Mycobacterium shottsii: MSHO_25970
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Entry
MSHO_25970 CDS
T07303
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
msho
Mycobacterium shottsii
Pathway
msho00860
Porphyrin metabolism
msho01100
Metabolic pathways
msho01110
Biosynthesis of secondary metabolites
msho01120
Microbial metabolism in diverse environments
msho01240
Biosynthesis of cofactors
Module
msho_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
msho_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
msho00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MSHO_25970 (hemD)
Enzymes [BR:
msho01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MSHO_25970 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MSHO_25970 (hemD)
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GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBX57252
UniProt:
A0A7I7LCK1
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Position
2481257..2482933
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AA seq
558 aa
AA seq
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MMTRGRKPRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGNDLPP
VSGPAPATAVADNADAASGGPAEGESDQAVSAVVSSGPDIRPALGDPTEVAKTLTAEARS
GADVVRLVAGDPMSVDAVIAEFNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVAD
VRGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVET
TLQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQA
GEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEK
FGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDP
VNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFT
SSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAA
RLRAEGALPPPRKKSRRR
NT seq
1677 nt
NT seq
+upstream
nt +downstream
nt
atgatgacgcgagggcgcaagccgaggccgggccgcattacttatgtgggctctggccca
ggtgacccgggtctgttgaccacacgggccgccgcggtactggcgaacgccgccctggtg
ttcacggaccccgatgtgcctgaatcggtgctggcactgatcggtaacgatctgccgccc
gtctccgggccggcgcccgcgactgcagtggccgacaatgctgacgctgcgtccggcggc
cccgcggagggtgagtccgaccaggcggtctcggcggtggtctctagtggtccggacatc
cgcccggcgctgggtgatcccaccgaagttgccaaaacgctgaccgccgaagcccgttcg
ggcgccgacgtggtgcgtttggtggccggtgacccgatgtcggtggacgcggtgatcgcc
gagttcaacgccattacccgcagccacctgcagatcgagatcctgcccggtctggcggca
accagcgcggtcccgacctatgcgggactgcccctgggctccgcgcacacggttgccgac
gtgcgtggcgacgtggactgggaggcgctggccgccgcaccgggtccgctgatcctgcag
gccaccgcgtcacatctggctgacgcggcccgcacgctggttgagcacgagctggcggac
acaacgccgtgcgtggtgaccgcgcacggaaccacctgccaacagcgctcggtggaaacc
accctgcaggggctgaccgatccggccatcctgggcggaactgaccctgccggcccgctg
accgggccgctggtggtgaccatcggcaagaccgtgagcaatcgcgccaagctgaactgg
tgggagagccgggcactgtacggctggaccgtgttggtaccccgaaccaaagaccaggcc
ggcgaaatgagcgagcggctgacgtcctacggtgccctgccggtcgaggtgccgacgatc
gccgtcgaaccgccgcgcagcccggcgcagatggaacgcgcggttaaaggcctcgtcgac
ggccggttccaatgggtcgtgttcacctccaccaacgccgtgcgcgcggtgtgggagaag
ttcggcgagttcggcctggacgcccgggcgttctccggagtgaagatcgcctgtgtgggc
gagtcgactgccgatcgggttcgcgctttcgggatcagcccggagctggtcccggccggg
gaacagtcctcgctgggcctgctggacgaattcccgccctacgacagcattttcgatccg
gtcaaccgggtgttgctgccgcgcgctgacatcgccaccgagacgctggccgaggggctg
cgcgagcgtggctgggagatcgaggacgtgacggcctaccgcacggtgcgggccgctccg
ccgccggcggccacccgcgagatgatcaagacgggcggtttcgacgcggtctgcttcacc
tcgagttctacggtgcgcaatctggtcggtatcgccggtaagccgcacgcgcggaccatc
atcgcctgcatcggacccaagaccgccgaaacggccgccgagttcgggctccgggtggat
gtccaacccgagaccgccgcggtgggcccgctggtggacgcgctggccgagcacgccgcc
cggctgcgcgccgaaggagccctgcccccgcctcgcaagaagagtcgccggcgctag
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