Nocardia cyriacigeorgica: NOCYR_4974
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Entry
NOCYR_4974 CDS
T01756
Name
(GenBank) putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase Porphyrin biosynthesis protein hemD [Includes: Uroporphyrinogen-III C-methyltransferase (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM); Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing]) ]
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
ncy
Nocardia cyriacigeorgica
Pathway
ncy00860
Porphyrin metabolism
ncy01100
Metabolic pathways
ncy01110
Biosynthesis of secondary metabolites
ncy01120
Microbial metabolism in diverse environments
ncy01240
Biosynthesis of cofactors
Module
ncy_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
ncy_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
ncy00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
NOCYR_4974
Enzymes [BR:
ncy01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
NOCYR_4974
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
NOCYR_4974
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
CCF65725
UniProt:
H6R3C7
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All DBs
Position
complement(5561110..5562672)
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AA seq
520 aa
AA seq
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MSRAAKKHPGRILFVGSGPGDPALLTVRAREVLGRATLAFTDPDVDKGVLALIGTAVEPG
PDGEPAVDVRPALGEPAEVAKTLIAEARAGHDVVRVVAGDPLTTDAVIAEVTTVTRSHMV
FEVLPGLPGGSAVPSYAGIALGSGHTEADVRGEVDWAALAAAPGPLVLHATSGHLAETAS
ALVEHGMAPQTPVAVTVRGTTRQQRTIEATLATLNSAASELVGPLVVTIGKVVAQRSKMS
WWESRALYGWTVLVPRTKDQAAEMSERLVTHGAIPMEVPTIAVEPPRSPAQMERAVKGLV
DGRYQWVVFTSTNAVRAVWEKFSEFGLDARAFSGVKIACVGEATADKVRSFGINPELLPS
GEQSSEGLLADFPPYDDVFDPVNRVLLPRADIATETLAEGLRDRGWEIDDVTAYRTVRAS
PPPAETREMIKTGGFDAVLFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRV
DVQPETAQVGPLVEALAEHAARLRAEGLLPPPRKKSRRSR
NT seq
1563 nt
NT seq
+upstream
nt +downstream
nt
atgagtcgagccgctaagaagcatcccggtcggatcctgttcgtcgggtcgggtccagga
gatccggcgctgctcaccgtgcgggcccgcgaggtgctcggccgggcaacgctcgccttc
accgaccccgatgtcgacaagggtgtgctcgccctgatcggcacggccgtcgagccggga
cccgacggcgagcccgccgtcgacgtgcggcccgctctcggtgagccggccgaggtcgcc
aagacgctgatcgccgaggcccgcgccggacacgatgtggtgcgcgtggtcgccggcgat
ccgctgaccaccgacgcggtgatcgccgaggtcaccaccgtgactcgctcgcacatggtg
ttcgaggtgctgccgggtctgcccggtgggtcggcggtgccgagctacgccggtatcgca
ctgggatcgggccacaccgaggccgatgtgcgcggcgaggtggactgggcggcactggcc
gccgcgcccgggccgctggtgctgcacgccacctccggacacctggccgagaccgccagc
gcgctggtcgagcacggtatggccccgcagacgccggtcgcggtgaccgtgcgcggcacc
acccggcagcagcgcaccatcgaagccaccctggccacgctcaacagcgccgcctccgaa
ctggtgggcccactggtggtgaccatcggcaaggtggtcgcgcagcggtcgaagatgtcg
tggtgggaatcgcgggcactgtacggctggaccgtgctggtgccgcgcaccaaggatcag
gccgccgagatgagcgagcgcctggtcacccacggcgccatcccgatggaagtgccgacc
atcgcggtcgagccgccgcgcagccccgcgcagatggagcgcgcggtcaagggcctggtc
gacggccgctaccagtgggtggtgttcacctccaccaacgcggtgcgcgcggtgtgggag
aagttctccgagttcggactggacgcgcgggcgttctccggggtgaagatcgcctgcgtc
ggcgaggccaccgcggacaaggtgcgctcgttcggcatcaacccggaactgctgcccagc
ggtgaacagtcctccgagggcctgctcgccgacttcccgccctacgacgacgtgttcgat
ccggtgaaccgggtgctgctgccgcgcgccgatatcgccaccgagacgctggccgagggg
ctgcgcgaccgcggctgggaaatcgacgacgtcaccgcctaccgcacggtgcgtgcctcg
ccgccgccggccgagacccgcgagatgatcaagaccggtggtttcgacgcggtcctgttc
acctcgtcctccaccgtccgcaacctggtcggtatcgccggtaagccgcacgcccgcacc
atcgtcgcgtgcatcggccccaagaccgccgagaccgccatcgagttcggcctgcgcgtg
gacgtgcagccggaaaccgcccaggtcggcccgctggtggaggccctggccgagcatgcc
gcccggctgcgcgccgagggcctgctgcccccgccgcgcaagaagagccgccgcagccgc
tag
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