Micromonospora sagamiensis: GCM10017556_18990
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Entry
GCM10017556_18990 CDS
T06946
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
msag
Micromonospora sagamiensis
Pathway
msag00860
Porphyrin metabolism
msag01100
Metabolic pathways
msag01110
Biosynthesis of secondary metabolites
msag01120
Microbial metabolism in diverse environments
msag01240
Biosynthesis of cofactors
Module
msag_M00121
Heme biosynthesis, plants and bacteria, glutamate => heme
msag_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
msag_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
msag00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
GCM10017556_18990 (hemD)
Enzymes [BR:
msag01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
GCM10017556_18990 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
GCM10017556_18990 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
BCL14160
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Position
complement(2241343..2242812)
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AA seq
489 aa
AA seq
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MVYDRGVPESLLDAVRAQARSDAQFTPAEGAPGDVAKVLISAARSGLNAVHLVAGDPFGH
ESVVKEVQAVARTAAHFEVVPGVSQAEGVATYAGVPLPGVRTSADVEDVTTLDFEALAAA
IGRGSLALAVDAGDLAAIRDGLLAVGVDGTTAVGVTGDGTGETQYTTTSTVDSFVAAALG
FTGRVVLTLGESVGQRDRLSWWENRPLYGWKVLVPRTKEQAGVMSARLRAYGAIPCEVPT
IAVEPPRTPAQMERAVKGLVDGRYAWVIFTSVNAVRAVWEKFAEHGLDARHFGGVKIACI
GEATADAVRAFGIQPELIPAGEQSSEGLLAEFSPHDEILDPVGRVLLPRADIATETLAAG
LTERGWEVDDVTAYRTVRAAPPPAEIRDAIKSGGFDAVLFTSSSTVRNLVGIAGKPHART
VVAVIGPKTAETATEFGLRVDVQPAHASVPDLVEALATYAVELREKLAAMPAKQRRGSKV
QGPTALRFR
NT seq
1470 nt
NT seq
+upstream
nt +downstream
nt
gtggtgtacgaccggggcgtacccgagtcgctgctcgacgccgtccgcgcccaggcccgc
tccgacgcccagttcactccggcggagggcgcgcccggtgacgtggcgaaggtgctcatc
tcggcggcccgttccgggctgaacgcggtgcacctggtcgccggtgacccgttcgggcac
gagtcggtggtcaaggaggtgcaggcggtggcgcgtacggccgcgcacttcgaggtggtg
cccggcgtgagtcaggccgagggtgtcgccacctacgccggggtgccgctgcccggcgtc
cggacctccgccgacgtcgaggacgtcaccacgctggacttcgaggcgctcgccgccgcc
atcggccggggttcgctggcactggccgtggacgcgggcgacctcgccgcgatccgggac
ggcctgctcgccgtcggggtggacggcaccaccgcggtcggggtgaccggggacggcacc
ggggagacccagtacaccaccacgtcgaccgtggactccttcgtcgccgccgcgctcggc
ttcaccggccgggtcgtgctcaccctcggggagagcgtcggccagcgcgaccggctcagc
tggtgggagaaccgcccgctgtacggctggaaggtgctggtcccccggactaaggagcag
gccggcgtgatgagcgcgcggctgcgcgcgtacggggcgatcccgtgcgaggtgccgacc
atcgcggtcgagccgccgcgtacccccgcccagatggagcgggcggtcaagggcctggtc
gacggccggtacgcgtgggtgatcttcacctcggtcaacgccgtgcgggcggtatgggag
aagttcgccgagcacggcctggacgcccggcacttcggcggcgtcaagatcgcctgtatc
ggcgaggcgaccgccgacgcggtccgcgcgttcggcatccagccggagctgatcccggcc
ggggagcagtcctccgaggggctgctggccgagttctccccgcacgacgagatcctcgac
ccggtgggccgggtgctgctgccgcgcgccgacatcgccaccgagacgctcgccgccggg
ctcaccgagcgcggctgggaggtcgacgacgtgaccgcgtaccggacggtccgggccgcg
ccgccgcccgccgagatccgggacgcgatcaagtcgggtggcttcgacgcggtcctcttc
acgtcgtcctcgacggtgcgcaacctggtcggcatcgccggcaagccgcacgcgcgtacc
gttgtcgccgtgatcggtcccaagacggccgagacggcgaccgagttcggcctccgggtc
gacgtgcagccggcgcacgcttcggtgccggacctggtcgaggcgctcgccacctacgcc
gtcgagttgcgggagaagctggccgcgatgccggccaagcagcgccgcggctcgaaggtg
caggggccgaccgccctgcggttccgctag
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