Ovis aries (sheep): 443431 Help Entry 443431            CDS       T03117                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism oas  Ovis aries (sheep) Pathway oas04010   MAPK signaling pathway oas04014   Ras signaling pathway oas04015   Rap1 signaling pathway oas04022   cGMP-PKG signaling pathway oas04066   HIF-1 signaling pathway oas04068   FoxO signaling pathway oas04072   Phospholipase D signaling pathway oas04150   mTOR signaling pathway oas04151   PI3K-Akt signaling pathway oas04152   AMPK signaling pathway oas04211   Longevity regulating pathway oas04213   Longevity regulating pathway - multiple species oas04520   Adherens junction oas04910   Insulin signaling pathway oas04913   Ovarian steroidogenesis oas04923   Regulation of lipolysis in adipocytes oas04930   Type II diabetes mellitus oas04931   Insulin resistance oas04932   Non-alcoholic fatty liver disease oas04960   Aldosterone-regulated sodium reabsorption oas05010   Alzheimer disease oas05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:oas00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     443431 (INSR)    04014 Ras signaling pathway     443431 (INSR)    04015 Rap1 signaling pathway     443431 (INSR)    04066 HIF-1 signaling pathway     443431 (INSR)    04068 FoxO signaling pathway     443431 (INSR)    04072 Phospholipase D signaling pathway     443431 (INSR)    04022 cGMP-PKG signaling pathway     443431 (INSR)    04151 PI3K-Akt signaling pathway     443431 (INSR)    04152 AMPK signaling pathway     443431 (INSR)    04150 mTOR signaling pathway     443431 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     443431 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     443431 (INSR)    04923 Regulation of lipolysis in adipocytes     443431 (INSR)    04913 Ovarian steroidogenesis     443431 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     443431 (INSR)   09149 Aging    04211 Longevity regulating pathway     443431 (INSR)    04213 Longevity regulating pathway - multiple species     443431 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     443431 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     443431 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     443431 (INSR)    04932 Non-alcoholic fatty liver disease     443431 (INSR)    04931 Insulin resistance     443431 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:oas01001]     443431 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:oas04090]     443431 (INSR) Enzymes [BR:oas01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      443431 (INSR) Protein kinases [BR:oas01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    443431 (INSR) CD molecules [BR:oas04090]  Proteins   443431 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  443431 NCBI-ProteinID:  XP_004008598 EnsemblRapid:  ENSOARG00020007624 UniProt:  A0A6P3EDM5 W5NQ38 LinkDB All DBs Position 5:complement(13788125..13936266) Genome browser AA seq 1382 aa AA seqDB search MGAGGGSGAAAVLLLVVVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTSEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKTSRRQG CHQYVIHNNKCVPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TIINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWGKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPTRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFIPRKSSSGPVAEDARPSRKRRALGDVGNVTAAVPTVLGF PNSSSTSTPTSSEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGEEELHLCV SRRHYAVERGCRLRGLLPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIG PLIFVFLFSVVIGSICLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR EKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKG FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN CPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEME FEDMESVPLDRSSHAQREEAGVRDGGSALGLKRNYDEHIPYTHMNGGKKNGRILTLPRSN PS NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt atgggcgccgggggcgggagcggggcggcagccgtgctgctgctggtggtcgtcgccgcg ctgctggtgggcgccgcgggccacctgtaccctggagaagtgtgccccggtatggatatc cggaataatctcacccggctgcatgagctggccaactgctcggtcattgaaggacatttg