Mycobacterium tuberculosis H37Ra: MRA_3017
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Entry
MRA_3017 CDS
T00540
Symbol
leuC
Name
(GenBank) isopropylmalate isomerase large subunit
KO
K01703
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:
4.2.1.33
4.2.1.35
]
Organism
mra
Mycobacterium tuberculosis H37Ra
Pathway
mra00290
Valine, leucine and isoleucine biosynthesis
mra00660
C5-Branched dibasic acid metabolism
mra01100
Metabolic pathways
mra01110
Biosynthesis of secondary metabolites
mra01210
2-Oxocarboxylic acid metabolism
mra01230
Biosynthesis of amino acids
Module
mra_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
mra00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00660 C5-Branched dibasic acid metabolism
MRA_3017 (leuC)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
MRA_3017 (leuC)
Enzymes [BR:
mra01000
]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.33 3-isopropylmalate dehydratase
MRA_3017 (leuC)
4.2.1.35 (R)-2-methylmalate dehydratase
MRA_3017 (leuC)
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Gene cluster
GFIT
Motif
Pfam:
Aconitase
AcnX
Motif
Other DBs
NCBI-ProteinID:
ABQ74799
UniProt:
A5U6Z9
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All DBs
Position
complement(3356823..3358244)
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AA seq
473 aa
AA seq
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MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRR
PELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGP
QLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGR
LPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMV
APDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTN
PGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMRDIAVDAVFVGSCTNGRIE
DLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGM
NPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN
NT seq
1422 nt
NT seq
+upstream
nt +downstream
nt
atggccttgcagaccggcgagccacgcacactggccgagaagatttgggacgaccacatt
gtggtatcaggcgggggctgtgcgcccgacttgatctacatcgatctgcatctggtgcat
gaggtcaccagcccgcaggcgttcgacggcctgcgcctggccgggcgccgggtgcggcgg
cccgagctcaccctcgccaccgaggatcacaacgtgcccaccgtcgacatcgaccagccg
atcgccgacccggtgtcacgcacccaggtggagacgttgcgccgaaactgcgccgaattc
ggaatccggctgcattcaatgggcgatatcgagcagggcatcgtgcacgtcgtcggaccg
caattgggtctcacccagccgggaatgacgatcgtctgtggcgatagccacacctcaacc
cacggcgcattcggcgcgttggcgatgggcatcggtacgtcggaggtcgagcacgtgctg
gccacccagacgctgccgctgcggccgttcaagaccatggcggtcaacgtcgatgggcgg
ctgcccgacggtgtgtcggccaaggacatcatcctggcgttgatcgccaagatcggcacc
ggcggcggccaggggcatgtcatcgaataccggggcagcgccatcgaatcgctgtccatg
gaaggccggatgacgatctgcaacatgagcatcgaagccggcgctcgtgcgggcatggtg
gctccggacgaaaccacctacgcgttcttgcgtggtcgtccgcacgcacccaccggtgcc
cagtgggacaccgcactcgtctactggcaacggcttcgcaccgacgtcggcgccgttttc
gacaccgaggtgtatctcgacgccgcgtcgttgagcccgtttgtcacctggggcaccaac
ccaggccaaggggtaccgctggcggccgcggtgccagatccgcaactgatgaccgacgac
gccgagcggcaggccgccgagaaagcattggcgtacatggaccttcgacccggaaccgcg
atgcgcgacatcgcggtcgacgccgtgttcgtcgggtcgtgtaccaacggtcgcattgaa
gatctgcgggtggtcgccgaagtgctgcgtggccgcaaggtggccgacggcgtgcggatg
ctgatcgttccgggctcaatgcgggtacgcgcgcaggccgaggccgaagggctcggtgag
atcttcaccgacgcgggcgcgcaatggcggcaggcgggatgctcgatgtgtctgggcatg
aatcccgatcagctggcgtccggggagcgctgcgccgcgacgtccaaccgcaacttcgaa
gggcggcagggcgcgggcggccgcacacatttggtgtccccagcagtggcggccgccacc
gcggttcgcggcacactgtccagcccggccgatttgaattga
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