Nomascus leucogenys (northern white-cheeked gibbon): 100604145
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Entry
100604145 CDS
T03265
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
nle
Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle00562
Inositol phosphate metabolism
nle01100
Metabolic pathways
nle01521
EGFR tyrosine kinase inhibitor resistance
nle04012
ErbB signaling pathway
nle04014
Ras signaling pathway
nle04020
Calcium signaling pathway
nle04062
Chemokine signaling pathway
nle04064
NF-kappa B signaling pathway
nle04066
HIF-1 signaling pathway
nle04070
Phosphatidylinositol signaling system
nle04072
Phospholipase D signaling pathway
nle04360
Axon guidance
nle04370
VEGF signaling pathway
nle04380
Osteoclast differentiation
nle04611
Platelet activation
nle04613
Neutrophil extracellular trap formation
nle04625
C-type lectin receptor signaling pathway
nle04650
Natural killer cell mediated cytotoxicity
nle04662
B cell receptor signaling pathway
nle04664
Fc epsilon RI signaling pathway
nle04666
Fc gamma R-mediated phagocytosis
nle04670
Leukocyte transendothelial migration
nle04722
Neurotrophin signaling pathway
nle04750
Inflammatory mediator regulation of TRP channels
nle04919
Thyroid hormone signaling pathway
nle04933
AGE-RAGE signaling pathway in diabetic complications
nle04935
Growth hormone synthesis, secretion and action
nle05167
Kaposi sarcoma-associated herpesvirus infection
nle05169
Epstein-Barr virus infection
nle05170
Human immunodeficiency virus 1 infection
nle05171
Coronavirus disease - COVID-19
nle05200
Pathways in cancer
nle05205
Proteoglycans in cancer
nle05206
MicroRNAs in cancer
nle05214
Glioma
nle05223
Non-small cell lung cancer
nle05225
Hepatocellular carcinoma
Module
nle_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
nle00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
100604145 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
100604145 (PLCG2)
04014 Ras signaling pathway
100604145 (PLCG2)
04370 VEGF signaling pathway
100604145 (PLCG2)
04064 NF-kappa B signaling pathway
100604145 (PLCG2)
04066 HIF-1 signaling pathway
100604145 (PLCG2)
04020 Calcium signaling pathway
100604145 (PLCG2)
04070 Phosphatidylinositol signaling system
100604145 (PLCG2)
04072 Phospholipase D signaling pathway
100604145 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100604145 (PLCG2)
04613 Neutrophil extracellular trap formation
100604145 (PLCG2)
04625 C-type lectin receptor signaling pathway
100604145 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
100604145 (PLCG2)
04662 B cell receptor signaling pathway
100604145 (PLCG2)
04664 Fc epsilon RI signaling pathway
100604145 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
100604145 (PLCG2)
04670 Leukocyte transendothelial migration
100604145 (PLCG2)
04062 Chemokine signaling pathway
100604145 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
100604145 (PLCG2)
04919 Thyroid hormone signaling pathway
100604145 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
100604145 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
100604145 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
100604145 (PLCG2)
04380 Osteoclast differentiation
100604145 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100604145 (PLCG2)
05206 MicroRNAs in cancer
100604145 (PLCG2)
05205 Proteoglycans in cancer
100604145 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
100604145 (PLCG2)
05214 Glioma
100604145 (PLCG2)
05223 Non-small cell lung cancer
100604145 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100604145 (PLCG2)
05171 Coronavirus disease - COVID-19
100604145 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
100604145 (PLCG2)
05169 Epstein-Barr virus infection
100604145 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100604145 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100604145 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
nle04131
]
100604145 (PLCG2)
Enzymes [BR:
nle01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
100604145 (PLCG2)
Membrane trafficking [BR:
nle04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
100604145 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
100604145 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
C2
SH3_1
SH3_9
PH
PH_12
SH3_2
PH_14
EF-hand_like
GDPD
Motif
Other DBs
NCBI-GeneID:
100604145
NCBI-ProteinID:
XP_030675215
Ensembl:
ENSNLEG00000010678
LinkDB
All DBs
Position
2:147947978..148117878
Genome browser
AA seq
1265 aa
AA seq
DB search
MSTIVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
FKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEAPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgtccaccatagtcaatgtggattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgagcgagcaaaagccgttcgccagaaagaagactgctgcttcaccatcctgtat
ggcactcagtttgtcctcagcacgctcagcttggcagctgactctaaagaagatgcagtt
aattggctctctggcttgaaaatcttacaccaagaagcgatgaatgcgtccacacccact
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattcttgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctccgcc
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgatgataccatgcgtgaaact
gctgagcctttcttgtttgtggatgagttcctcacatacttgttttcacgagaaaacagc
atctgggatgagaagtatgatgcggtggacatgcaggatatgaacaaccccctgtctcat
tactggatctcctcgtctcataatacgtacctcacaggtgaccagctgcggagcgagtca
tccccggaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccggtcatctaccacggctggacgcggaccaccaagatc
aaatttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttccca
gtgatcctgtccattgaggagcactgcagcgtggaacagcagcgtcacatggccaaggcc
ttcaaggaagtgtttggcgacctgctgctgatgaagcccacggaggccagcgctgaccag
ctgccctcacccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggtgacgtggatgtcaacgtggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccatcgccgat
gccaagctgtccttcagtgatgacattgaacagactatggaggaggaagcgccccaggat
ataccccccacagagctacattttggggagaaatggttccacaagaaggtagagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactac
ctgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
catgagtccaagccgtggtactatgacagcctgagccgtggagaggcagaggacatgctg
atgaggattccccgggacggagccttcctgatccggaagcgagagggaagcgactcctac
gccatcaccttcagggctaggggcaaggtgaagcactgtcgcatcaaccgggacggccgg
cactttgtgctggggacctccgcctattttgagagcctcgtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaatatggaaagagacataaactccctctacgatgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaacggtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatttcaactgcagatgtcgaggagctagaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtt
gtgaaagcccctcagggaaaaaaccagaagccctttgtctttatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctctttgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaattcgctcctttgtggag
acaaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaag
ggcctgactcgtgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacaccagataagtac
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgaggacagagaaatatgacccgatgccacctgagtcccagaggaagatcctg
atgacgctgacggtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaggtggagatctgtggagccgagtatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acgtttgaaatttatgacccaaacctggcatttctgcgcttcgtggtttacgaagaagac
atgttcagcgatcccaactttcttgcccatgccacttaccccattaaagcaatcaaatca
ggattcaggtccgttcctctgaagaatgggtacagcgaggacatagaactggcttccctc
ctggttttctgtgagatgcggccagtactggagagcgaagaggaactttactcctcctgt
cgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctgattaaagagttcaatgttaatgagaac
cagcttcagctgtaccaagagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttattcatag
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integrated database retrieval system
