Mycobacterium saskatchewanense: MSAS_42390
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Entry
MSAS_42390 CDS
T07413
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
msak
Mycobacterium saskatchewanense
Pathway
msak00860
Porphyrin metabolism
msak01100
Metabolic pathways
msak01110
Biosynthesis of secondary metabolites
msak01120
Microbial metabolism in diverse environments
msak01240
Biosynthesis of cofactors
Module
msak_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
msak_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
msak00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MSAS_42390 (hemD)
Enzymes [BR:
msak01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MSAS_42390 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MSAS_42390 (hemD)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBX65065
UniProt:
A0A1X2BJV3
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Position
4459260..4460945
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AA seq
561 aa
AA seq
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MTTRGRKPRPGRITYVGSGPGDPGLLTTRAATVLANAALVFTDPDVPEPVLAMIGRDLPP
VSGPAPANPAVTHGDGSADPEAASPAVITGGPDIRPALGEPAEVAKTLTAEARAGADVVR
LVAGDPLTVDSVITEVNAVARTHLHLEIVPGLAATDAVPTYAGLPLGSSHTVADVRDPQV
DWDALAAAPGPLILQATASHLADAARTLIEHELAETTPCVVTAQGTTCQQRSIETTLQGL
ADPAVVSGVLHDPGAGLSAGDPQNGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTK
DQAGEMSERLTSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAV
WEKFGEFGLDARAFSGVKIACVGEQTADRVRAFGISPELVPAGEQSSLGLLDDFPPYDSI
FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAV
CFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAE
HAARLRAEGALPPPRKKSRRR
NT seq
1686 nt
NT seq
+upstream
nt +downstream
nt
atgacgacgcgagggcgtaagccgagaccgggccgcatcacctacgtgggttccggtcct
ggcgacccgggattgctgacgacgcgggccgccacggtactggccaatgccgccctggtc
ttcaccgaccccgacgtgcccgaaccggtgctcgcgatgatcggcagggacctgccgccg
gtgtccggcccggctccggccaacccggccgtgacgcacggcgacgggagtgccgacccc
gaagccgcctcgccggcggtgatcaccggcggccccgacatccgacccgcgctgggtgag
cccgccgaggtcgccaagacactgaccgcggaggcccgcgccggcgcggacgtggtgcgg
ctggtagccggcgacccactgacggtggactcggtgatcaccgaggtgaacgccgtcgcg
cgcacccacctgcacctcgagatcgtgccgggcctggcggccaccgacgccgtccccacc
tatgcggggctgccgctgggctcctcgcacacggtcgccgacgtgcgcgaccctcaggtg
gattgggacgctttggccgcggctcccggcccgctgatcctgcaggccacggcatcgcac
ctggccgacgcggcgcggaccctgatcgagcacgagctggccgagaccaccccatgcgtg
gtgaccgcccagggcaccacctgtcagcagcggtccatcgagaccaccctgcagggcctg
gccgacccggcggtggtcagcggcgtgctgcacgaccccggggcggggctgtccgccggg
gacccgcagaacggcccgctggtggtcaccatcggcaagaccgtagccaaccgggcgaag
ctgaactggtgggagagccgcgcgctctacggctggaccgtgctggtgccgcgtaccaag
gaccaggccggcgagatgagcgagcgtctgacctcctacggcgccctgcccatcgaggtg
cccaccattgccgtggagccgccgcgcagccccgcgcagatggagcgggcggtcaagggc
ctggtcgacggacgtttccagtgggtggtcttcacatccacgaacgcggtgcgcgcggtg
tgggagaagttcggcgaattcggcctggacgcccgcgcgttctccggcgtgaagatcgcc
tgcgtcggcgagcagacggccgaccgggtgcgcgccttcgggatcagccccgagctggtg
ccggccggggagcagtcctcgctgggcctgctcgacgacttcccgccctacgacagcatt
ttcgatccggtcaaccgcgtcctgctgccgcgcgccgacatcgccaccgagacgctggcc
gagggcctgcgcgagcgtggctgggagatcgaggacgtcaccgcgtaccggaccgtgcgc
gccgcgccgccgccggcggccacccgcgagatgatcaagaccggcggcttcgacgccgtg
tgcttcacgtccagctccaccgtgcggaacctggtcggcatcgcgggcaagccgcatgcg
cggacgatcatcgcctgcatcggccccaagaccgccgagaccgccgccgaattcgggttg
cgggtggacgtccagccggagaccgccgcggtcggtccgctggtcgacgccctggccgag
cacgccgcgcggttgcgggccgagggcgcgctgccgccgccgcgtaagaagagccgcagg
cgctag
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