KEGG T08474: 110589350

Neomonachus schauinslandi (Hawaiian monk seal): 110589350

Entry

110589350         CDS       T08474

Name

(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase

K00512

steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]

Organism

nsu Neomonachus schauinslandi (Hawaiian monk seal)

Pathway

nsu00140

Steroid hormone biosynthesis

nsu01100

Metabolic pathways

nsu04913

Ovarian steroidogenesis

nsu04917

Prolactin signaling pathway

nsu04927

Cortisol synthesis and secretion

nsu04934

Cushing syndrome

Module

nsu_M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

nsu_M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

nsu_M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

Brite

KEGG Orthology (KO) [BR:nsu00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    110589350
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    110589350
   04917 Prolactin signaling pathway
    110589350
   04927 Cortisol synthesis and secretion
    110589350
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110589350
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:nsu00199]
    110589350
Enzymes [BR:nsu01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     110589350
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     110589350
Cytochrome P450 [BR:nsu00199]
Cytochrome P450, animal type
  CYP17 family
   110589350

SSDB

Motif

Pfam:

p450 DUF2714

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

EnsemblRapid:

UniProt:

LinkDB

Position

6:complement(128562197..128568044)

AA seq 508 aa
MWELFAFLLFALAYFLWPKPKCPSAKYPKSLPSLPLVGSLPFLPRGGHPHVNFFKLQKKY
GPIYSFRMGTKTTVMVGHHQLAKEVLVKKGKEFSGRPQGVTLDILSDNQKGIAFADHGAN
WQLHRKLVLATFALFKDGDQRLEKIICQENSLLCDFLATQNGQSIDLSLPLFLAVTNIIC
LICFNSSYKNGDPALKIIKNYNDGILDSLGTDKMVDIFPRLKIFPNKTVEKMKNCVKMRD
ELLNEILEKHKENFSSDSITNLLDILIQARMNSDNNNAASDRDSKLLSDKHILTTIGDIF
GAGVETTTSVVKWTVAFLLHNPQLQKKIQEEIDQKVGFSRTPTMSDRNQLILLEATIREV
LRIRPVAPTLIPHKAIVDSSIGEFAIDKGTNVIINLWALHHNEKEWHRPDQFVPERFLDP
TRSQLISPSLSYLPFGAGPRSCLGEILARQELFLVMSWLLQRFDLEIPDDGQLPSLEGNP
KMVFLIEAFKVKIKVRQAWREAQAESST

NT seq 1527 nt +upstreamnt +downstreamnt
atgtgggagctcttcgcttttttgctgttcgcccttgcctatttcttatggcccaagcca
aaatgccccagtgccaagtatcccaagagcctcccatccctgccgttggtgggcagcctg
ccattcctccccagaggtggccatccgcacgtgaacttcttcaagctgcagaaaaaatac
ggccccatctattcctttcgcatgggtaccaagactacagtgatggtcggccaccaccag
ctggccaaggaggtgcttgtcaagaagggcaaggaattctctgggcggccccaaggggta
actctggacatcctgtctgacaaccaaaagggcatcgccttcgcagaccatggtgccaac
tggcagctgcataggaagctggtactggccacctttgccctgttcaaggatggcgaccag
aggctagagaagatcatttgtcaggaaaacagtttattgtgtgatttcctggccacccag
aatggacagtccatagacttgtccttgcctctcttcctggcggtgaccaacataatctgc
ttgatttgcttcaactcctcctacaagaatggagatcctgctctgaagatcataaagaat
tataatgacggcatcttggattctctgggaacggataaaatggtagacatattccccagg
ttgaagattttccccaacaaaaccgtggaaaaaatgaagaactgtgttaaaatgcgagat
gaattgctgaatgaaatccttgaaaaacataaggagaacttcagcagcgactctatcacc
aacctgctggacatactgatccaagccaggatgaactcagacaataacaatgctgcctca
gaccgggattcaaaactcctttcagataaacatattctcaccaccataggggatatcttt
ggggccggtgtagagaccaccacgtctgtggtgaagtggactgtggccttcctgctacac
aatcctcagttgcagaagaagatccaggaggagattgaccagaaggtgggtttcagccgc
acaccaactatgagtgaccggaatcaactcatcttgctagaggccaccatcagagaggtg
cttcgcatccggcctgtggcccctacactcatcccccacaaggctatcgttgattccagc
attggcgagtttgccattgacaagggcacaaatgttatcatcaatttgtgggcactgcat
cacaatgagaaggagtggcaccggccggaccagttcgtgccagagcgcttcttggacccc
acgaggagtcagctcatctctccgtcactaagttacttgcccttcggagcaggaccccgc
tcttgcctaggtgagatcctggcccgccaggagctcttcctcgtcatgtcctggttgctg
cagaggtttgacctggagatcccagatgatgggcagctgccttccctggaggggaacccc
aagatggtctttttgatcgaggctttcaaagtgaagatcaaggtgcgccaggcctggagg
gaggcccaggctgagagtagcacctag

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