Mycobacterium ulcerans: MUL_4600
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Entry
MUL_4600 CDS
T00435
Symbol
hemD
Name
(GenBank) uroporphyrin-III C-methyltransferase HemD
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mul
Mycobacterium ulcerans
Pathway
mul00860
Porphyrin metabolism
mul01100
Metabolic pathways
mul01110
Biosynthesis of secondary metabolites
mul01120
Microbial metabolism in diverse environments
mul01240
Biosynthesis of cofactors
Module
mul_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mul_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mul00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MUL_4600 (hemD)
Enzymes [BR:
mul01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MUL_4600 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MUL_4600 (hemD)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
ABL06549
Pasteur:
MUL_4600
UniProt:
A0PW30
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Position
5100701..5102374
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AA seq
557 aa
AA seq
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MTRGRKPRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGNDLPPV
SGPAPATAVADNADAATGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG
ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV
RGDVDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSVETT
LQGLTDPAILGGTDPAGPLTGPLVVTIGKTVSNRAKLNWWESRALYGWTVLVPRTKDQAG
EMSERLTSYGALPVEVPTIAVAPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF
GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPV
NRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFTS
SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAAR
LRAEGALPPPRKKSRRR
NT seq
1674 nt
NT seq
+upstream
nt +downstream
nt
atgacgcgagggcgcaagccgaggccgggccgcattacttatgtgggctctggcccaggt
gacccgggtctgttgaccacacgggccgccgcggtactggcgaacgccgccctggtgttc
acggaccccgatgtgcctgagtcggtgctggccctgatcggtaacgatctgccgcccgtc
tccgggccggcgcccgcgactgcagtggccgacaatgctgacgctgcgaccggcggcccc
gccgagggcgagtccgaccaggcggttccggcggtggtctctagtggtccggacatccgc
ccggcgctgggtgatcccaccgaagttgccaaaacgctgaccgccgaagcccgttcgggc
gccgacgtggtgcgtttggtggccggtgacccgatgtcggtggacgcggtgatcgccgag
gtcaacgccattacccgcagccacctgcagatcgagatcctgcccggtctggcggcaacc
agcgcggtcccgacctatgcgggactgcccctgggctccgcgcacacggttgccgacgtg
cgtggcgacgtggactgggaggcgctggccgccgcaccgggtccgctgatcctgcaggcc
accgcgtcacatctggctgacgcggcccgcacgctggttgagcacgagctggcggacaca
acgccgtgcgtggtgaccgcgcacggaaccacctgccaacagcgctcggtggaaaccacc
ctgcaggggctgaccgatccggccatcctgggtggaaccgaccctgccggcccgctgacc
gggccgctggtggtgaccatcggcaagaccgtgagcaatcgcgccaagctgaactggtgg
gagagccgggcactgtacggctggaccgtattggtaccccgaaccaaagaccaggccggc
gaaatgagcgagcggctgacgtcctacggtgccctgccggtcgaggtgccgacgatcgcc
gtcgcaccgccgcgcagcccggcgcagatggaacgcgcggtcaaaggcctggtcgacggc
cggttccaatgggtcgtgttcacctccaccaacgccgtgcgcgcggtgtgggagaagttc
ggcgagttcggcctggatgcccgggcgttctccggagtgaagatcgcctgtgtgggcgag
tcgactgccgaccgggttcgcgctttcgggatcagcccggagctggtcccggccggggaa
cagtcctcgctgggcctgctggacgaattcccgccctacgacagcattttcgatccggtc
aaccgggtgttgctgccgcgcgctgacatcgccaccgagacgctggccgaggggctgcgc
gagcgtggctgggagatcgaggacgtgacggcctaccgcacggtgcgggccgctccgccg
ccggcggccacccgcgagatgatcaagacgggcggtttcgacgcggtctgcttcacctcg
agttctacggtgcgcaatctggtcggtatcgccggtaagccgcacgcgcggaccatcatc
gcctgcatcggacccaagaccgccgaaacggccgccgagttcgggctccgggtggatgtc
caacccgagactgccgcggtgggtccgctggtggacgcgctggccgagcacgccgcccgg
ctgcgcgccgaaggagccctgcccccgcctcgcaagaagagtcgccggcgctag
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