Mycobacterium noviomagense: MNVI_23210
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Entry
MNVI_23210 CDS
T06809
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mnv
Mycobacterium noviomagense
Pathway
mnv00860
Porphyrin metabolism
mnv01100
Metabolic pathways
mnv01110
Biosynthesis of secondary metabolites
mnv01120
Microbial metabolism in diverse environments
mnv01240
Biosynthesis of cofactors
Module
mnv_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mnv_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mnv00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MNVI_23210 (hemD)
Enzymes [BR:
mnv01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MNVI_23210 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MNVI_23210 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
BBY07003
UniProt:
A0A7I7PEG7
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All DBs
Position
2500716..2502281
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AA seq
521 aa
AA seq
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MTTRAASVLANAALVFTDADVPEAVQAMIGTELPPVSGPAPADAAGATESEAPTAVVSVG
PDIRPALGEPAEVAKTLIAEARSGADVVRLVSGDPLEVDAVISEVNAVARAHLQFEIVPG
LAASAAVPTYAGLPLGSSHTVADVRGDVDWAALAAAPGPLILQATASHLTDAARTLIDYG
LAESTPCVVTAAGTTCTQRSVETTLHALTDGAVLGGADPAGPLTGPLVATIGKTVANRAK
LNWWESRALYGWTVLVPRTKDQAGEMSERLASYGALPIEVPTIAVEPPRSPAQMERAVKG
LVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGEATADRVRAFGVSPELV
PSGEQSSLGLLDEFPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVR
AAPPPAETREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGL
RVDVQPETAAVGPLVDALAEHAARLRAEGALPPPRKKSRRR
NT seq
1566 nt
NT seq
+upstream
nt +downstream
nt
ttgacgacgcgggcggccagcgtgctggccaacgccgccctggtgttcactgacgccgac
gtgccggaggcggtacaggcgatgatcggcaccgagctgccgccggtgtccgggccggcg
ccggccgacgccgcaggggccaccgagtccgaggccccgacggcggtcgtgtcggtcgga
cccgacatccggcccgcgctgggtgaacccgccgaggtagccaagacgttgatcgccgag
gcccgttccggagccgacgtggtgcggctggtcagcggtgatccgctggaagtcgatgcg
gtgatcagcgaggtcaacgccgtggcacgggcgcatctgcagttcgagatcgtgcccggg
ctggccgccagcgccgcggtgccgacgtacgcgggcctgccgttgggctcgtcgcacacc
gtcgccgacgtgcgcggcgacgtggactgggcggcgctggccgccgccccggggccgctg
atcctgcaagccaccgcctcgcacctgaccgacgcggcgcgcaccctgatcgactacggg
ctggccgaatcgacgccgtgcgtcgtcaccgcagccggcaccacctgcacccagcgctcg
gtggagaccacgctgcatgcgctgaccgacggggccgttctgggcggcgccgatccggcc
gggccgctgaccggcccgctggtcgcgacgatcggcaagaccgtcgccaaccgcgccaag
ctcaactggtgggaaagccgcgccctgtacggctggacggtgctggtgccccggaccaaa
gaccaggccggcgagatgagcgaacggctggcgtcctacggcgcgctgccgatcgaggtg
ccgaccatcgcggtcgagccgccgcgcagccccgcgcagatggaacgggcggtcaagggc
ctggtcgacggccgcttccagtgggtggtgttcacctccaccaacgccgtgcgcgcggtg
tgggagaagttcggcgaattcgggctcgacgcccgcgcgttctccggggtgaagatcgcc
tgcgtgggcgaggccaccgccgaccgggtccgcgcgttcggggtcagccccgagctggtg
ccctcgggcgagcagtcgtcgctgggcctgctcgacgaattcccgccgtacgacagcgtt
ttcgacccggtgaaccgggtattgctgccgcgtgccgacatcgccaccgagacactggcc
gagggactgcgggaacgcggctgggagatcgaggacgtcaccgcgtatcgcaccgtgcgg
gctgcgccgccgccggcggagacccgcgaaatgatcaagaccggtggtttcgacgcggtg
tgcttcacgtcgagttcgaccgtgcgcaacctggtcgggatcgccggcaagccgcacgcg
cggaccatcgtcgcctgcatcggacccaagacggccgaaaccgccgcggagttcggcctg
cgggtcgacgtgcagccggagaccgccgcggtgggtcccttggtcgatgcgctggccgag
catgccgcccggctgcgcgccgagggcgcgctgccaccgccacgtaagaagagccgcagg
cgctag
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