KEGG   PATHWAY: mrm03070
Entry
mrm03070                    Pathway                                
Name
Bacterial secretion system - Minicystis rosea
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
mrm03070  Bacterial secretion system
mrm03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Minicystis rosea [GN:mrm]
Gene
A7982_03570  outer membrane efflux protein [KO:K12340]
A7982_05610  outer membrane efflux protein [KO:K12340]
A7982_07432  General secretion pathway protein D [KO:K02453]
A7982_13928  General secretion pathway protein D / Type II secretion outermembrane pore forming protein (PulD) [KO:K02453]
A7982_07434  General secretion pathway protein C [KO:K02452]
A7982_10133  General secretion pathway protein C [KO:K02452]
A7982_07430  Type IV fimbrial assembly protein PilC [KO:K02455]
A7982_10903  Hypothetical protein [KO:K02456]
A7982_07428  Hypothetical protein [KO:K02456]
A7982_07429  Hypothetical protein [KO:K02456]
A7982_07427  General secretion pathway protein H [KO:K02457]
A7982_07425  General secretion pathway protein J [KO:K02459]
A7982_07424  Hypothetical protein [KO:K02460]
A7982_07423  General secretion pathway protein L [KO:K02461]
A7982_04007  Type IV fimbrial assembly, ATPase PilB [KO:K02454] [EC:7.4.2.8]
A7982_07431  General secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
A7982_02220  Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [KO:K02454] [EC:7.4.2.8]
A7982_01278  Protein-export membrane protein SecD [KO:K03072]
A7982_05074  Protein-export membrane protein SecD [KO:K03072]
A7982_11754  Protein-export membrane protein SecF [KO:K03074]
A7982_05073  Protein-export membrane protein SecF [KO:K03074]
A7982_11229  Preprotein translocase subunit SecE [KO:K03073]
A7982_07489  Preprotein translocase subunit SecG [KO:K03075]
A7982_09504  Preprotein translocase secY subunit [KO:K03076]
A7982_07146  Preprotein translocase secY subunit [KO:K03076]
A7982_05075  Hypothetical protein [KO:K03210]
A7982_04920  Inner membrane protein translocase component YidC, long form [KO:K03217]
A7982_10650  hypothetical protein [KO:K03070] [EC:7.4.2.8]
A7982_03449  Signal recognition particle receptor protein FtsY [KO:K03110]
A7982_08870  Signal recognition particle, subunit Ffh SRP54 [KO:K03106] [EC:3.6.5.4]
A7982_07809  Hypothetical protein [KO:K03116]
A7982_03203  Twin-arginine translocation protein TatC [KO:K03118]
A7982_01380  VgrG protein [KO:K11904]
A7982_04021  VgrG protein [KO:K11904]
A7982_05769  Putative vgr related protein [KO:K11904]
A7982_05770  Hypothetical protein [KO:K11904]
A7982_06660  Hypothetical protein [KO:K11904]
A7982_06662  VgrG protein [KO:K11904]
A7982_02671  VgrG protein [KO:K11904]
A7982_02711  VgrG protein [KO:K11904]
A7982_11959  VgrG protein [KO:K11904]
A7982_12832  Rhs element Vgr protein [KO:K11904]
A7982_02304  Hypothetical protein [KO:K11904]
A7982_07693  VgrG protein [KO:K11904]
A7982_13265  Putative VGR-related protein [KO:K11904]
A7982_13267  Putative vgr related protein [KO:K11904]
A7982_13268  Putative vgr related protein [KO:K11904]
A7982_09448  VgrG protein [KO:K11904]
A7982_12009  Rhs element Vgr protein [KO:K11904]
A7982_12863  Putative vgr related protein [KO:K11904]
A7982_13712  hypothetical protein [KO:K11904]
A7982_01975  VgrG protein [KO:K11904]
A7982_05520  VgrG protein [KO:K11904]
A7982_04660  Hypothetical protein [KO:K11904]
A7982_05572  VgrG protein [KO:K11904]
A7982_13782  VgrG protein [KO:K11904]
A7982_12538  VgrG protein [KO:K11904]
A7982_13399  Putative vgr related protein [KO:K11904]
A7982_13400  VgrG protein [KO:K11904]
A7982_13401  Rhs element Vgr protein [KO:K11904]
A7982_02984  VgrG protein [KO:K11904]
A7982_03857  VgrG protein [KO:K11904]
A7982_03858  VgrG protein [KO:K11904]
A7982_03859  VgrG protein [KO:K11904]
A7982_12687  Rhs element Vgr protein [KO:K11904]
A7982_13531  VgrG protein [KO:K11904]
A7982_03650  Hypothetical protein [KO:K11904]
A7982_04501  VgrG protein [KO:K11904]
A7982_04502  Rhs element Vgr family protein [KO:K11904]
A7982_11583  VgrG protein [KO:K11904]
A7982_11589  VgrG protein [KO:K11904]
A7982_01317  Rhs element Vgr family protein [KO:K11904]
A7982_00471  VgrG protein [KO:K11904]
A7982_09640  VgrG protein [KO:K11904]
A7982_06015  Hypothetical protein [KO:K11904]
A7982_06019  Rhs element Vgr family protein [KO:K11904]
A7982_06020  Hypothetical protein [KO:K11904]
A7982_02438  Hypothetical protein [KO:K11904]
A7982_11319  VgrG protein [KO:K11904]
A7982_12207  Putative vgr related protein [KO:K11904]
A7982_12208  VgrG protein [KO:K11904]
A7982_12209  PE family protein [KO:K11904]
A7982_13887  VgrG protein [KO:K11904]
A7982_12107  VgrG protein [KO:K11904]
A7982_12985  VgrG protein [KO:K11904]
A7982_11469  VgrG protein [KO:K11904]
A7982_02580  VgrG protein [KO:K11904]
A7982_07139  Hypothetical protein [KO:K11904]
A7982_07961  Hypothetical protein [KO:K11904]
A7982_12293  VgrG protein [KO:K11904]
A7982_04503  Putative vgr related protein [KO:K11904]
A7982_00628  VgrG protein [KO:K11904]
A7982_05869  Hypothetical protein [KO:K11903]
A7982_06787  Secreted protein Hcp [KO:K11903]
A7982_06788  secreted protein Hcp [KO:K11903]
A7982_05576  Hypothetical protein [KO:K11903]
A7982_06779  Type VI secretion lipoprotein/VasD [KO:K11906]
A7982_06775  IcmF-related protein [KO:K11891]
A7982_05580  IcmF-related protein [KO:K11891]
A7982_08400  IcmF-related protein [KO:K11891]
A7982_10673  Hypothetical protein [KO:K11892]
A7982_06776  Putative transmembrane protein [KO:K11892]
A7982_05581  Hypothetical protein [KO:K11892]
A7982_06780  ClpB protein [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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