Nomascus leucogenys (northern white-cheeked gibbon): 100591827
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Entry
100591827 CDS
T03265
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
nle
Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01521
EGFR tyrosine kinase inhibitor resistance
nle01522
Endocrine resistance
nle04010
MAPK signaling pathway
nle04012
ErbB signaling pathway
nle04014
Ras signaling pathway
nle04015
Rap1 signaling pathway
nle04022
cGMP-PKG signaling pathway
nle04024
cAMP signaling pathway
nle04066
HIF-1 signaling pathway
nle04068
FoxO signaling pathway
nle04071
Sphingolipid signaling pathway
nle04072
Phospholipase D signaling pathway
nle04140
Autophagy - animal
nle04148
Efferocytosis
nle04150
mTOR signaling pathway
nle04151
PI3K-Akt signaling pathway
nle04210
Apoptosis
nle04218
Cellular senescence
nle04270
Vascular smooth muscle contraction
nle04370
VEGF signaling pathway
nle04371
Apelin signaling pathway
nle04540
Gap junction
nle04550
Signaling pathways regulating pluripotency of stem cells
nle04613
Neutrophil extracellular trap formation
nle04620
Toll-like receptor signaling pathway
nle04650
Natural killer cell mediated cytotoxicity
nle04660
T cell receptor signaling pathway
nle04662
B cell receptor signaling pathway
nle04664
Fc epsilon RI signaling pathway
nle04720
Long-term potentiation
nle04722
Neurotrophin signaling pathway
nle04730
Long-term depression
nle04810
Regulation of actin cytoskeleton
nle04910
Insulin signaling pathway
nle04912
GnRH signaling pathway
nle04915
Estrogen signaling pathway
nle04916
Melanogenesis
nle04917
Prolactin signaling pathway
nle04919
Thyroid hormone signaling pathway
nle04921
Oxytocin signaling pathway
nle04926
Relaxin signaling pathway
nle04929
GnRH secretion
nle04934
Cushing syndrome
nle04935
Growth hormone synthesis, secretion and action
nle05010
Alzheimer disease
nle05022
Pathways of neurodegeneration - multiple diseases
nle05132
Salmonella infection
nle05135
Yersinia infection
nle05160
Hepatitis C
nle05161
Hepatitis B
nle05163
Human cytomegalovirus infection
nle05164
Influenza A
nle05165
Human papillomavirus infection
nle05166
Human T-cell leukemia virus 1 infection
nle05167
Kaposi sarcoma-associated herpesvirus infection
nle05170
Human immunodeficiency virus 1 infection
nle05200
Pathways in cancer
nle05205
Proteoglycans in cancer
nle05206
MicroRNAs in cancer
nle05207
Chemical carcinogenesis - receptor activation
nle05208
Chemical carcinogenesis - reactive oxygen species
nle05210
Colorectal cancer
nle05211
Renal cell carcinoma
nle05213
Endometrial cancer
nle05214
Glioma
nle05215
Prostate cancer
nle05216
Thyroid cancer
nle05218
Melanoma
nle05219
Bladder cancer
nle05220
Chronic myeloid leukemia
nle05221
Acute myeloid leukemia
nle05223
Non-small cell lung cancer
nle05224
Breast cancer
nle05225
Hepatocellular carcinoma
nle05226
Gastric cancer
nle05230
Central carbon metabolism in cancer
nle05231
Choline metabolism in cancer
nle05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
nle00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100591827 (MAP2K2)
04012 ErbB signaling pathway
100591827 (MAP2K2)
04014 Ras signaling pathway
100591827 (MAP2K2)
04015 Rap1 signaling pathway
100591827 (MAP2K2)
04370 VEGF signaling pathway
100591827 (MAP2K2)
04371 Apelin signaling pathway
100591827 (MAP2K2)
04066 HIF-1 signaling pathway
100591827 (MAP2K2)
04068 FoxO signaling pathway
100591827 (MAP2K2)
04072 Phospholipase D signaling pathway
100591827 (MAP2K2)
04071 Sphingolipid signaling pathway
100591827 (MAP2K2)
04024 cAMP signaling pathway
100591827 (MAP2K2)
04022 cGMP-PKG signaling pathway
100591827 (MAP2K2)
04151 PI3K-Akt signaling pathway
100591827 (MAP2K2)
04150 mTOR signaling pathway
100591827 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100591827 (MAP2K2)
04148 Efferocytosis
100591827 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
100591827 (MAP2K2)
04218 Cellular senescence
100591827 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
100591827 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
100591827 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100591827 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100591827 (MAP2K2)
04620 Toll-like receptor signaling pathway
100591827 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
100591827 (MAP2K2)
04660 T cell receptor signaling pathway
100591827 (MAP2K2)
04662 B cell receptor signaling pathway
100591827 (MAP2K2)
04664 Fc epsilon RI signaling pathway
100591827 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