cagattctgttgatgttcaaaacgagacctgaggacttccgagacctcagtttccccaaa ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacttgttccccaacctcacggtcatccgaggctcgcgcctcttctttaattatgcactg gtcatctttgagatggttcacctgaaggagcttggcctctacagcctgatgaacatcacc cgggggtctgtccgcatcgagaagaacaatgaactctgctacctggccaccatcgactgg tctcgcatcctggattccgtggaggataattacatcgtgctgaacaaagacgacaatgag gagtgtggggacatttgtccaggcaccgccaagggcaagaccaactgccctgccactgtc atcaacgggcagtttgtggagcggtgctggacacacagccactgccagaaagtgtgtccg actatctgtaagtcacatggctgcacctctgagggtctctgctgccacagcgagtgcttg ggcaactgctcagagcccgacgaccccaccaagtgcgtggcctgtcgcaacttctacctg gacggcaggtgcgtggagacctgcccgcccccttactaccacttccaagactggcgctgc gtgaacttcagcttctgccaggacctgcacaacaaatgcaagacctctcggaggcaaggc tgccaccagtatgtcattcacaacaacaagtgcgtccccgagtgcccctctggctacacg atgaattctagcaacttgatgtgtaccccttgcctgggcccctgtcccaaggtgtgccac ctcctggaaggtgagaagaccatcgattcagtgacatctgcccaggagcttcgaggctgc accatcatcaacggaagcttaatcatcaacattcgagggggcaacaacctggcagctgag ctagaggccaaccttggactcattgaagaaatttcaggatatctgaaaatccgccggtcc tatgccctggtgtcactttccttcttccggaagttacgtctgattcgaggggagaccttg gaaattgggaactactctttctacgccttggacaaccagaacctaaggcagctatgggac tggggcaaacacaacctcaccatcactcaggggaaactcttcttccactataaccccaaa ctgtgcctgtcggaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag agaaatgacattgctctaaagaccaatggggaccaggcatcctgtgaaaatgaattactt aaattttcttacattcggacatcttatgacaagatcttgctgaaatgggagccgtattgg cctcctgacttccgagacctcctggggttcatgttgttctacaaagaggccccttaccag aatgtgacagaattcgatgggcaggatgcgtgtggctccaacagctggacagtggtggat attgacccgcctacgaggtccaacgaccccaagtcacagaaccatcctgggtggctgatg cgtggtctcaagccctggacccagtatgccatctttgtcaagaccctggtcaccttttct gatgaacgccgtacatacggagccaagagtgacatcatctatgtccagacagacgccact aatccttccgtccccctggatcccatctcagtttctaattcctcgtcccagattattctg aagtggaagcctccctccgaccccaacggcaatatcacacactacttggtgttctgggag aggcaggcggaagacagtgagctgtatgaactggattattgcctcaaagggttgaagctg ccctcccggacctggtctccaccgttcgagtcggaggggtcccagaagcacaaccagagt gagtatgaggagtctgctggcgaatgctgctcctgcccgaagaccgactctcagatcctc aaggagctggaggagtcctcgttcaggaaaacgtttgaagattacctgcacaacgtggtt ttcatccccagaaaatcatcttcaggccctgttgccgaggacgctaggccttcgaggaaa cgcagagcccttggtgacgtggggaatgtgacagcagccgtgcccactgttctggggttc cccaatagctcctccaccagcacacccacaagctcagaggagcacagacccttcgagaaa gtggtgaacaaggagtcgctggtcatctccggcctgcgtcactttactgggtatcgcatt gagcttcaggcttgcaaccaagattcccccgaggagaggtgtagcgtggctgcctatgtc agcgccaggaccatgcctgaagccaaggcagatgatattgtcggccccgtgacccatgaa atcttcgagaacaacgtcgttcacttgatgtggcaggagcccaaggaacccaacggtctg attgtgctgtatgaagtgagttaccgacgatatggcgaggaggagctgcacctctgcgtc tcccgccggcattatgctgtggagcgcggctgccggctgcgcgggctgctgcctgggaat tacagcgtgcgagttcgggctacctccctggcaggcaatgggtcttggacggaagccacc tacttctacgtgacagactatttagacgtgccatcaaatattgcaaagatcatcatcggt cccctcatctttgtctttctcttcagtgttgtgattggaagtatttgtctattcctgaga aagaggcagccagatgggccactgggaccattgtatgcttcttcaaacccagagtacctc agtgccagcgatgtgttcccatgctctgtgtatgtgccggacgagtgggaggtgcctcga gagaagatcacgctcctgcgagaactgggtcaaggctccttcggcatggtgtacgagggc aacgccagggacattgtcaagggtgaggcggagacccgcgtggcagtgaagacggtcaac gagtcggccagcctgcgagagcggatcgagtttctcaacgaggcttcggtcatgaagggc ttcacctgccaccatgtggtccgcctcctgggggtggtgtccaaaggccagccaacgctg gtggtgatggagttgatggctcacggagacctgaagagttacctccgttccctgcggcct gaggctgagaataaccccggccgccctccccctaccctgcaagaaatgattcagatggcg gcagagatcgccgatgggatggcatacctgaacgctaagaagttcgtgcaccgggatctt gcagcccggaactgcatggttgcccacgactttaccgtcaaaattggagacttcggaatg acaagagacatctatgaaacggattactaccggaaagggggcaaaggtctgctccccgtg cggtggatggcacctgaatccctcaaggacggagtcttcaccacctcttcagacatgtgg tctttcggtgtggtcctttgggaaattaccagcttggctgaacagccttaccaaggtcta tcaaatgagcaggtgctgaaatttgtcatggatggagggtacctggatcaacctgacaat tgtccagagagagtcaccgacctgatgcggatgtgctggcagttcaaccccaagatgcgt ccaaccttcctggagatcgtggacctgctcaaggatgacctgcaccccagctttcccgaa gtgtccttcttccacagcgaggagaacaaggcgcccgagagcgaggagctggaaatggag tttgaggacatggagagcgtgcccctggaccggtcctcgcacgcgcagagagaggaggcc ggggtccgggacggagggtcggcgctggggctaaagcgaaactatgacgagcacatcccc tatacccacatgaacgggggcaagaaaaacggacggattctgactttgccccggtcaaat ccttcctaa

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