Ornithorhynchus anatinus (platypus): 100079104 Help Entry 100079104         CDS       T01045                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism oaa  Ornithorhynchus anatinus (platypus) Pathway oaa04010   MAPK signaling pathway oaa04014   Ras signaling pathway oaa04015   Rap1 signaling pathway oaa04022   cGMP-PKG signaling pathway oaa04066   HIF-1 signaling pathway oaa04068   FoxO signaling pathway oaa04072   Phospholipase D signaling pathway oaa04150   mTOR signaling pathway oaa04151   PI3K-Akt signaling pathway oaa04152   AMPK signaling pathway oaa04211   Longevity regulating pathway oaa04213   Longevity regulating pathway - multiple species oaa04520   Adherens junction oaa04910   Insulin signaling pathway oaa04913   Ovarian steroidogenesis oaa04923   Regulation of lipolysis in adipocytes oaa04930   Type II diabetes mellitus oaa04931   Insulin resistance oaa04932   Non-alcoholic fatty liver disease oaa04960   Aldosterone-regulated sodium reabsorption oaa05010   Alzheimer disease oaa05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:oaa00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     100079104 (INSR)    04014 Ras signaling pathway     100079104 (INSR)    04015 Rap1 signaling pathway     100079104 (INSR)    04066 HIF-1 signaling pathway     100079104 (INSR)    04068 FoxO signaling pathway     100079104 (INSR)    04072 Phospholipase D signaling pathway     100079104 (INSR)    04022 cGMP-PKG signaling pathway     100079104 (INSR)    04151 PI3K-Akt signaling pathway     100079104 (INSR)    04152 AMPK signaling pathway     100079104 (INSR)    04150 mTOR signaling pathway     100079104 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     100079104 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     100079104 (INSR)    04923 Regulation of lipolysis in adipocytes     100079104 (INSR)    04913 Ovarian steroidogenesis     100079104 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     100079104 (INSR)   09149 Aging    04211 Longevity regulating pathway     100079104 (INSR)    04213 Longevity regulating pathway - multiple species     100079104 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100079104 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     100079104 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100079104 (INSR)    04932 Non-alcoholic fatty liver disease     100079104 (INSR)    04931 Insulin resistance     100079104 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:oaa01001]     100079104 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:oaa04090]     100079104 (INSR) Enzymes [BR:oaa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      100079104 (INSR) Protein kinases [BR:oaa01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    100079104 (INSR) CD molecules [BR:oaa04090]  Proteins   100079104 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like Toxin_29 B2 Motif Other DBs NCBI-GeneID:  100079104 NCBI-ProteinID:  