Mycolicibacterium psychrotolerans: MPSYJ_02350
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Entry
MPSYJ_02350 CDS
T07008
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mpsc
Mycolicibacterium psychrotolerans
Pathway
mpsc00860
Porphyrin metabolism
mpsc01100
Metabolic pathways
mpsc01110
Biosynthesis of secondary metabolites
mpsc01120
Microbial metabolism in diverse environments
mpsc01240
Biosynthesis of cofactors
Module
mpsc_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mpsc_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mpsc00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MPSYJ_02350 (hemD)
Enzymes [BR:
mpsc01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MPSYJ_02350 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MPSYJ_02350 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBX66774
UniProt:
A0A7I7M3N5
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All DBs
Position
complement(235119..236789)
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AA seq
556 aa
AA seq
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MTLRGRKGKPGRITFVGSGPGDPGLLTTRARAVLANAALVFTDPDVPEAVLALAGSELPP
PSGPVPAAGAAEAAATDAAPAEAAEPVIPGGPDIRPALGDPAEVAKTLATEARTGVDVVR
LVAGDPLSIDAVITEINALARTQLAFEIVPGLPDTSAVPTYAGLPLGSSHTVADVRDPNV
DWAALAAAPGPLILHATASHLPEAARTLIEYGLAENTPAVVTANGTTCQQRSVETTLAGL
LDKAVLDKPAGVEPSGPLTGTLVVTIGRTVANRAKLNWWESRALYGWTVLVPRTKDQAGE
MSERLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFN
EFGLDARAFSGVKIACVGQATADRVRAFGINPELVPTGEQSSLGLLDEFPPYDDVFDPVN
RVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQTREMIKTGGFDAVCFTSS
STVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHAARL
RAEGALPPPRKKSRRR
NT seq
1671 nt
NT seq
+upstream
nt +downstream
nt
atgaccttgcgaggacgcaagggcaagcccggccgcatcacgttcgtcggctccgggccc
ggggatccgggcctgctgacgacgcgcgcccgagctgtattggccaacgccgccctcgtc
ttcaccgaccctgacgtgccggaagcggtgctcgccctggcgggttccgagctgccgccg
ccgtcgggaccggttccggcggccggcgccgcggaggctgcggccaccgacgccgcgccc
gcggaggcggccgaacccgtcatccccggcggcccggacatccggcccgcgctcggtgac
ccggccgaggtcgccaagacgctggccaccgaggcccgcaccggagtcgacgtggttcgc
ctggtggccggtgacccgctgtcgatcgacgcggtgatcaccgagatcaacgcgctggca
cggacccagctggccttcgagatcgttcccggtctgcccgacacgtcggccgtgccgacc
tatgcgggactgccgctggggtcgtcgcacaccgtcgccgacgtccgcgacccgaacgtg
gactgggccgcgctggccgccgcgcccggaccgctgatcctgcacgcgaccgcgtcgcat
ctgcccgaggccgcgcgcacgctgatcgagtacgggctcgccgagaacacccccgccgtc
gtcaccgccaacggcaccacgtgccagcagcgttcggtggagaccacgctggcgggtctg
ctggacaaggcggtgctggacaagcccgccggtgtcgagccgtccggcccgctgaccggc
acgctggtcgtgaccatcggccggaccgtggccaatcgggccaagctgaactggtgggag
agccgcgcactgtacggctggaccgtgctggtgccgcgcaccaaggaccaggcgggcgag
atgagcgagcggctcgtcggccacggcgcgctgcccatcgaggtgccgaccatcgcggtc
gagccgccccgcagcccggcccagatggaaagggctgtcaagggtctggtcgacggccgg
ttccagtgggtggtgttcacctccaccaacgcggtgcgtgcggtgtgggagaagttcaac
gagttcgggctcgacgcccgcgcgttctccggcgtcaagatcgcctgcgtggggcaggcc
accgccgaccgggtgcgcgccttcgggatcaacccggagctggtgcccaccggtgagcag
tcctctctcggcctgctcgacgaattcccgccctacgacgacgttttcgacccggtcaac
cgggtgctgctgccgcgcgccgacatcgccaccgagacgctcgccgaagggctgcgcgag
cgtgggtgggagatcgaggatgtcaccgcctaccggaccgtgcgcgcggcgccgccgccg
gcgcagacccgcgagatgatcaagacgggcggcttcgacgcggtgtgcttcacgtcgagc
tccacggtgcgcaacctcgtcggcatcgcaggcaagccgcacgcgcgcacgatcgtcgcg
tgcatcggaccgaaaaccgctgagaccgcagctgaattcgggttgcgcgtcgatgtccag
cccgaggtggccgcggtggggccgctcgtcgaggcgctcgccgagcacgccgcccggctg
cgtgccgagggtgcgttgcccccgccgcggaagaagagccgccgccgctga
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