100591827 (MAP2K2)
04929 GnRH secretion
100591827 (MAP2K2)
04912 GnRH signaling pathway
100591827 (MAP2K2)
04915 Estrogen signaling pathway
100591827 (MAP2K2)
04917 Prolactin signaling pathway
100591827 (MAP2K2)
04921 Oxytocin signaling pathway
100591827 (MAP2K2)
04926 Relaxin signaling pathway
100591827 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
100591827 (MAP2K2)
04919 Thyroid hormone signaling pathway
100591827 (MAP2K2)
04916 Melanogenesis
100591827 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100591827 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
100591827 (MAP2K2)
04730 Long-term depression
100591827 (MAP2K2)
04722 Neurotrophin signaling pathway
100591827 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100591827 (MAP2K2)
05206 MicroRNAs in cancer
100591827 (MAP2K2)
05205 Proteoglycans in cancer
100591827 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
100591827 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
100591827 (MAP2K2)
05230 Central carbon metabolism in cancer
100591827 (MAP2K2)
05231 Choline metabolism in cancer
100591827 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100591827 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
100591827 (MAP2K2)
05225 Hepatocellular carcinoma
100591827 (MAP2K2)
05226 Gastric cancer
100591827 (MAP2K2)
05214 Glioma
100591827 (MAP2K2)
05216 Thyroid cancer
100591827 (MAP2K2)
05221 Acute myeloid leukemia
100591827 (MAP2K2)
05220 Chronic myeloid leukemia
100591827 (MAP2K2)
05218 Melanoma
100591827 (MAP2K2)
05211 Renal cell carcinoma
100591827 (MAP2K2)
05219 Bladder cancer
100591827 (MAP2K2)
05215 Prostate cancer
100591827 (MAP2K2)
05213 Endometrial cancer
100591827 (MAP2K2)
05224 Breast cancer
100591827 (MAP2K2)
05223 Non-small cell lung cancer
100591827 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100591827 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
100591827 (MAP2K2)
05161 Hepatitis B
100591827 (MAP2K2)
05160 Hepatitis C
100591827 (MAP2K2)
05164 Influenza A
100591827 (MAP2K2)
05163 Human cytomegalovirus infection
100591827 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
100591827 (MAP2K2)
05165 Human papillomavirus infection
100591827 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
100591827 (MAP2K2)
05135 Yersinia infection
100591827 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
100591827 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
100591827 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100591827 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100591827 (MAP2K2)
01522 Endocrine resistance
100591827 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
nle01001
]
100591827 (MAP2K2)
Enzymes [BR:
nle01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
100591827 (MAP2K2)
Protein kinases [BR:
nle01001
]
Serine/threonine kinases: STE group
STE7 family
100591827 (MAP2K2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
CAMSAP_CC1
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
100591827
NCBI-ProteinID:
XP_004093182
Ensembl:
ENSNLEG00000003013
LinkDB
All DBs
Position
17:91696862..91728656
Genome browser
AA seq
400 aa
AA seq
DB search
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPISGHGVDSRPAMAIFELLDHIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccctaccatcgccgag
ggcccgtcccctaccagcgagggcgcctccgaggcaaacctggtggacctgcagaagaag
ctggaggagctggaacttgacgagcagcagaagaagcggctggaagcctttctcacccag
aaagccaaggtcggcgaactcaaagatgatgacttcgaaaggatctcagagctgggcgcg
ggcaacggcggggtggtcaccaaagtccagcacagaccctcaggcctcatcatggccagg
aagctgatccacctcgagatcaagccggccatccggaaccagatcatccgtgagctgcag
gtcctgcatgagtgcaactcgccgtacatcgtgggcttctacggggccttctacagcgac
ggggagatcagcatctgcatggagcacatggatggcggctccctggaccaggtgctgaaa
gaggccaagaggattccggaggagatcctggggaaagtcagcatcgcggttctccggggc
ttggcgtacctccgagagaagcaccagatcatgcaccgagatgtgaagccctccaacatc
ctcgtgaactctagaggggagatcaagctgtgtgacttcggggtgagcggccagctcatc
gactccatggccaactccttcgtgggcacgcgctcctacatggctccggagcggttgcag
ggcacacattactcggtgcagtcggacatctggagcatgggcctgtccctggtggagctg
gccatcggaaggtaccccatccccccgcccgatgccaaggagctggaggccatctttggc
cggcccgtggtcgacggggaagaaggagagcctcacagcatctcgcctcggccgaggccc
cccgggcgccccatcagcggtcacggggtggatagccggcccgccatggccatctttgaa
ctgctggaccatattgtgaacgagccgcctcctaagctgcccaatggtgtgttcaccccc
gacttccaggagtttgtcaataaatgcctcatcaagaacccagcggagcgggcggacctg
aagatgctcacaaaccacaccttcatcaagcggtcagaggtggaagaagtggattttgcc
ggctggttgtgtaaaaccctgcggctgaaccagcccggcacacccacgcgcaccgccgtg
tga
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