KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100579506
Entry
100579506         CDS       T03265                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01521  EGFR tyrosine kinase inhibitor resistance
nle01522  Endocrine resistance
nle04010  MAPK signaling pathway
nle04012  ErbB signaling pathway
nle04014  Ras signaling pathway
nle04015  Rap1 signaling pathway
nle04022  cGMP-PKG signaling pathway
nle04024  cAMP signaling pathway
nle04062  Chemokine signaling pathway
nle04066  HIF-1 signaling pathway
nle04068  FoxO signaling pathway
nle04071  Sphingolipid signaling pathway
nle04072  Phospholipase D signaling pathway
nle04114  Oocyte meiosis
nle04140  Autophagy - animal
nle04148  Efferocytosis
nle04150  mTOR signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04210  Apoptosis
nle04218  Cellular senescence
nle04270  Vascular smooth muscle contraction
nle04370  VEGF signaling pathway
nle04371  Apelin signaling pathway
nle04380  Osteoclast differentiation
nle04510  Focal adhesion
nle04540  Gap junction
nle04550  Signaling pathways regulating pluripotency of stem cells
nle04613  Neutrophil extracellular trap formation
nle04620  Toll-like receptor signaling pathway
nle04650  Natural killer cell mediated cytotoxicity
nle04660  T cell receptor signaling pathway
nle04662  B cell receptor signaling pathway
nle04664  Fc epsilon RI signaling pathway
nle04666  Fc gamma R-mediated phagocytosis
nle04668  TNF signaling pathway
nle04720  Long-term potentiation
nle04722  Neurotrophin signaling pathway
nle04725  Cholinergic synapse
nle04726  Serotonergic synapse
nle04730  Long-term depression
nle04810  Regulation of actin cytoskeleton
nle04910  Insulin signaling pathway
nle04912  GnRH signaling pathway
nle04914  Progesterone-mediated oocyte maturation
nle04915  Estrogen signaling pathway
nle04916  Melanogenesis
nle04917  Prolactin signaling pathway
nle04919  Thyroid hormone signaling pathway
nle04921  Oxytocin signaling pathway
nle04926  Relaxin signaling pathway
nle04928  Parathyroid hormone synthesis, secretion and action
nle04929  GnRH secretion
nle04934  Cushing syndrome
nle04935  Growth hormone synthesis, secretion and action
nle05010  Alzheimer disease
nle05022  Pathways of neurodegeneration - multiple diseases
nle05034  Alcoholism
nle05132  Salmonella infection
nle05135  Yersinia infection
nle05160  Hepatitis C
nle05161  Hepatitis B
nle05163  Human cytomegalovirus infection
nle05164  Influenza A
nle05165  Human papillomavirus infection
nle05166  Human T-cell leukemia virus 1 infection
nle05167  Kaposi sarcoma-associated herpesvirus infection
nle05170  Human immunodeficiency virus 1 infection
nle05200  Pathways in cancer
nle05205  Proteoglycans in cancer
nle05206  MicroRNAs in cancer
nle05207  Chemical carcinogenesis - receptor activation
nle05208  Chemical carcinogenesis - reactive oxygen species
nle05210  Colorectal cancer
nle05211  Renal cell carcinoma
nle05212  Pancreatic cancer
nle05213  Endometrial cancer
nle05214  Glioma
nle05215  Prostate cancer
nle05216  Thyroid cancer
nle05218  Melanoma
nle05219  Bladder cancer
nle05220  Chronic myeloid leukemia
nle05221  Acute myeloid leukemia
nle05223  Non-small cell lung cancer
nle05224  Breast cancer
nle05225  Hepatocellular carcinoma
nle05226  Gastric cancer
nle05230  Central carbon metabolism in cancer
nle05231  Choline metabolism in cancer
nle05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:nle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100579506 (MAP2K1)
   04012 ErbB signaling pathway
    100579506 (MAP2K1)
   04014 Ras signaling pathway
    100579506 (MAP2K1)
   04015 Rap1 signaling pathway
    100579506 (MAP2K1)
   04370 VEGF signaling pathway
    100579506 (MAP2K1)
   04371 Apelin signaling pathway
    100579506 (MAP2K1)
   04668 TNF signaling pathway
    100579506 (MAP2K1)
   04066 HIF-1 signaling pathway
    100579506 (MAP2K1)
   04068 FoxO signaling pathway
    100579506 (MAP2K1)
   04072 Phospholipase D signaling pathway
    100579506 (MAP2K1)
   04071 Sphingolipid signaling pathway
    100579506 (MAP2K1)
   04024 cAMP signaling pathway
    100579506 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    100579506 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    100579506 (MAP2K1)
   04150 mTOR signaling pathway
    100579506 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100579506 (MAP2K1)
   04148 Efferocytosis
    100579506 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    100579506 (MAP2K1)
   04210 Apoptosis
    100579506 (MAP2K1)
   04218 Cellular senescence
    100579506 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100579506 (MAP2K1)
   04540 Gap junction
