Oryctolagus cuniculus (rabbit): 100009316
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Entry
100009316 CDS
T03373
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu01521
EGFR tyrosine kinase inhibitor resistance
ocu01522
Endocrine resistance
ocu04010
MAPK signaling pathway
ocu04012
ErbB signaling pathway
ocu04014
Ras signaling pathway
ocu04015
Rap1 signaling pathway
ocu04022
cGMP-PKG signaling pathway
ocu04024
cAMP signaling pathway
ocu04062
Chemokine signaling pathway
ocu04066
HIF-1 signaling pathway
ocu04068
FoxO signaling pathway
ocu04071
Sphingolipid signaling pathway
ocu04072
Phospholipase D signaling pathway
ocu04114
Oocyte meiosis
ocu04140
Autophagy - animal
ocu04148
Efferocytosis
ocu04150
mTOR signaling pathway
ocu04151
PI3K-Akt signaling pathway
ocu04210
Apoptosis
ocu04218
Cellular senescence
ocu04270
Vascular smooth muscle contraction
ocu04370
VEGF signaling pathway
ocu04371
Apelin signaling pathway
ocu04380
Osteoclast differentiation
ocu04510
Focal adhesion
ocu04540
Gap junction
ocu04550
Signaling pathways regulating pluripotency of stem cells
ocu04613
Neutrophil extracellular trap formation
ocu04620
Toll-like receptor signaling pathway
ocu04650
Natural killer cell mediated cytotoxicity
ocu04660
T cell receptor signaling pathway
ocu04662
B cell receptor signaling pathway
ocu04664
Fc epsilon RI signaling pathway
ocu04666
Fc gamma R-mediated phagocytosis
ocu04668
TNF signaling pathway
ocu04720
Long-term potentiation
ocu04722
Neurotrophin signaling pathway
ocu04725
Cholinergic synapse
ocu04726
Serotonergic synapse
ocu04730
Long-term depression
ocu04810
Regulation of actin cytoskeleton
ocu04910
Insulin signaling pathway
ocu04912
GnRH signaling pathway
ocu04914
Progesterone-mediated oocyte maturation
ocu04915
Estrogen signaling pathway
ocu04916
Melanogenesis
ocu04917
Prolactin signaling pathway
ocu04919
Thyroid hormone signaling pathway
ocu04921
Oxytocin signaling pathway
ocu04926
Relaxin signaling pathway
ocu04928
Parathyroid hormone synthesis, secretion and action
ocu04929
GnRH secretion
ocu04934
Cushing syndrome
ocu04935
Growth hormone synthesis, secretion and action
ocu05010
Alzheimer disease
ocu05022
Pathways of neurodegeneration - multiple diseases
ocu05034
Alcoholism
ocu05132
Salmonella infection
ocu05135
Yersinia infection
ocu05160
Hepatitis C
ocu05161
Hepatitis B
ocu05163
Human cytomegalovirus infection
ocu05164
Influenza A
ocu05165
Human papillomavirus infection
ocu05166
Human T-cell leukemia virus 1 infection
ocu05167
Kaposi sarcoma-associated herpesvirus infection
ocu05170
Human immunodeficiency virus 1 infection
ocu05200
Pathways in cancer
ocu05205
Proteoglycans in cancer
ocu05206
MicroRNAs in cancer
ocu05207
Chemical carcinogenesis - receptor activation
ocu05208
Chemical carcinogenesis - reactive oxygen species
ocu05210
Colorectal cancer
ocu05211
Renal cell carcinoma
ocu05212
Pancreatic cancer
ocu05213
Endometrial cancer
ocu05214
Glioma
ocu05215
Prostate cancer
ocu05216
Thyroid cancer
ocu05218
Melanoma
ocu05219
Bladder cancer
ocu05220
Chronic myeloid leukemia
ocu05221
Acute myeloid leukemia
ocu05223
Non-small cell lung cancer
ocu05224
Breast cancer
ocu05225
Hepatocellular carcinoma
ocu05226
Gastric cancer
ocu05230
Central carbon metabolism in cancer
ocu05231
Choline metabolism in cancer
ocu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100009316 (MAP2K1)
04012 ErbB signaling pathway
100009316 (MAP2K1)
04014 Ras signaling pathway
100009316 (MAP2K1)
04015 Rap1 signaling pathway
100009316 (MAP2K1)
04370 VEGF signaling pathway
100009316 (MAP2K1)
04371 Apelin signaling pathway
100009316 (MAP2K1)
04668 TNF signaling pathway
100009316 (MAP2K1)
04066 HIF-1 signaling pathway
100009316 (MAP2K1)
04068 FoxO signaling pathway
100009316 (MAP2K1)
04072 Phospholipase D signaling pathway
100009316 (MAP2K1)
04071 Sphingolipid signaling pathway
100009316 (MAP2K1)
04024 cAMP signaling pathway
100009316 (MAP2K1)
04022 cGMP-PKG signaling pathway
100009316 (MAP2K1)
04151 PI3K-Akt signaling pathway
100009316 (MAP2K1)
04150 mTOR signaling pathway
100009316 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100009316 (MAP2K1)
04148 Efferocytosis
100009316 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
100009316 (MAP2K1)
04210 Apoptosis
100009316 (MAP2K1)
04218 Cellular senescence
100009316 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100009316 (MAP2K1)
04540 Gap junction
100009316 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
100009316 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100009316 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100009316 (MAP2K1)
04620 Toll-like receptor signaling pathway
100009316 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
100009316 (MAP2K1)
04660 T cell receptor signaling pathway
100009316 (MAP2K1)
04662 B cell receptor signaling pathway
100009316 (MAP2K1)
04664 Fc epsilon RI signaling pathway
100009316 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