XP_028906070 Ensembl:  ENSOANG00000002002 LinkDB All DBs Position X1:112605866..112782826 Genome browser AA seq 1384 aa AA seqDB search MGPKATALVMALALVLGGSGSPGRSQYEGPVCPNMDIRNNLTQLYALENCSVIEGHLQIL LMFKTKPEDFRGLSFPKLTMITDYLLLFRVYGLESLKDLFPNLTVIRGTRLFFNYALVIF EMVHLKEIGLYNLMNITRGAVRIEKNNELCYLSTIDWSRILDSVEDNYIVENKDDKEECG DVCPGTVKGKSNCPATVINGLFIERCWTHDHCQKVCPAPCKWQGCTSDGQCCHSECLGNC SEPNDPEKCIACRHFDLDGKCVETCPPNYYRFQEWRCVNFSFCQSLHNNCKNSRQSGCHQ YVIHNNKCVPECPSGYIMNSTNLNCSPCSGPCPKVCNMYGEKTIDSVTSAQELQGCTVIN GSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLQLIKGETLEAGN YSFYALDNQNLRQLWDWSKHNLTIAQGKLFFHYNPKLCLSEIHKMEEISGTKGRQERNDI ALKTNGDQASCENELLRFSQIRTSFDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQNVTE FDGQDACGSNSWTVVDVEPPQRSNDPKSQSSPGWLMRGLKPWTQYAVFVKTLVTFSDERR TYGAKSEIIYVQTNATVPSVPLDPISVSNSSSQIILKWKPPSEPNGNITHYLVFWEQQAE DSELYELDYCLKGLKLPSRTWSPPFESEDSQKQNRSDNEDHGGECCSCPKTDSQIQKEAE ESSFRKTFENYLHNEVFVPRKTSSGNGSVDSRPNRKRRDLGSRTNATVVTPTIPTLSNTS STPAPESREEQKPFEKVESKESLVISGLRHFTGYRIELHACNHDAQESRCSVAAYVSART MPEAKADDIVGPVTHEVSDNNIVHLKWQEPKEPNGLIVLYEVNYWRLGENEENMLPFSFL QELHHCVSRKHFANERGCKLRGLHPGNYTVRIRATSLAGNGSWTEPTYFYVADYLDVPSN IAKIIIGPVIFAIFVVGMIGAIYVFVKKRQTEGPTGPLYASSNPEYLSASDVYVPDEWEV PRDKISLLRELGQGSFGMVYEGNAKDIIKGELETHVAVKTVNESASLRERIEFLNEASVM KGFSCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPDAENNPGRPPPTLPEMIQ MAAEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLL PVRWMAPESLKDGVFTAYSDVWSFGVVLWEISSLAEQPYQGLSNEQVLKFVMDGGYLDQP DNCPERVNHLMQMCWQYNPKMRPTFIEIIEMLKEDLHPSFQSVSFFYSEENKPPETEEFE MDFENMESIPLDPSSYSQRDEVLGRDNGPSLALKGNYEEHIPYTHMNGGKKNGRILSLPR SSPS NT seq 4155 nt NT seq  +upstreamnt  +downstreamnt atgggaccgaaggcgacggcgctggtgatggccctggcgctagtgctgggcggttcgggc agcccgggacggagccagtacgaggggccggtttgcccgaacatggacattcgaaataac ttgacacagctgtatgctctagaaaactgctctgtgatcgagggccacttgcaaatactg ctcatgtttaaaaccaagcctgaagatttccgaggacttagttttcccaaacttactatg attacagactatttattacttttccgggtgtacggcctagagagtttaaaggacctcttc cccaatctcactgttatccgtggaacccgtctcttttttaactatgccctggtcatcttt gagatggttcacttgaaagaaattggcctttataatctaatgaatatcacccgaggagca gttcggattgagaagaataacgagctgtgctacttgtccactattgactggtctcgaatt ttagattccgttgaagataactacatcgttgaaaacaaagatgataaagaagaatgcgga gatgtttgtcctggaactgtgaaaggaaaaagcaactgcccagctactgtaataaatggt cttttcatcgaaaggtgttggacccatgaccactgtcagaaagtttgcccagccccctgt aagtggcagggttgcacctcagacggtcaatgctgtcacagcgagtgcctgggaaactgc tcagagccgaacgatcccgagaaatgcattgcgtgccggcacttcgacctcgatggcaag tgtgttgaaacttgcccgccgaattactatcgctttcaggagtggcgttgtgtgaatttc agcttctgccagagtctgcacaacaattgcaagaattccaggcaatctggatgtcaccag tatgtcattcacaacaacaagtgtgttcctgagtgtccctctggatacattatgaattcc accaacctgaattgctctccttgttcagggccctgtccaaaggtttgtaatatgtatggt gagaagaccattgattcggtaacatctgcacaggagcttcaagggtgtactgtcataaac ggaagcttgatcataaacatacgtggaggcaataatttagcggcagaactagaagccaac cttggcttaattgaagaaatttcgggttacctgaaaatccgtcgttcctatgccttagtg tctctgtctttcttccgtaaactgcaactgattaaaggggagacccttgaagctgggaat tattctttctatgccctggataatcagaacctgagacagctatgggactggagtaaacac