    100579506 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100579506 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100579506 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100579506 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    100579506 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    100579506 (MAP2K1)
   04660 T cell receptor signaling pathway
    100579506 (MAP2K1)
   04662 B cell receptor signaling pathway
    100579506 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    100579506 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    100579506 (MAP2K1)
   04062 Chemokine signaling pathway
    100579506 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100579506 (MAP2K1)
   04929 GnRH secretion
    100579506 (MAP2K1)
   04912 GnRH signaling pathway
    100579506 (MAP2K1)
   04915 Estrogen signaling pathway
    100579506 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    100579506 (MAP2K1)
   04917 Prolactin signaling pathway
    100579506 (MAP2K1)
   04921 Oxytocin signaling pathway
    100579506 (MAP2K1)
   04926 Relaxin signaling pathway
    100579506 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    100579506 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    100579506 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    100579506 (MAP2K1)
   04916 Melanogenesis
    100579506 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100579506 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    100579506 (MAP2K1)
   04726 Serotonergic synapse
    100579506 (MAP2K1)
   04720 Long-term potentiation
    100579506 (MAP2K1)
   04730 Long-term depression
    100579506 (MAP2K1)
   04722 Neurotrophin signaling pathway
    100579506 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100579506 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100579506 (MAP2K1)
   05206 MicroRNAs in cancer
    100579506 (MAP2K1)
   05205 Proteoglycans in cancer
    100579506 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    100579506 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100579506 (MAP2K1)
   05230 Central carbon metabolism in cancer
    100579506 (MAP2K1)
   05231 Choline metabolism in cancer
    100579506 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100579506 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100579506 (MAP2K1)
   05212 Pancreatic cancer
    100579506 (MAP2K1)
   05225 Hepatocellular carcinoma
    100579506 (MAP2K1)
   05226 Gastric cancer
    100579506 (MAP2K1)
   05214 Glioma
    100579506 (MAP2K1)
   05216 Thyroid cancer
    100579506 (MAP2K1)
   05221 Acute myeloid leukemia
    100579506 (MAP2K1)
   05220 Chronic myeloid leukemia
    100579506 (MAP2K1)
   05218 Melanoma
    100579506 (MAP2K1)
   05211 Renal cell carcinoma
    100579506 (MAP2K1)
   05219 Bladder cancer
    100579506 (MAP2K1)
   05215 Prostate cancer
    100579506 (MAP2K1)
   05213 Endometrial cancer
    100579506 (MAP2K1)
   05224 Breast cancer
    100579506 (MAP2K1)
   05223 Non-small cell lung cancer
    100579506 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100579506 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    100579506 (MAP2K1)
   05161 Hepatitis B
    100579506 (MAP2K1)
   05160 Hepatitis C
    100579506 (MAP2K1)
   05164 Influenza A
    100579506 (MAP2K1)
   05163 Human cytomegalovirus infection
    100579506 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100579506 (MAP2K1)
   05165 Human papillomavirus infection
    100579506 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100579506 (MAP2K1)
   05135 Yersinia infection
    100579506 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100579506 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    100579506 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    100579506 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100579506 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100579506 (MAP2K1)
   01522 Endocrine resistance
    100579506 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nle01001]
    100579506 (MAP2K1)
Enzymes [BR:nle01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100579506 (MAP2K1)
Protein kinases [BR:nle01001]
 Serine/threonine kinases: STE group
  STE7 family
   100579506 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 100579506
NCBI-ProteinID: XP_003267168
Ensembl: ENSNLEG00000012913
UniProt: A0A2I3GXI0
LinkDB
Position
6:85681038..85782124
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcagtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gaacttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggc
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcatagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactctctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccacccaggccaaggacccccgggaggccccttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

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