100009316 (MAP2K1)
04062 Chemokine signaling pathway
100009316 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
100009316 (MAP2K1)
04929 GnRH secretion
100009316 (MAP2K1)
04912 GnRH signaling pathway
100009316 (MAP2K1)
04915 Estrogen signaling pathway
100009316 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
100009316 (MAP2K1)
04917 Prolactin signaling pathway
100009316 (MAP2K1)
04921 Oxytocin signaling pathway
100009316 (MAP2K1)
04926 Relaxin signaling pathway
100009316 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
100009316 (MAP2K1)
04919 Thyroid hormone signaling pathway
100009316 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
100009316 (MAP2K1)
04916 Melanogenesis
100009316 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100009316 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
100009316 (MAP2K1)
04726 Serotonergic synapse
100009316 (MAP2K1)
04720 Long-term potentiation
100009316 (MAP2K1)
04730 Long-term depression
100009316 (MAP2K1)
04722 Neurotrophin signaling pathway
100009316 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
100009316 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100009316 (MAP2K1)
05206 MicroRNAs in cancer
100009316 (MAP2K1)
05205 Proteoglycans in cancer
100009316 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
100009316 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
100009316 (MAP2K1)
05230 Central carbon metabolism in cancer
100009316 (MAP2K1)
05231 Choline metabolism in cancer
100009316 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100009316 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
100009316 (MAP2K1)
05212 Pancreatic cancer
100009316 (MAP2K1)
05225 Hepatocellular carcinoma
100009316 (MAP2K1)
05226 Gastric cancer
100009316 (MAP2K1)
05214 Glioma
100009316 (MAP2K1)
05216 Thyroid cancer
100009316 (MAP2K1)
05221 Acute myeloid leukemia
100009316 (MAP2K1)
05220 Chronic myeloid leukemia
100009316 (MAP2K1)
05218 Melanoma
100009316 (MAP2K1)
05211 Renal cell carcinoma
100009316 (MAP2K1)
05219 Bladder cancer
100009316 (MAP2K1)
05215 Prostate cancer
100009316 (MAP2K1)
05213 Endometrial cancer
100009316 (MAP2K1)
05224 Breast cancer
100009316 (MAP2K1)
05223 Non-small cell lung cancer
100009316 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100009316 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
100009316 (MAP2K1)
05161 Hepatitis B
100009316 (MAP2K1)
05160 Hepatitis C
100009316 (MAP2K1)
05164 Influenza A
100009316 (MAP2K1)
05163 Human cytomegalovirus infection
100009316 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
100009316 (MAP2K1)
05165 Human papillomavirus infection
100009316 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
100009316 (MAP2K1)
05135 Yersinia infection
100009316 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100009316 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
100009316 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
100009316 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100009316 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100009316 (MAP2K1)
01522 Endocrine resistance
100009316 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ocu01001
]
100009316 (MAP2K1)
Enzymes [BR:
ocu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
100009316 (MAP2K1)
Protein kinases [BR:
ocu01001
]
Serine/threonine kinases: STE group
STE7 family
100009316 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
100009316
NCBI-ProteinID:
NP_001076098
Ensembl:
ENSOCUG00000008782
UniProt:
P29678
Structure
PDB
LinkDB
All DBs
Position
17:complement(6903041..6929866)
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgccaaagaagaagcccacccccatccagctgaatcctgcccctgacggctcggcggtg
aatggtaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgacgagcagcagcggaagcgcctggaggccttcctcacccagaagcagaaagtg
ggagagctgaaggacgatgacttcgagaagatcagtgagctgggagccggcaacggcggc
gtggtgttcaaggtctcccacaagcccagtggcctggtgatggccagaaagcttattcac
ctggagatcaaacctgctatccggaaccagatcataagggagctgcaggttctgcacgag
tgcaactccccgtacatcgtgggcttctacggggcattctacagcgatggcgagatcagc
atctgcatggagcacatggacgggggttccttggatcaagtcctgaagaaagctggacgg
attcccgagcaaattttggggaaagttagcattgctgtgatcaagggcctgacgtatctg
agggagaagcacaagatcatgcacagagatgtgaagccctccaacatcctggtcaactcc
cgcggggagatcaagctctgtgacttcggggtcagtgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcttatatgtcgcccgagagactccaggggacacactac
tctgtgcagtcggacatctggagcatggggctgtccctggtggagatggcggtggggcgg
taccccatcccgccccccgacgccaaggagctggagctgatgtttgggtgccaggtggag
ggcgatgcggccgagactccgcccaggcccaggacccctgggcggcccctcagctcgtat
ggaatggatagccggcctcccatggcgatttttgagctgctggattacatcgtcaatgag
cctcctccgaaactccccagcgcagtcttcagcctggagtttcaagattttgtgaataaa
tgcttaataaaaaaccccgccgagagagcagacttgaagcagctcatggttcatgctttt
atcaagaggtctgatgccgaggaggtggattttgctggttggctgtgctccaccatcggc
cttaaccagcccagcacgccgacgcacgcggccggtgtgtga
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