aatctcaccattgcccaaggaaaattgttcttccattataaccccaaactctgcttatca gagattcacaaaatggaagaaatctccggaaccaaggggcgtcaagaaagaaatgacata gccttgaagacgaatggtgaccaagcatcctgtgaaaatgagctactcagattttcccaa atcagaacatctttcgacaagatcttactaaaatgggaaccttactggccacctgatttt cgagacctcttgggatttatgcttttctacaaagaagctccatatcaaaatgtgactgaa tttgatggtcaagatgcttgtggttcaaacagttggacggtggttgatgtagaacctccc cagcggtcaaatgatcccaaatcccagagctctccaggctggctaatgagggggttgaaa ccttggacccagtatgctgtctttgtcaaaaccttagtcaccttttctgatgagcgaaga acatacggagcaaagagtgaaatcatttatgtccagaccaatgctacagttccttccgtt cccttagatccaatatcagtttccaattcctcatcccagatcattttaaagtggaaacca ccttcagagccaaatggtaatatcacacactacttagtgttctgggagcaacaggctgag gatagcgaactctatgaacttgattattgcctgaagggattaaagttgccttcaaggacc tggtctcctcctttcgaatctgaagattctcagaaacagaatcgaagcgacaatgaggat catggtggagagtgttgttcttgcccaaaaactgattcccaaatacaaaaagaagctgaa gagtcttcatttaggaaaacatttgaaaattatctccataatgaggtttttgtgcccaga aaaacatcatcagggaatggatctgtggacagtaggccaaatcgcaaacgaagggatctt ggcagccggacaaatgccactgtggtgacacccacaattccaactttgtcaaacacctca tctacacctgcccctgaaagtagagaggaacagaaaccctttgagaaagttgaatctaag gaatccttggttatctctggtctgcggcattttactggctatcgcattgaactccacgcc tgcaatcatgatgcccaagaatccagatgcagcgtggctgcatatgtcagtgcaagaacc atgcctgaagcaaaggcagatgacattgttgggccagttactcatgaagtgtctgacaat aacattgtccacttgaagtggcaggagccaaaggagcccaatggattgattgttctctat gaagtgaactattggcgtcttggagaaaatgaggaaaacatgcttcctttctcctttttg caggaactgcatcattgtgtttcccggaaacattttgccaatgaacgtggatgtaaactc cgtggtctgcatcctggaaattatactgttcgaattcgagccacctcattggcaggaaat ggctcttggaccgaacccacctatttctatgttgcagattatttagatgttccgtctaat attgcaaaaattatcattggcccagtcatttttgccattttcgttgttggaatgattgga gctatttacgtgtttgtgaaaaagaggcaaacggaaggaccaaccgggccactttatgcc tcgtccaatccagaatacctcagtgctagtgacgtttatgtcccagatgagtgggaggta ccacgagacaaaatcagcctcctacgggaattgggccagggctcctttgggatggtgtat gaaggaaacgcgaaggatatcataaaaggagagctagagacgcacgtagcggtgaaaacc gttaatgaatctgcaagtctccgggagcgcattgagtttttaaatgaagcctctgtcatg aaaggttttagctgccatcatgtggtccgcctcttaggggtggtctccaaaggacagccc acattagtagtgatggagctgatggcccatggagatcttaaaagttacctccgttctttg cgtccagatgctgaaaataaccctggccgccccccgccaacactcccagagatgattcag atggccgccgagattgcagatggcatggcctacttgaatgcaaagaaatttgttcaccga gatttagcagcccgaaattgtatggttgcggaagactttactgtaaagattggagatttt ggaatgaccagagacatctacgaaactgattattaccgaaaaggagggaagggtctgctc cctgtaagatggatggcccctgagtccttaaaggatggagtctttacagcatattctgat gtgtggtcttttggcgtggtcctttgggagatcagcagcttggccgagcagccttaccag ggtctgtctaatgagcaggtgctgaaatttgtaatggatggaggatacctggatcaacct gataactgtcctgaaagagtaaaccacctgatgcagatgtgctggcagtataaccccaaa atgcgccccaccttcatcgagatcattgagatgctgaaggaggacctgcatcccagcttt cagagcgtgtcatttttttacagcgaagaaaacaagcctccagaaactgaggaattcgag atggactttgaaaacatggagagcattccgctcgacccatcttcatactcccagagggac gaagtcctggggcgggacaatgggccatctctggctctaaagggaaactacgaagaacac ataccttacacccacatgaatggtggcaagaaaaatggtcgcattctgtccctgcctagg tcgagcccttcctaa

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