Mycobacterium simiae: MSIM_17390
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Entry
MSIM_17390 CDS
T07396
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
msim
Mycobacterium simiae
Pathway
msim00860
Porphyrin metabolism
msim01100
Metabolic pathways
msim01110
Biosynthesis of secondary metabolites
msim01120
Microbial metabolism in diverse environments
msim01240
Biosynthesis of cofactors
Module
msim_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
msim_M00925
Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
msim_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
msim00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MSIM_17390 (hemD)
Enzymes [BR:
msim01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MSIM_17390 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MSIM_17390 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBX40288
UniProt:
A0A7I7KG08
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Position
complement(1860483..1862153)
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AA seq
556 aa
AA seq
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MTTRGRKPRPGRITFVGSGPGDPGLLTTRAATVLANAALVFTDPDVPEPVLALIGTDLPP
VSGPAPADPPVGPTEGSTDGDAPSTAPAVLSGGADVRPALGEPAEVAKTLTAEARAGVDV
VRLVAGDPLTLDAVISEVNAVARTHLHVEIVPGLAPTSAVPTYAGLPLGSSHTVADVRDP
NVDWEALAAAPGPLILQATPTHLAEAARTLIEHELSEATPCVVTAQGTTCQQRSVETTLQ
GLTDPAVVAGAGDPAGPLTGPLVVTIGKTVNSRSKLNWWESRALYGWTVLVPRTKDQAGE
MSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFG
EFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPYDSIFDPVN
RVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFTSS
STVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAIGPLVDALAEHAARL
RAEGALPPPRKKSRRR
NT seq
1671 nt
NT seq
+upstream
nt +downstream
nt
atgacgacgcgagggcgcaagccgagaccgggccgcatcacgttcgtgggttccggcccg
ggtgacccgggattgttgaccacgcgggcggccaccgtgctggccaacgcggccttggta
ttcaccgatcccgacgtgcccgagccggtgctggcgctgatcggtacggacttgccgccc
gtgtcgggcccggcgcctgccgacccgccggtggggcccaccgagggctcaaccgatggc
gacgcaccgtcgaccgcacccgcggtgctgtccggcggtgccgacgtccgtccggcgctg
ggtgagcccgccgaggtggccaagacgctgacggccgaggcccgtgcgggggtcgacgtg
gtgcgcctggtggccggtgatccgctgacgctcgacgcggtgatcagcgaggtgaacgcc
gtcgcgcggacccacctgcatgtcgagatcgtcccggggctggcgccgaccagcgcggtg
ccgacctacgcgggtctgccgctgggttcctcgcacacggtggccgatgtgcgcgacccg
aatgtggattgggaggcactggcggcggctcccggaccgttgatcctgcaggccaccccg
acgcatctggccgaggcggcccgcaccctgatcgagcacgaattgtccgaggcgacgccg
tgcgtggtgaccgcgcagggcaccacctgtcagcagcggtcggtcgaaacgacgttgcag
gggctgaccgatccggccgtcgtggccggtgccggcgacccggccggcccgttgaccggg
ccgctggtggtgaccatcggcaagacggtgaacagccggtcgaagctgaactggtgggag
agtcgagccctgtacggctggaccgtgctggtgccgcgcaccaaggaccaggccggcgag
atgagcgagcggctgacgtcctacggcgcgctgccggtggaagtgccgaccatcgccgtc
gaacccccacgcagccccgcccagatggagcgtgccgtcaagggactggtcgacggccgg
ttccagtgggtcgtgttcacctcgaccaacgcggtgcgtgcggtgtgggagaagttcggc
gagttcggtctggacgcccgcgcattctccggtgtgaagatcgcctgtgtcggtgagtcg
acggctgaccgggtccgggcgttcgggatcagccccgagctggtgccggccggcgagcag
tcctcgctgggactgctcgacgacttcccgccctacgacagcattttcgacccggtcaac
cgggtgctgctgccgcgcgccgacatcgccaccgagacgctggccgaggggctgcgtgag
cgcggctgggagatcgaggatgtcaccgcctaccggacggtgcgcgcggcaccgccgcca
gcagccacccgtgaaatgatcaagacgggcggcttcgacgcggtgtgcttcacctctagc
tcgacggtgcgcaacctggtcggcattgccggtaaacctcacgcgcgcaccatcattgct
tgcatcggccccaagaccgcggagaccgcggctgaattcgggctacgggtggatgtgcag
cccgagacggcggccattggcccgctggtcgacgccctggccgagcacgctgcgcggttg
cgcgccgagggagcgctgccaccgccacgtaagaagagccgcaggcgctaa
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