Nomascus leucogenys (northern white-cheeked gibbon): 100579506
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Entry
100579506 CDS
T03265
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
nle
Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01521
EGFR tyrosine kinase inhibitor resistance
nle01522
Endocrine resistance
nle04010
MAPK signaling pathway
nle04012
ErbB signaling pathway
nle04014
Ras signaling pathway
nle04015
Rap1 signaling pathway
nle04022
cGMP-PKG signaling pathway
nle04024
cAMP signaling pathway
nle04062
Chemokine signaling pathway
nle04066
HIF-1 signaling pathway
nle04068
FoxO signaling pathway
nle04071
Sphingolipid signaling pathway
nle04072
Phospholipase D signaling pathway
nle04114
Oocyte meiosis
nle04140
Autophagy - animal
nle04148
Efferocytosis
nle04150
mTOR signaling pathway
nle04151
PI3K-Akt signaling pathway
nle04210
Apoptosis
nle04218
Cellular senescence
nle04270
Vascular smooth muscle contraction
nle04370
VEGF signaling pathway
nle04371
Apelin signaling pathway
nle04380
Osteoclast differentiation
nle04510
Focal adhesion
nle04540
Gap junction
nle04550
Signaling pathways regulating pluripotency of stem cells
nle04613
Neutrophil extracellular trap formation
nle04620
Toll-like receptor signaling pathway
nle04650
Natural killer cell mediated cytotoxicity
nle04660
T cell receptor signaling pathway
nle04662
B cell receptor signaling pathway
nle04664
Fc epsilon RI signaling pathway
nle04666
Fc gamma R-mediated phagocytosis
nle04668
TNF signaling pathway
nle04720
Long-term potentiation
nle04722
Neurotrophin signaling pathway
nle04725
Cholinergic synapse
nle04726
Serotonergic synapse
nle04730
Long-term depression
nle04810
Regulation of actin cytoskeleton
nle04910
Insulin signaling pathway
nle04912
GnRH signaling pathway
nle04914
Progesterone-mediated oocyte maturation
nle04915
Estrogen signaling pathway
nle04916
Melanogenesis
nle04917
Prolactin signaling pathway
nle04919
Thyroid hormone signaling pathway
nle04921
Oxytocin signaling pathway
nle04926
Relaxin signaling pathway
nle04928
Parathyroid hormone synthesis, secretion and action
nle04929
GnRH secretion
nle04934
Cushing syndrome
nle04935
Growth hormone synthesis, secretion and action
nle05010
Alzheimer disease
nle05022
Pathways of neurodegeneration - multiple diseases
nle05034
Alcoholism
nle05132
Salmonella infection
nle05135
Yersinia infection
nle05160
Hepatitis C
nle05161
Hepatitis B
nle05163
Human cytomegalovirus infection
nle05164
Influenza A
nle05165
Human papillomavirus infection
nle05166
Human T-cell leukemia virus 1 infection
nle05167
Kaposi sarcoma-associated herpesvirus infection
nle05170
Human immunodeficiency virus 1 infection
nle05200
Pathways in cancer
nle05205
Proteoglycans in cancer
nle05206
MicroRNAs in cancer
nle05207
Chemical carcinogenesis - receptor activation
nle05208
Chemical carcinogenesis - reactive oxygen species
nle05210
Colorectal cancer
nle05211
Renal cell carcinoma
nle05212
Pancreatic cancer
nle05213
Endometrial cancer
nle05214
Glioma
nle05215
Prostate cancer
nle05216
Thyroid cancer
nle05218
Melanoma
nle05219
Bladder cancer
nle05220
Chronic myeloid leukemia
nle05221
Acute myeloid leukemia
nle05223
Non-small cell lung cancer
nle05224
Breast cancer
nle05225
Hepatocellular carcinoma
nle05226
Gastric cancer
nle05230
Central carbon metabolism in cancer
nle05231
Choline metabolism in cancer
nle05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
nle00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100579506 (MAP2K1)
04012 ErbB signaling pathway
100579506 (MAP2K1)
04014 Ras signaling pathway
100579506 (MAP2K1)
04015 Rap1 signaling pathway
100579506 (MAP2K1)
04370 VEGF signaling pathway
100579506 (MAP2K1)
04371 Apelin signaling pathway
100579506 (MAP2K1)
04668 TNF signaling pathway
100579506 (MAP2K1)
04066 HIF-1 signaling pathway
100579506 (MAP2K1)
04068 FoxO signaling pathway
100579506 (MAP2K1)
04072 Phospholipase D signaling pathway
100579506 (MAP2K1)
04071 Sphingolipid signaling pathway
100579506 (MAP2K1)
04024 cAMP signaling pathway
100579506 (MAP2K1)
04022 cGMP-PKG signaling pathway
100579506 (MAP2K1)
04151 PI3K-Akt signaling pathway
100579506 (MAP2K1)
04150 mTOR signaling pathway
100579506 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100579506 (MAP2K1)
04148 Efferocytosis
100579506 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
100579506 (MAP2K1)
04210 Apoptosis
100579506 (MAP2K1)
04218 Cellular senescence
100579506 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100579506 (MAP2K1)
04540 Gap junction
100579506 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
