR:mmur00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    105874387
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    105874387
   04917 Prolactin signaling pathway
    105874387
   04927 Cortisol synthesis and secretion
    105874387
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105874387
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:mmur00199]
    105874387
Enzymes [BR:mmur01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     105874387
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     105874387
Cytochrome P450 [BR:mmur00199]
Cytochrome P450, animal type
  CYP17 family
   105874387

SSDB

Motif

Pfam:

p450

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

Ensembl:

VGNC:

UniProt:

LinkDB

Position

15:complement(52377042..52383177)

AA seq 508 aa
MWELVALLLLTLAYFFWPKVRCPGAKYPKSLPSLPLVGSLPFLPRHGHQHVKFFKLQKKY
GPIYSVRMGSKTLVVVGHYQLAKEVLVKKGKDFSGRPHVASLDILSDNGKGIAFADAGSH
WQLHRKLVLATFALFKDGNQKLEKIICQEIGVLCDVLVTYEGQSIDISVPIFLAITNIIC
LICFNNSYKYGDPELTVIQKYNEGILENLGSGSLVDIFPWLQIFPNKSMEMLRKCVKMRN
GLLNGIMEKYKERFRSTSTTNMLDVMIQAKMNSDNNNSDLDQDSKKLSDKHILATVGDIF
GAGVETTVSVIKWIVAFLLHNPQLKKKIHEEIDQNIGFSRTPTISDRSNLIMLEATIREV
LRIRPVAPLLIPHKANIDSSIGEFAIDKGTEIVINLWALHHNEKEWHQPDQFLPERFLDS
TGSQLISPSLSYLPFGAGPRSCVGEVLARQELFLFMSWLLQRFELDVPDDGQLPSLEGKP
KLVFLIEPFKVKMKVRQAWREAQAEAST

NT seq 1527 nt +upstreamnt +downstreamnt
atgtgggagctcgtggctctcttgctgctcaccctagcctatttcttttggcccaaggta
aggtgccctggtgccaagtatcccaagagcctgccgtctctgcccctggtgggcagcctg
ccgttcctccccagacatggccatcaacatgtcaaattcttcaagctgcagaaaaaatac
ggccccatctattctgttcgtatgggttccaagactctagtggttgtcggccactaccag
ctggccaaggaggtgcttgttaagaagggcaaggatttctctgggcggccccatgtggcc
tccctagacatcctgtcggacaatggaaagggcatcgccttcgctgacgctggttcccac
tggcagctgcatcggaagctggtgctggccacctttgccctgttcaaggacggcaaccag
aaactggagaagatcatatgtcaggaaatcggtgtattgtgtgatgtgctggtcacctac
gagggacagtccatagatatttccgtgcctatcttcctggcgataaccaacataatctgc
ttgatctgcttcaacaactcctacaagtacggggaccccgagttgacagtgatacagaag
tataacgagggcatcctggagaatctgggcagcggcagtctggtggacatattcccctgg
ctgcagattttccctaacaaaagcatggaaatgttgaggaagtgtgttaagatgagaaat
ggtctgctgaatggaataatggaaaaatataaggagagattcaggagcacctctaccacc
aacatgctggacgttatgatccaagccaagatgaattcagataataacaacagtgacctg
gaccaggattcaaagaagctttcagataaacacattcttgccacagtaggggacatcttt
ggggccggtgtggagaccactgtctcagtgataaagtggattgtggccttcctgctgcac
aatcctcagttaaagaagaagatccatgaggagattgaccagaatataggtttcagccgt
acaccaaccatcagcgaccggagcaatctcatcatgctggaggccaccatccgagaggtg
cttcgcatcaggcccgtggcccctctgctcatcccccacaaggctaacattgactccagc
attggcgagtttgccattgacaagggcacggagattgtcatcaatctgtgggcattgcat
cacaatgagaaggagtggcaccagccagaccagttcctacctgagcgcttcttggattca
acggggagccagctcatctcaccatcgttgagctacttgcccttcggagcgggcccccgc
tcctgtgtgggtgaagtcctggcccgccaggagctcttcctcttcatgtcctggttgctg
cagaggttcgagctggacgtgccagatgatgggcagctgccctccctggaaggcaaaccc
aagttggtctttctgatcgagcctttcaaagtgaagatgaaggtgcgccaggcctggagg
gaagcccaagctgaggctagcacctaa

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