100579506 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100579506 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100579506 (MAP2K1)
04620 Toll-like receptor signaling pathway
100579506 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
100579506 (MAP2K1)
04660 T cell receptor signaling pathway
100579506 (MAP2K1)
04662 B cell receptor signaling pathway
100579506 (MAP2K1)
04664 Fc epsilon RI signaling pathway
100579506 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
100579506 (MAP2K1)
04062 Chemokine signaling pathway
100579506 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
100579506 (MAP2K1)
04929 GnRH secretion
100579506 (MAP2K1)
04912 GnRH signaling pathway
100579506 (MAP2K1)
04915 Estrogen signaling pathway
100579506 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
100579506 (MAP2K1)
04917 Prolactin signaling pathway
100579506 (MAP2K1)
04921 Oxytocin signaling pathway
100579506 (MAP2K1)
04926 Relaxin signaling pathway
100579506 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
100579506 (MAP2K1)
04919 Thyroid hormone signaling pathway
100579506 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
100579506 (MAP2K1)
04916 Melanogenesis
100579506 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100579506 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
100579506 (MAP2K1)
04726 Serotonergic synapse
100579506 (MAP2K1)
04720 Long-term potentiation
100579506 (MAP2K1)
04730 Long-term depression
100579506 (MAP2K1)
04722 Neurotrophin signaling pathway
100579506 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
100579506 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100579506 (MAP2K1)
05206 MicroRNAs in cancer
100579506 (MAP2K1)
05205 Proteoglycans in cancer
100579506 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
100579506 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
100579506 (MAP2K1)
05230 Central carbon metabolism in cancer
100579506 (MAP2K1)
05231 Choline metabolism in cancer
100579506 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100579506 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
100579506 (MAP2K1)
05212 Pancreatic cancer
100579506 (MAP2K1)
05225 Hepatocellular carcinoma
100579506 (MAP2K1)
05226 Gastric cancer
100579506 (MAP2K1)
05214 Glioma
100579506 (MAP2K1)
05216 Thyroid cancer
100579506 (MAP2K1)
05221 Acute myeloid leukemia
100579506 (MAP2K1)
05220 Chronic myeloid leukemia
100579506 (MAP2K1)
05218 Melanoma
100579506 (MAP2K1)
05211 Renal cell carcinoma
100579506 (MAP2K1)
05219 Bladder cancer
100579506 (MAP2K1)
05215 Prostate cancer
100579506 (MAP2K1)
05213 Endometrial cancer
100579506 (MAP2K1)
05224 Breast cancer
100579506 (MAP2K1)
05223 Non-small cell lung cancer
100579506 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100579506 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
100579506 (MAP2K1)
05161 Hepatitis B
100579506 (MAP2K1)
05160 Hepatitis C
100579506 (MAP2K1)
05164 Influenza A
100579506 (MAP2K1)
05163 Human cytomegalovirus infection
100579506 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
100579506 (MAP2K1)
05165 Human papillomavirus infection
100579506 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
100579506 (MAP2K1)
05135 Yersinia infection
100579506 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100579506 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
100579506 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
100579506 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100579506 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100579506 (MAP2K1)
01522 Endocrine resistance
100579506 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
nle01001
]
100579506 (MAP2K1)
Enzymes [BR:
nle01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
100579506 (MAP2K1)
Protein kinases [BR:
nle01001
]
Serine/threonine kinases: STE group
STE7 family
100579506 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
100579506
NCBI-ProteinID:
XP_003267168
Ensembl:
ENSNLEG00000012913
UniProt:
A0A2I3GXI0
LinkDB
All DBs
Position
6:85681038..85782124
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcagtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gaacttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggc
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcatagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactctctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccacccaggccaaggacccccgggaggccccttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa
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